“…For instance, CD47 is an integrin-associated protein, known as an universal molecular "market of self," involved in the inhibition of phagocytosis, antiinflammation processes, apoptosis, proliferation, adhesion, and migration. [158] This transmembrane protein binds to signal regulatory protein alpha expressed by macrophages and myeloid cells, activating a sign known as "do not eat me" and suppressing the phagocytic processes. [159] As a consequence, surface modification of PLGA nanoparticles with CD47 market, considered as a "stealth or inert artificial structure," is indeed one of the most promising strategies to escape phagocyte uptake and consequently, early PLGA-based DDSs clearance.…”