CD30L+ classical monocytes play a pro-inflammatory role in the development of ulcerative colitis in patients

Mei, Chenxue; Xiao, Wang; Meng, Fanxiang; Zhang, Xiaoqing; Gan, Lu; Wang, Yuanyuan; Sun, Xun

doi:10.1016/j.molimm.2021.06.016

Cited by 8 publications

(4 citation statements)

References 54 publications

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“…CD30L levels in classical monocytes in the peripheral circulation of patients were significantly elevated and correlated positively with the severity of UC. CD30L may be involved in monocyte-mediated inflammation in patients with UC through the activation of circulating classical monocytes [ 24 ]. High monocyte counts were significantly and negatively correlated with clinical remission, mucosal healing, and complete mucosal healing [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated single-cell and bulk RNA sequencing reveals CREM is involved in the pathogenesis of ulcerative colitis

He,

Zhou,

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Integrated single-cell and bulk RNA sequencing reveals CREM is involved in the pathogenesis of ulcerative colitis

He,

Zhou,

et al. 2024

Heliyon

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“…And TNFSF8, known as CD30 ligand (CD30L), is a membrane-associated glycoprotein belonging to the TNF superfamily. Previous studies have shown that CD30/CD30L signaling system has been implicated in the pathogenesis of several autoimmune and inflammatory conditions including rheumatoid arthritis and ulcerative colitis patients (30)(31)(32). However, there are very few studies exploring these genes in CAEBV in children.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis to screen the key genes in pediatric Chronic Active Epstein-Barr Virus infection

Yi Zhang,

Wenli Liu,

Yue Li

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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“…This, in turn, induces monocytes homing in a colitis mouse model via the CCL2/CCR2 axis. 55,56 Importantly, researches have indicated that the chemotactic cytokine PSMP is upregulated earlier than CCL2 in experimental colitis and promotes the expression of CCL2. This suggests that PSMP may initiate the early recruitment of circulating Ly6C hi CCR2 + monocytes to the tissue, working in concert with CCL2 and CCL7 to drive colitis.…”

Section: Migration and Recruitment Of Monocytes During Ibd Important ...mentioning

confidence: 99%

Origin and Function of Monocytes in Inflammatory Bowel Disease

Liao,

Liu,

Guo

et al. 2024

JIR

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Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic disease resulting from the interaction of various factors such as social elements, autoimmunity, genetics, and gut microbiota. Alarmingly, recent epidemiological data points to a surging incidence of IBD, underscoring an urgent imperative: to delineate the intricate mechanisms driving its onset. Such insights are paramount, not only for enhancing our comprehension of IBD pathogenesis but also for refining diagnostic and therapeutic paradigms. Monocytes, significant immune cells derived from the bone marrow, serve as precursors to macrophages (Mφs) and dendritic cells (DCs) in the inflammatory response of IBD. Within the IBD milieu, their role is twofold. On the one hand, monocytes are instrumental in precipitating the disease's progression. On the other hand, their differentiated offsprings, namely moMφs and moDCs, are conspicuously mobilized at inflammatory foci, manifesting either pro-inflammatory or anti-inflammatory actions. The phenotypic spectrum of these effector cells, intriguingly, is modulated by variables such as host genetics and the subtleties of the prevailing inflammatory microenvironment. Notwithstanding their significance, a palpable dearth exists in the literature concerning the roles and mechanisms of monocytes in IBD pathogenesis. This review endeavors to bridge this knowledge gap. It offers an exhaustive exploration of monocytes' origin, their developmental trajectory, and their differentiation dynamics during IBD. Furthermore, it delves into the functional ramifications of monocytes and their differentiated progenies throughout IBD's course. Through this lens, we aspire to furnish novel perspectives into IBD's etiology and potential therapeutic strategies.

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CD30L+ classical monocytes play a pro-inflammatory role in the development of ulcerative colitis in patients

Cited by 8 publications

References 54 publications

Integrated single-cell and bulk RNA sequencing reveals CREM is involved in the pathogenesis of ulcerative colitis

Integrated single-cell and bulk RNA sequencing reveals CREM is involved in the pathogenesis of ulcerative colitis

Bioinformatics analysis to screen the key genes in pediatric Chronic Active Epstein-Barr Virus infection

Origin and Function of Monocytes in Inflammatory Bowel Disease

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