CD200: A putative therapeutic target in cancer

Moreaux, Jérôme; Veyrune, Jean-Luc; Rème, Thierry; Vos, John De; Klein, Bernard

doi:10.1016/j.bbrc.2007.11.103

Cited by 106 publications

(86 citation statements)

References 36 publications

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“…В заключение следует отметить, что отсутствие экспрессии CD200 на опухолевых В-лимфоцитах исключает диагноз ХЛЛ и типичного ВКЛ, что со-гласуется со всеми изученными нами данными литературы [14][15][16][17][18][19][20][21]. Следовательно, при отсутствии или сниженной экспрессии СD200 следует направить диагностический поиск в сторону ЛМЗ и ЛЗМ.…”

Section: заключениеunclassified

“…Показано также про-гностическое значение экспрессии CD200 при ряде неоплазий гемопоэтической ткани [19,20]. СD200 рас-сматривается как потенциальный объект таргетной терапии при ХЛЛ и других неоплазиях [18, 21,22].…”

Section: Introductionunclassified

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Role of Superficial CD200 Marker in Differential Diagnosis of Malignant B-Cell Lymphoproliferative Diseases

Mirolyubova¹,

Stadnik²,

Nikulina³

et al. 2017

Клиническая онкогематология

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Background & Aims. Flow cytometry is successfully used for diagnosis of malignant lymphoproliferative disorders. However, there are atypical cases that are difficult to interpret; thus, new markers relevant for the differential diagnosis are to be searched for. The aim is to analyze CD200 expression in patients with B-cell lymphoproliferative disorders. Materials & Methods. 187 patients with chronic lymphocytic leukemia (CLL), 14 patients with mantle cell lymphoma (MCL), 9 patients with marginal zone lymphoma (MZL), and 5 patients with hairy cell leukemia (HCL) were enrolled in the study. Neoplasm was not confirmed in 12 subjects. The patients underwent the following tests: CBC, immunophenotyping of peripheral blood or bone marrow lymphocytes, and a cytogenetic test. In some cases, an additional immunohistochemical test of bone marrow trepanobiopsy or lymph node biopsy samples was required. Results. In all cases of CLL and HCL, the CD200 expression was positive; mean fluorescence intensity was higher in these cases as compared to other groups. Negative expression of CD200 prevailed in MCL patients; however, at the same time 2 cases of intermediate and positive expression were reported, both showing moderate fluorescence intensity values. CD200 expression was heterogeneous in MZL patients. Conclusion. The CD200 negative expression excludes typical HCL and CLL. Additional cytogenetic and immunnohistoсhemical tests should be performed in such cases to verify the diagnosis, first of all, MCL or MZL.

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Section: заключениеunclassified

Section: Introductionunclassified

Role of Superficial CD200 Marker in Differential Diagnosis of Malignant B-Cell Lymphoproliferative Diseases

Mirolyubova¹,

Stadnik²,

Nikulina³

et al. 2017

Клиническая онкогематология

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“…105,106 In addition, "don't eat me" signals such as CD47 and CD200 were upregulated in lung, breast, and prostate and bladder cancer. 107 Although these studies imply that tumors adopt evasion of apoptotic clearance as a cancer promoting strategy, several studies reported upregulation of different apoptotic recognition molecules such as PS 108,109 and calreticulin 104 in tumor cells, raising questions regarding the role of efficient apoptotic cell clearance in the context of tumorigenesis. Chronic inflammation is a key driver of tumorigenesis.…”

Section: Cancermentioning

confidence: 99%

Apoptotic membrane dynamics in health and disease

Julian¹,

Olson²

2015

CHC

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Apoptosis, also known as programmed cell death, is a fundamental homeostatic mechanism essential for normal embryonic development and the maintenance of healthy adult tissues. The processes that affect cell membrane dynamics during the tightly regulated apoptotic program have attracted considerable interest over the years. Distinct biochemical and structural alterations to plasma membrane composition and topography contribute to the efficient removal of cellular corpses. In this review, we will discuss these membrane alterations and their importance in maintaining cell and tissue homeostasis.

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“…− tumors had a longer event-free survival (EFS) after autologous stem cell transplantation than those with CD200 + disease [146].…”

Section: Importance Of Cd200:cd200r To Regulation Of Response Tomentioning

confidence: 99%

CD200:CD200R-Mediated Regulation of Immunity

Gorczynski

2012

ISRN Immunology

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The type 1 membrane glycoprotein CD200, widely expressed on multiple cells/tissues, uses a structurally similar receptor (CD200R1), whose expression is more restricted to cells of the myeloid and lymphoid lineages, to transmit signals affecting responses in multiple physiological systems. Thus CD200 expression is reported to exert effects on cancer growth, autoimmune and allergic disorders, infection, transplantation, bone development and homeostasis, and reproductive biology. It was initially thought, based on the idea that CD200R1 was mostly expressed on cells of myeloid origin, that CD200:CD200R1 interactions were primarily dedicated to controlling myeloid cell function. However additional members of the CD200R family have now also been identified, although their function(s) remain unclear, and CD200R1 itself is now known to be expressed by subsets of T cells and other cells. Together these observations add layers of complexity to our understanding of CD200-related regulation. In common with a number of physiological systems, the mechanism(s) of CD200-induced signaling seem to fit within a similar framework of opposing actions of kinases and phosphatases. This paper highlights the advances in our knowledge of immunoregulation achieved following CD200:CD200R interaction and the potential clinical applicability of that information.

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CD200: A putative therapeutic target in cancer

Cited by 106 publications

References 36 publications

Role of Superficial CD200 Marker in Differential Diagnosis of Malignant B-Cell Lymphoproliferative Diseases

Role of Superficial CD200 Marker in Differential Diagnosis of Malignant B-Cell Lymphoproliferative Diseases

Apoptotic membrane dynamics in health and disease

CD200:CD200R-Mediated Regulation of Immunity

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