CD14 C(−159)T Polymorphism Is a Risk Factor for Development of Pulmonary Tuberculosis

Rosas-Taraco, Adrián G.; Revol, A; Salinas-Carmona, Mario C.; Rendón, Adrián; Caballero-Olín, Guillermo; Arce-Mendoza, Alma Y.

doi:10.1086/522147

Cited by 60 publications

(69 citation statements)

References 47 publications

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“…Evaluation of the CD14 C(-159)T polymorphism showed that the TT genotype may be a risk factor for the development of TB. Similar results have been observed in a Mexican population (Rosas-Taraco et al, 2007). More studies are needed in other populations to confirm these results.…”

Section: Discussionsupporting

confidence: 88%

“…However, these authors found that the levels of mCD14/sCD14 in TB patients with the CD14-1145 GG genotype did not differ compared to other genotypes. Similar results were reported by Rosas-Taraco et al (2007) in a study of the CD14 C(-159)T polymorphism and development of pulmonary TB; although the CD14-159 TT genotype appeared to be a risk factor for TB, no differences were found between CD14-159 genotypes and the levels of either mCD14 or sCD14. These negative results may be due to the complexity of gene-environment interactions, which play an important role in microbial exposure and influence CD14 expression in TB patients and even in controls.…”

Section: Discussionsupporting

confidence: 87%

“…A soluble form of CD14 (sCD14) is abundant in serum and is derived from both secretion of CD14 and enzymatically cleaved glycosyl-phosphatidylinositol-anchored mCD14 (Zhang et al, 2008). Increased levels of CD14 have been reported in TB patients (Lawn et al, 2000;Rosas-Taraco et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population

My¹,

Xue²,

Zq³

et al. 2012

Genet. Mol. Res.

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ABSTRACT. Although the role of CD14 in mediating signals from Toll-like receptors to recognize Mycobacterium tuberculosis is known, how polymorphisms in this gene affect the susceptibility to develop tuberculosis are still not clear. We examined whether single nucleotide polymorphisms at positions -1145 and -159 in the promoter region of the CD14 gene are associated with tuberculosis in a Chinese Han population in a case-control study of 432 Chinese patients with tuberculosis and 404 ethnically matched healthy controls. Genotyping was performed to identify polymorphisms of the CD14 gene by PCR-DNA sequencing. Both the frequency of allele T in the C(-159)T polymorphism (odds ratio (OR) = 1.4; 95% confidence interval (95%CI) = 1.148-1.708) and allele G in the G(-1145)A polymorphism (OR = 1.512; 95%CI = 1.236-1.849) were significantly more frequent in cases than in controls. The frequencies of genotypes CC and CT in the C(-159)T polymorphism, as well as the frequencies of genotypes AA and AG, were lower in cases than in controls. Based on our results, we conclude that G(-1145)A and C(-159)T polymorphisms of CD14 are associated with decreased risk for the development of tuberculosis in the Chinese Han population.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 87%

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Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population

My¹,

Xue²,

Zq³

et al. 2012

Genet. Mol. Res.

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“…21 It is interesting to note that the IBD5 haplotype is distributed differently in Asian and European populations, and that the IBD5 risk haplotype in Europeans is very rare in Asians. 22 Although candidate genes including IL4 23 and CD14 24,25 have been studied in this particular region, roles of these genes in tuberculosis remain inconclusive. Small sample size and ethnicity of the study populations may partially explain these equivocal association results.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide SNP-based linkage analysis of tuberculosis in Thais

et al. 2008

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Tuberculosis, a potentially fatal infectious disease, affects millions of individuals annually worldwide. Human protective immunity that contains tuberculosis after infection has not been clearly defined. To gain insight into host genetic factors, nonparametric linkage analysis was performed using high-throughput microarray-based single nucleotide polymorphism (SNP) genotyping platform, a GeneChip array comprised 59 860 bi-allelic markers, in 93 Thai families with multiple siblings, 195 individuals affected with tuberculosis. Genotyping revealed a region on chromosome 5q showing suggestive evidence of linkage with tuberculosis (Z(lr) statistics ¼ 3.01, logarithm of odds (LOD) score ¼ 2.29, empirical P-value ¼ 0.0005), and two candidate regions on chromosomes 17p and 20p by an ordered subset analysis using minimum age at onset of tuberculosis as the covariate (maximum LOD score ¼ 2.57 and 3.33, permutation P-value ¼ 0.0187 and 0.0183, respectively). These results imply a new evidence of genetic risk factors for tuberculosis in the Asian population. The significance of these ordered subset results supports a clinicopathological concept that immunological impairment in the disease differs between young and old tuberculosis patients. The linkage information from a specific ethnicity may provide unique candidate regions for the identification of the susceptibility genes and further help elucidate the immunopathogenesis of tuberculosis.

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“…MD-2 knockout mice were reported to have increased resistance to endotoxemia but increased susceptibility to Salmonella typhimurium infection (Nagai et al, 2002). So far, several polymorphisms in the genes encoding CD14 and TLR4 have been considered to determine susceptibility to TB (Pacheco et al, 2004;Ferwerda et al, 2007;Rosas-Taraco et al, 2007). In view of the functional significance of genetic polymorphisms in CD14 and TLR4 genes, and their close relationship with MD-2, we hypothesized that certain polymorphisms in the MD-2 gene may also influence the development of TB.…”

Section: Introductionmentioning

confidence: 99%

Lack of association between MD-2 promoter gene variants and tuberculosis

Xue¹,

Zq²,

Hong³

et al. 2010

Genet. Mol. Res.

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DOI 10.4238/vol9-3gmr771 ABSTRACT. Myeloid differentiation-2 (MD-2) is an essential component of the CD14-TLR4/MD-2 receptor complex involved in microbial cell wall component recognition during infection. Genetic variations in the MD-2 gene may influence human susceptibility to infectious diseases. To date, a predisposition of MD-2 gene variants to contract tuberculosis has not been reported. We investigated whether MD-2 gene polymorphisms were associated with the development of tuberculosis in a Chinese population. The six common polymorphisms (rs11465996, rs1809442, rs1809441, rs1809440, rs16938754, and rs7842342) within the MD-2 gene promoter region were all detected in 259 patients with tuberculosis and 276 healthy control subjects by DNA sequencing. None of the allelic frequencies, haplotype patterns or genotype distributions of the assayed polymorphisms was found to be significantly different between patients and controls (P> 0.05). We conclude that these gene variants in the MD-2 gene promoter region are not associated with tuberculosis, and apparently do not play a role in susceptibility to tuberculosis in the Chinese population

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CD14 C(−159)T Polymorphism Is a Risk Factor for Development of Pulmonary Tuberculosis

Abstract: No association between TLR4 Asp299Gly and pulmonary TB was found. CD14 -159TT is a risk factor for development of pulmonary TB, whereas mCD14/sCD14 and mTLR4 are possible biomarkers for the prognosis for TB disease. CLINICAL TRIAL PROTOCOL ID: SA1168-05.

Cited by 60 publications

References 47 publications

Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population

Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population

Genome-wide SNP-based linkage analysis of tuberculosis in Thais

Lack of association between MD-2 promoter gene variants and tuberculosis

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