CD40 Ligand Is Increased in Mast Cells in Psoriasis and Actinic Keratosis but Less So in Epithelial Skin Carcinomas

Haimakainen, Salla; Kaukinen, Antti; Suttle, Mireille-Maria; Pelkonen, Jukka; Harvima, Ilkka T.

doi:10.1080/07357907.2017.1289216

Cited by 6 publications

(14 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In line with this finding, about 60 % of patients with HS report moderate or severe pruritus (Matusiak et al, 2018). Similarly, more than one third of patients with basal cell carcinoma or squamous cell carcinoma report to have pruritus (Mills et al, 2012; Yosipovitch et al, 2014) and elevated mast cell numbers in both tumors have been reported (Diaconu et al, 2007; Haimakainen et al, 2017). The connection between mast cell numbers and itch is not so clear in melanoma, in which less patients report itch (Yosipovitch et al, 2014) and both increased (Toth-Jakatics et al, 2000; Ribatti et al, 2003a, b), and decreased (Biswas et al, 2014; Siiskonen et al, 2015; Rajabi et al, 2017) mast cell numbers have been reported.…”

Section: Mast Cells Skin Diseases and Itchmentioning

confidence: 99%

Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation

Siiskonen

Harvima

2019

Front. Cell. Neurosci.

122

View full text Add to dashboard Cite

The intimate interaction between mast cells and sensory nerves can be illustrated by the wheal and surrounding flare in an urticarial reaction in human skin. This reaction is typically associated with an intense itch at the reaction site. Upon activation, cutaneous mast cells release powerful mediators, such as histamine, tryptase, cytokines, and growth factors that can directly stimulate corresponding receptors on itch-mediating sensory nerves. These include, e.g., H1-and H4-receptors, proteaseactivated receptor-2, IL-31 receptor, and the high-affinity receptor of nerve growth factor (TrkA). On the other hand, sensory nerves can release neuropeptides, including substance P and vasoactive intestinal peptide, that are able to stimulate mast cells to release mediators leading to potentiation of the reciprocal interaction, inflammation, and itch. Even though mast cells are well recognized for their role in allergic skin whealing and urticaria, increasing evidence supports the reciprocal function between mast cells and sensory nerves in neurogenic inflammation in chronic skin diseases, such as psoriasis and atopic dermatitis, which are often characterized by distressing itch, and exacerbated by psychological stress. Increased morphological contacts between mast cells and sensory nerves in the lesional skin in psoriasis and atopic dermatitis as well as experimental models in mice and rats support the essential role for mast cellsensory nerve communication in consequent pruritus. Therefore, we summarize here the present literature pointing to a close association between mast cells and sensory nerves in pruritic skin diseases as well as review the essential supporting findings on pruritic models in mice and rats.

show abstract

Section: Mast Cells Skin Diseases and Itchmentioning

confidence: 99%

Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation

Siiskonen

Harvima

2019

Front. Cell. Neurosci.

122

View full text Add to dashboard Cite

show abstract

“…Their data demonstrated that CD40-CD40L cross-talk integrated strong antigenic signals and microbial stimuli to induce the development of IL-17-producing CD4 + T cells ( Iezzi et al, 2009 ). In psoriatic skin lesions, the number of CD40 + cells (keratinocytes, Langerhans cells, mature DCs) and CD40L + mast cells is higher than that in healthy skin ( Haimakainen et al, 2017 ). In patients with psoriatic arthritis (PsA), the expression of CD40 was increased in synovial fluid B cells (Armas-Gonzalez et al, 2015 ) and the expression of CD40L was significantly upregulated on activated T cells compared to healthy controls ( Daoussis et al, 2007 ).…”

Section: Co-stimulatory Moleculesmentioning

confidence: 99%

The Role of Co-Signaling Molecules in Psoriasis and Their Implications for Targeted Treatment

Liu

Xu²,

Wu³

2021

Front. Pharmacol.

View full text Add to dashboard Cite

Psoriasis is a chronic, systemic immune-mediated inflammatory disease manifesting in the skin, joint or both. Co-signaling molecules are essential for determining the magnitude of the T cell response to the antigen. According to the function of co-signaling molecules, they can be divided into co-stimulatory molecules and co-inhibitory molecules. The role of co-signaling molecules in psoriasis is recognized, mainly including the co-stimulatory molecules CD28, CD40, OX40, CD27, DR3, LFA-1, and LFA-3 and the co-inhibitory molecules CTLA-4, PD-1, and TIM-3. They impact the pathological process of psoriasis by modulating the immune strength of T cells, regulating the production of cytokines or the differentiation of Tregs. In recent years, immunotherapies targeting co-signaling molecules have made significant progress and shown broad application prospects in psoriasis. This review aims to outline the possible role of co-signaling molecules in the pathogenesis of psoriasis and their potential application for the treatment of psoriasis.

show abstract

“…Recently, mast cells were reported to express vitamin D3 metabolising enzymes, CYP27A1 and CYP27B1, in skin SCC and BCC, suggesting a role in an immunosuppressive environment in skin cancers . In addition, the percentage of CD40 ligand‐positive MCs was found lower in lesional BCC and SCC compared to actinic keratosis and psoriasis, indicating a dysregulated immune response by mast cell CD40L in skin cancer …”

Section: The Role Of Mast Cells In Uv‐driven Diseasesmentioning

confidence: 99%

Ultraviolet radiation and skin mast cells: Effects, mechanisms and relevance for skin diseases

Siiskonen

Smorodchenko

Krause

et al. 2017

Experimental Dermatology

View full text Add to dashboard Cite

Mast cells (MCs) are well known as versatile effector cells in allergic reactions and several other immune responses. Skin MCs and cutaneous MC responses are subject to the effects of environmental factors including ultraviolet radiation (UVR). Numerous studies have assessed the effects of UVR on MCs, in vitro and in vivo. Interestingly, UVR seems to have variable effects on non-activated and activated mast cells. In general, UV therapy is beneficial in the treatment of urticaria and mastocytosis, but the effects are variable depending on treatment regimen and type of UVR. Here, we review and summarise key reports from the older and current literature on the crosstalk of UVR and skin MCs. Specifically, we present the literature and discuss published reports on the effects of UVR on skin MCs in rodents and humans. In addition, we review the role of MCs in UVR-driven skin diseases and the influence of UV light on MC-mediated skin diseases. This summary of our current understanding of the interplay of skin MCs and UVR may help to improve the management of patients with urticaria and other MC disorders, to identify current gaps of knowledge, and to guide further research. K E Y W O R D Scancer, mast cell, ultraviolet radiation, urticaria

show abstract

CD40 Ligand Is Increased in Mast Cells in Psoriasis and Actinic Keratosis but Less So in Epithelial Skin Carcinomas

Cited by 6 publications

References 20 publications

Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation

Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation

The Role of Co-Signaling Molecules in Psoriasis and Their Implications for Targeted Treatment

Ultraviolet radiation and skin mast cells: Effects, mechanisms and relevance for skin diseases

Contact Info

Product

Resources

About