2006
DOI: 10.1111/j.0303-6987.2006.00463.x
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CD44 and hyaluronate expression in follicular mucinosis

Abstract: Our results suggest an active secretion of HA by follicular cells in follicular mucinosis.

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Cited by 12 publications
(4 citation statements)
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“…This finding suggests that abnormalities in CD44 expression are not the origin of or associated with cutaneous mucinosis of shar‐pei dogs and that reduced catabolism of HA due to decreased cell surface receptors seems unlikely. This finding agrees with recent publications on human cutaneous mucinosis, in which the authors could not find a decreased expression of CD44 15,16 …”
Section: Discussionsupporting
confidence: 93%
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“…This finding suggests that abnormalities in CD44 expression are not the origin of or associated with cutaneous mucinosis of shar‐pei dogs and that reduced catabolism of HA due to decreased cell surface receptors seems unlikely. This finding agrees with recent publications on human cutaneous mucinosis, in which the authors could not find a decreased expression of CD44 15,16 …”
Section: Discussionsupporting
confidence: 93%
“…Studies in transgenic mice and in several human diseases including lichen sclerosus and atrophicus, and myxoid dermatofibroma, have inversely correlated the expression of CD44 in cells and the accumulation of HA: a low expression of CD44 in epithelial cells is associated with depositions of HA in the surrounding dermis 12–14 . On the other hand, in other cutaneous diseases such as follicular mucinosis, this correlation could not be established 15,16 …”
Section: Introductionmentioning
confidence: 99%
“…In any case, it remains far from clear why a dermal‐type mucin is deposited selectively within an epithelial structure and, second, why the mucin might have been sulfated. In FM, mucin is produced by secretory function of follicular cells, 8 possibly stimulated by cytokines released from perifollicular T lymphocytes 9 . This point is also supported by ultrastructural studies of acantholytic keratinocytes displaying a hypertrophic Golgi apparatus with vesicles and a large vacuole with filamentous material inside 10 .…”
Section: Discussionmentioning
confidence: 73%
“…4,30 On the other hand, the concurrence of dermal interstitial mucin in up to 7 cases (54%) is intriguing. There was a periappendageal inflammatory infiltrate in all cases, which seemed to be a necessary condition independently of the underlying disorder.…”
Section: Discussionmentioning
confidence: 99%