volume 9, issue 4, Pe93692 2014
DOI: 10.1371/journal.pone.0093692
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Ying-Erh Chou, Ming-Ju Hsieh, Chung-Han Hsin, Whei-Ling Chiang, Yi-Cheng Lai, Yu-Hsien Lee, Shu-Ching Huang, Shun-Fa Yang, Chiao-Wen Lin

Abstract: BackgroundOral squamous cell carcinoma (OSCC) is the fourth leading cause of male cancer death in Taiwan. Exposure to environmental carcinogens is the primary risk factor for developing OSCC. CD44, a well-known tumor marker, plays a crucial role in tumor cell differentiation, invasion, and metastasis. This study investigated CD44 single-nucleotide polymorphisms (SNPs) with environmental risk factors to determine OSCC susceptibility and clinicopathological characteristics.Methodology/Principal FindingsReal-time…

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