volume 81, issue 18, P9801-9811 2007
DOI: 10.1128/jvi.00941-07
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Abstract: Recent studies have established a protective role for T cells during primary West Nile virus (WNV) infection. Binding of CD40 by CD40 ligand (CD40L) on activated CD4؉ T cells provides an important costimulatory signal for immunoglobulin class switching, antibody affinity maturation, and priming of CD8 ؉ T-cell responses. We examined here the function of CD40-dependent interactions in limiting primary WNV infection. Compared to congenic wild-type mice, CD40؊/؊ mice uniformly succumbed to WNV infection. Althoug…

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