Katrina Collins, Jolene L. Cardinali, Laila O. Mnayer, Joseph A. DiGiuseppe
Abstract:Background: CD49f (integrin α6) is a useful marker for minimal residual disease (MRD) detection in B lymphoblastic leukemia and has recently been suggested to mediate infiltration of the central nervous system by leukemic B lymphoblasts. However, data regarding expression of CD49f protein in B lymphoblastic leukemia are limited, and whether CD49f protein expression varies among genetic subgroups of B lymphoblastic leukemia is unknown. Methods: CD49f protein expression was characterized by flow cytometry in a s…
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