CD47 on artificial structures

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

“…For instance, CD47 is an integrin-associated protein, known as an universal molecular "market of self," involved in the inhibition of phagocytosis, antiinflammation processes, apoptosis, proliferation, adhesion, and migration. [158] This transmembrane protein binds to signal regulatory protein alpha expressed by macrophages and myeloid cells, activating a sign known as "do not eat me" and suppressing the phagocytic processes. [159] As a consequence, surface modification of PLGA nanoparticles with CD47 market, considered as a "stealth or inert artificial structure," is indeed one of the most promising strategies to escape phagocyte uptake and consequently, early PLGA-based DDSs clearance.…”

Antigen-specific T cell Redirectors: a nanoparticle based approach for redirecting T cells

“…Furthermore, antibodies and antibody like complexes have an extremely short in vivo half-life [ 18 – 20 ], whereas 10-200nm particles demonstrate prolonged blood circulation times [ 21 – 24 ]. Additionally, particles can be co-functionalized with molecules such as CD47 to further enhance in vivo performance [ 25 – 27 ]. Moreover, antibodies are known to diffuse rapidly into the surrounding tissue impacting the overall efficacy [ 28 ], however nanoparticles have been described more stably associated with targeted tissues [ 29 ].…”