CD8+CD25+ T cells reduce atherosclerosis in apoE(−/−) mice

Zhou, Jianchang; Dimayuga, Paul C.; Zhao, Xiaoning; Yano, Juliana; Lio, Wai Man; Trinidad, Portia; Honjo, Tomoyuki; Cercek, Bojan; Shah, Prediman K.; Chyu, Kuang‐Yuh

doi:10.1016/j.bbrc.2013.12.057

Cited by 34 publications

(21 citation statements)

References 24 publications

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“…Serum was collected for cholesterol measurement using a commercially available kit. Aortas from the arch to the iliac branch were cleaned and processed for en face lipid staining with oil red‐o as previously described . Atherosclerotic area was measured using computer‐assisted morphometry (ImagePro, Media Cybernetics).…”

Section: Methodsmentioning

confidence: 99%

“…These studies used various immunization techniques with the intent of inducing CD4+ T‐cell responses and antibody production. Recent reports suggest that CD8+ T cells are also important modulators of atherosclerosis . We have reported that the athero‐protective immune response to an experimental apoB‐100 peptide vaccine in apoE −/− mice, called p210, is mediated by CD8+ T cells .…”

Section: Introductionmentioning

confidence: 98%

“…T cells are found in atherosclerotic plaques of both experimental animals and humans . Evidence suggests that different T‐cell types exist with varied functions . In addition, there is evidence to support local antigen presentation and activation inside the plaque .…”

Section: Introductionmentioning

confidence: 99%

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Identification of apoB‐100 Peptide‐Specific CD8+ T Cells in Atherosclerosis

Dimayuga

Zhao

Yano

et al. 2017

JAHA

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BackgroundT cells are found in atherosclerotic plaques, with evidence supporting a potential role for CD8+ T cells in atherogenesis. Prior studies provide evidence of low‐density lipoprotein and apoB‐100 reactive T cells, yet specific epitopes relevant to the disease remain to be defined. The current study was undertaken to identify and characterize endogenous, antigen‐specific CD8+ T cells in atherosclerosis.Methods and ResultsA peptide fragment of apoB‐100 that tested positive for binding to the mouse MHC‐I allele H2Kb was used to generate a fluorescent‐labeled H2Kb pentamer and tested in apoE−/− mice. H2Kb pentamer(+)CD8+ T cells were higher in apoE−/− mice fed an atherogenic diet compared with those fed a normal chow. H2Kb pentamer (+)CD8+ T cells in atherogenic diet–fed mice had significantly increased effector memory phenotype with a shift in Vβ profile. H2Kb pentamer blocked lytic activity of CD8+ T cells from atherogenic diet–fed mice. Immunization of age‐matched apoE−/− mice with the apoB‐100 peptide altered the immune‐dominant epitope of CD8+ T cells and reduced atherosclerosis.ConclusionsOur study provides evidence of a self‐reactive, antigen‐specific CD8+ T‐cell population in apoE−/− mice. Immune modulation using the peptide antigen reduced atherosclerosis in apoE−/− mice.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Identification of apoB‐100 Peptide‐Specific CD8+ T Cells in Atherosclerosis

Dimayuga

Zhao

Yano

et al. 2017

JAHA

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“…Th2 and Th17 cell populations are also found but their functions are still unclear . The functions of Treg cells in atherosclerosis have been largely investigated and show an overall atheroprotective role . It is also important to consider the possible atherogenic effect of T cell populations led by their potential ability to regulate cholesterol levels through the lymphatic system .…”

Section: T Cells In Atherosclerosismentioning

confidence: 99%

Follicular regulatory T cell in atherosclerosis

Baptista

Mach

Brandt

2018

Journal of Leukocyte Biology

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Atherosclerosis is a chronic inflammatory disease involving the infiltration of immune cells, such as monocytes/macrophages, neutrophils, T cells, and B cells, into the inner layer of vessel walls. T and B cell functions in the process of atherogenesis, as well as their mutual regulation, have been investigated but several aspects remain to be clarified. In the present review, we give a brief overview of the functions of follicular regulatory T cell (Tfr) on follicular T (Tfh) and B cell regulation related to atherosclerosis pathogenesis, including their influence on lymphangiogenesis and lipoprotein metabolism. We will also discuss their potential therapeutics properties in the resolution of established atherosclerotic lesions.

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“…CD8 cells are much less studied in the context of atherosclerosis, but recent studies suggest that they may be proatherogenic 39 , although one very recent study found that a CD8+CD25+ subset of CD8 cells may be atheroprotective 40 . Expect to see more studies emerging on CD8 cells in atherosclerosis in the next few years as interest in this topic is expanding.…”

Section: Introductionmentioning

confidence: 99%

Lymphocytes in Atherosclerosis

Hedrick

2015

ATVB

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CD8+CD25+ T cells reduce atherosclerosis in apoE(−/−) mice

Cited by 34 publications

References 24 publications

Identification of apoB‐100 Peptide‐Specific CD8+ T Cells in Atherosclerosis

Identification of apoB‐100 Peptide‐Specific CD8+ T Cells in Atherosclerosis

Follicular regulatory T cell in atherosclerosis

Lymphocytes in Atherosclerosis

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