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Cited by 13 publications
(14 citation statements)
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References 47 publications
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“…Considering the low prevalence of the smoking habit in this young study population, the short duration of exposure to smoking, and the low number of cigarettes consumed, one would expect a minimal effect on the clinical attachment levels due to gene environment and gene‒lifestyle interactions. In fact, the young age of the participants, the use of a susceptible population for periodontitis, the inclusion of healthy subjects in the control group instead of only those presenting chronic gingivitis, the population‐based design, and the reduced exposure to risk factors for periodontitis such as smoking and diabetes only strengthen our findings . Similar strategies were used in other studies that explored conditions with low prevalence in the population, and have been demonstrated of value to uncover genotype/phenotype relationships without enrolling an extensive sample …”
Section: Discussionsupporting
confidence: 62%
“…Considering the low prevalence of the smoking habit in this young study population, the short duration of exposure to smoking, and the low number of cigarettes consumed, one would expect a minimal effect on the clinical attachment levels due to gene environment and gene‒lifestyle interactions. In fact, the young age of the participants, the use of a susceptible population for periodontitis, the inclusion of healthy subjects in the control group instead of only those presenting chronic gingivitis, the population‐based design, and the reduced exposure to risk factors for periodontitis such as smoking and diabetes only strengthen our findings . Similar strategies were used in other studies that explored conditions with low prevalence in the population, and have been demonstrated of value to uncover genotype/phenotype relationships without enrolling an extensive sample …”
Section: Discussionsupporting
confidence: 62%
“… 12 , 29 In this regard, we can assume that elevated IFN-γ levels have influence in the over expression of IFN-γ R2 in endothelial cells in gingival tissue samples from CP patients. 7 , 14 , 15 , 18 , 20 , 28 However, we found no significant correlation between IFN-γ levels and IFN- γR2 expression in the endothelial cells of CP patients.…”
Section: Discussioncontrasting
confidence: 72%
“…The inclusion of theoretically resistant individuals (i.e., presenting deep caries without periapical lesions) have been found to improve the odds of identifying genetic factors that potentially contribute to increasing the risk to periapical lesions development (100, 101). A similar approach has been used in chronic periodontitis, with the use of chronic gingivitis subjects as a theoretically resistant population (99, 102).…”
Section: Apical Periodontitismentioning
confidence: 99%