CD56+ T cells inhibit hepatitis C virus replication in human hepatocytes

Li, Ye; Wang, Xu; Wang, Shihong; Wang, Yan‐Jian; Song, Li; Hou, Wei; Zhou, Lin; Li, He; Ho, Wen‐Zhe

doi:10.1002/hep.22715

Cited by 47 publications

(60 citation statements)

References 41 publications

(55 reference statements)

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“…Although it is well established that reduced CD8 + CTLs and increased FOXP3 + cells in HCC are coupled with poor prognosis (18,19), it is now also being recognized that the innate arm of the immune system may also perform a potentially important role in immune responses in liver diseases (25,(28)(29)(30)(31)(32). Suppressive innate immunocytes including regulatory DCs, γδ T cells and NKT cells have gained attention in previous years (15,(20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

A different representation of natural T cells and natural killer cells between tumor-infiltrating and periphery lymphocytes in human hepatocellular carcinoma

Dong

Song

et al. 2017

Oncology Letters

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Section: Discussionmentioning

confidence: 99%

A different representation of natural T cells and natural killer cells between tumor-infiltrating and periphery lymphocytes in human hepatocellular carcinoma

Dong

Song

et al. 2017

Oncology Letters

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“…Thus, the association between infectious pathogens and CD56 upregulation is of particular interest. CD56 + T cells were reported to play important roles in preventing viral replication through IFN-γ production4445. The upregulation of CD56 on T cells was observed even in healthy cytomegalovirus-positive subjects46.…”

Section: Discussionmentioning

confidence: 99%

Altered T cell phenotypes associated with clinical relapse of multiple sclerosis patients receiving fingolimod therapy

Fujii

Kondo

Ochi

et al. 2016

Sci Rep

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Multiple sclerosis (MS) is a T cell-mediated autoimmune disease. Fingolimod, a highly effective disease-modifying drug for MS, retains CCR7+ central memory T cells in which autoaggressive T cells putatively exist, in secondary lymphoid organs, although relapse may still occur in some patients. Here, we analyzed the T cell phenotypes of fingolimod-treated, fingolimod-untreated patients, and healthy subjects. The frequency of CD56+ T cells and granzyme B-, perforin-, and Fas ligand-positive T cells significantly increased during fingolimod treatment. Each T cell subpopulation further increased during relapse. Interestingly, T cells from fingolimod-treated patients exhibited interferon-γ biased production, and more myelin basic protein-reactive cells was noted in CD56+ than in CD56− T cells. It is likely that the altered T cell phenotypes play a role in MS relapse in fingolimod-treated patients. Further clinical studies are necessary to investigate whether altered T cell phenotypes are a biomarker for relapse under fingolimod therapy.

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“…Invariant NKTs were protective in viral hepatitis by secreting IFN-γ to inhibit the proliferation of hepatitis B and C virus in liver cells (Sprengers et al 2008; Ye et al 2009). This protective function of iNKT cells is induced by the stimulation of CD1d-presented host lysophospholipids (Zeissig et al 2012).…”

Section: Nkt Cells In Vivomentioning

confidence: 99%

Donor-unrestricted T cells in the human CD1 system

Huang

Moody

2016

Immunogenetics

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The CD1 and MHC systems are specialized for lipid and peptide display, respectively. Here, we review evidence showing how cellular CD1a, CD1b, CD1c, and CD1d proteins capture and display many cellular lipids to T cell receptors (TCRs). Increasing evidence shows that CD1-reactive T cells operate outside two classical immunogenetic concepts derived from the MHC paradigm. First, because CD1 proteins are non-polymorphic in human populations, T cell responses are not restricted to the donor’s genetic background. Second, the simplified population genetics of CD1 antigen-presenting molecules can lead to simplified patterns of TCR usage. As contrasted with donor-restricted patterns of MHC-TCR interaction, the donor-unrestricted nature of CD1-TCR interactions raises the prospect that lipid agonists and antagonists of T cells could be developed.

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CD56+ T cells inhibit hepatitis C virus replication in human hepatocytes

Cited by 47 publications

References 41 publications

A different representation of natural T cells and natural killer cells between tumor-infiltrating and periphery lymphocytes in human hepatocellular carcinoma

A different representation of natural T cells and natural killer cells between tumor-infiltrating and periphery lymphocytes in human hepatocellular carcinoma

Altered T cell phenotypes associated with clinical relapse of multiple sclerosis patients receiving fingolimod therapy

Donor-unrestricted T cells in the human CD1 system

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