CD34 staining pattern distinguishes basal cell carcinoma from trichoepithelioma

Kirchmann, Tin Tin T.

doi:10.1001/archderm.130.5.589

Cited by 72 publications

(76 citation statements)

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“…These differences are widely independent of the anatomical site and histological type of carcinoma and consist of a loss of CD34 + fibrocytes and a subsequent gain of a-smooth muscle antigen (SMA)-positive myofibroblasts [2,3,4,6,12,17]. CD34 + fibrocytes appear to be constitutive elements of the connective tissue in a multitude of anatomical sites, such as the skin [12], the breast [3,6], the gastrointestinal tract [2,14,15], and the cervix [4]. In all of the aforementioned locations, the stroma of invasive carcinomas discloses a reduction or complete loss of CD34 + fibrocytes paralleled by the occurrence of a-SMApositive myofibroblasts [2,3,4,6,12,17].…”

Section: Introductionmentioning

confidence: 99%

“…CD34 + fibrocytes appear to be constitutive elements of the connective tissue in a multitude of anatomical sites, such as the skin [12], the breast [3,6], the gastrointestinal tract [2,14,15], and the cervix [4]. In all of the aforementioned locations, the stroma of invasive carcinomas discloses a reduction or complete loss of CD34 + fibrocytes paralleled by the occurrence of a-SMApositive myofibroblasts [2,3,4,6,12,17]. In addition to their function as matrix-producing [5,8] and antigenpresenting cells [7], CD34 + fibrocytes secrete plateletderived growth factor (PDGF) [10], the receptor of which, c-kit (CD117), a protein receptor with tyrosine kinase activity, is structurally identical to that of stem cell factor (SCF).…”

Section: Introductionmentioning

confidence: 99%

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CD34 + fibrocytes, a-smooth muscle antigen-positive myofibroblasts, and CD117 expression in the stroma of invasive squamous cell carcinomas of the oral cavity, pharynx, and larynx

et al. 2004

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We investigated tumor-free mucosa and squamous cell carcinomas of the oral cavity, the pharynx, and larynx with respect to the presence of stromal CD34+ fibrocytes and alpha-smooth muscle antigen (SMA)-positive myofibroblasts. Additionally, stromal expression of CD117 was analyzed. A total of 39 squamous cell carcinomas were assessed immunohistochemically. In all cases investigated, CD34+ fibrocytes were found in the tumor-free stroma, whereas alpha-SMA-positive myofibroblasts were lacking. Areas of lymphocytic infiltration disclosed a focal reduction of CD34+ fibrocytes. CD117 expression was absent from the tumor-free stroma. Of 39 squamous cell carcinomas, 33 were free of stromal CD34+ fibrocytes, and, in 31 carcinomas, stromal alpha-SMA-positive myofibroblasts occurred at least focally. CD117-positive stromal spindle cells were found in 25 carcinomas. Compared with tumor-free mucosa, the number of tissue mast cells was significantly increased in carcinomas. We conclude that stromal remodeling induced by invasive carcinomas is characterized by a loss of CD34+ fibrocytes and subsequent gain of alpha-SMA-positive myofibroblasts. The diagnostic impact of this finding is, however, limited by the fact that chronic inflammation may also be accompanied by a focal loss of CD34+ fibrocytes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CD34 + fibrocytes, a-smooth muscle antigen-positive myofibroblasts, and CD117 expression in the stroma of invasive squamous cell carcinomas of the oral cavity, pharynx, and larynx

et al. 2004

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“…They are believed to play a supportive role in the maturation and proliferation of adjacent cells. These cells have been studied only in the field of dermatopathology [2,3,8,11] and in the stroma of a few tumors such as major salivary gland pleomorphic adenoma [6] and gastric adenocarcinoma [9,12]. However, their distribution and role in organized lymphoid tissue such as that in palatine tonsils has not been studied to date.…”

Section: Introductionmentioning

confidence: 99%

S-100 protein-positive dendritic cells and CD34-positive dendritic interstitial cells in palatine tonsils

Papadas

Batistatou²,

Ravazoula

et al. 2001

European Archives of Oto-Rhino-Laryngology

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Dendritic cells (DCs) are effective antigen-presenting cells and have been shown to mature from precursor CD34-positive stromal cells (dendritic interstitial cells, DICs) or monocytes. To gain insight into the local immune response in human tonsils, we investigated immunohistochemically the presence of DCs and DICs in 17 non-hyperplastic and 13 hyperplastic tonsils. Dense infiltrates of S-100-positive DCs were noted in the majority of hyperplastic tonsils, while there were fewer in non-hyperplastic tonsils. DICs were noted specifically at the periphery in the dense hemi-capsule cap that separates the tonsil from the underlying muscle. In addition, their small number suggests that the accumulation of S-100 dendritic cells in hyperplastic palatine tonsils is achieved through migration from other sites rather than through maturation from precursors locally.

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“…Introduction CD34 + fibrocytes have been detected in normal skin [16], normal breast tissue [4,20,24], and in various cutaneous [5,6,9,10,23] and mesenchymal tumors [13,17,19,20,21,22]. To date, the origin of this cell population remains enigmatic, but experimental studies support the assumption that CD34 + fibrocytes derive from myeloid precursors [2].…”

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confidence: 99%

CD34+ fibrocytes in neoplastic and inflammatory pancreatic lesions

et al. 2001

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Besides its function as a matrix-producing cell, the CD34+ fibrocyte has been reported to be an antigen-presenting cell capable of priming naive T cells in situ. Therefore, it has been claimed that the CD34+ fibrocyte may play an important role in host response to tissue damage. The objective of the present study was to analyze the presence and distribution of CD34+ fibrocytes and smooth muscle actin (SMA) reactive myofibroblasts in relation to the underlying pancreatic disease. We investigated a total of 12 pancreatic adenocarcinomas, 7 endocrine tumors of the pancreas, and 8 cases of chronic pancreatitis; in 11 cases, normal pancreatic tissue was available. The stroma of normal pancreatic tissue harbored diffusely scattered CD34+ fibrocytes. Chronic pancreatitis was characterized by an increased number of stromal CD34+ fibrocytes paralleled by a gain of SMA reactive myofibroblasts which were not observed in the normal pancreatic stroma. The stroma of pancreatic ductal adenocarcinomas and endocrine tumors was devoid of CD34+ fibrocytes or showed at least a focal loss of this cell type, whereas SMA reactive myofibroblasts were detected in both endocrine tumors and adenocarcinomas. We conclude that detection of CD34+ fibrocytes may constitute an adjunctive tool in distinguishing chronic pancreatitis from ductal adenocarcinoma since the absence of this cell population strongly favors a neoplastic process. Moreover, CD34+ fibrocytes and myofibroblasts appear to be involved in stromal remodeling associated with chronic pancreatitis and ductal adenocarcinoma.

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CD34 staining pattern distinguishes basal cell carcinoma from trichoepithelioma

Cited by 72 publications

References 0 publications

CD34 + fibrocytes, a-smooth muscle antigen-positive myofibroblasts, and CD117 expression in the stroma of invasive squamous cell carcinomas of the oral cavity, pharynx, and larynx

CD34 + fibrocytes, a-smooth muscle antigen-positive myofibroblasts, and CD117 expression in the stroma of invasive squamous cell carcinomas of the oral cavity, pharynx, and larynx

S-100 protein-positive dendritic cells and CD34-positive dendritic interstitial cells in palatine tonsils

CD34+ fibrocytes in neoplastic and inflammatory pancreatic lesions

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