Cavamax W7 Composite Ethosomal Gel of Clotrimazole for Improved Topical Delivery: Development and Comparison with Ethosomal Gel

Akhtar, Nida; Pathak, Kamla

doi:10.1208/s12249-012-9754-y

Cited by 79 publications

(52 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The size of these vesicles should be reduced to ,200 nm or 300 nm to be suitable for this route of administration. 14,40,92 Therefore, in all the aforementioned methods except the reverse-phase evaporation method, the prepared ethosomal systems are subjected to different further processing to get the required size or lamellarity.…”

Section: Ethosomal System Size and Lamellaritymentioning

confidence: 99%

“…15 Some authors have reported the same superior properties of ethosomal gels for different drugs/agents over traditional gels. 14,18,96 Interestingly, it was found that the drug-release rate from the ethosomal suspension was faster than from ethosomal gel, due to the high viscosity of the gel. [97][98][99] The preparation and evaluation of ethosomal patches are more complicated than for ethosomal gels, as molds are required for their preparation.…”

Section: Ethosomal Gelsmentioning

confidence: 99%

See 1 more Smart Citation

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Abdulbaqi

Darwis

Khan

et al. 2016

IJN

310

215

View full text Add to dashboard Cite

Ethosomal systems are novel lipid vesicular carriers containing a relatively high percentage of ethanol. These nanocarriers are especially designed for the efficient delivery of therapeutic agents with different physicochemical properties into deep skin layers and across the skin. Ethosomes have undergone extensive research since they were invented in 1996; new compounds were added to their initial formula, which led to the production of new types of ethosomal systems. Different preparation techniques are used in the preparation of these novel carriers. For ease of application and stability, ethosomal dispersions are incorporated into gels, patches, and creams. Highly diverse in vivo models are used to evaluate their efficacy in dermal/transdermal delivery, in addition to clinical trials. This article provides a detailed review of the ethosomal systems and categorizes them on the basis of their constituents to classical ethosomes, binary ethosomes, and transethosomes. The differences among these systems are discussed from several perspectives, including the formulation, size, ζ-potential (zeta potential), entrapment efficiency, skin-permeation properties, and stability. This paper gives a detailed review on the effects of ethosomal system constituents, preparation methods, and their significant roles in determining the final properties of these nanocarriers. Furthermore, the novel pharmaceutical dosage forms of ethosomal gels, patches, and creams are highlighted. The article also provides detailed information regarding the in vivo studies and clinical trials conducted for the evaluation of these vesicular systems.

show abstract

Section: Ethosomal System Size and Lamellaritymentioning

confidence: 99%

Section: Ethosomal Gelsmentioning

confidence: 99%

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Abdulbaqi

Darwis

Khan

et al. 2016

IJN

310

215

View full text Add to dashboard Cite

show abstract

“…Then the zone of inhibition of each well was visualized after the incubation period of 24 hrs. The radius of zone of inhibition was calculated and compared to the zone of inhibition of control formulation (Akhtar et al 2012). …”

Section: Antifungal Activitymentioning

confidence: 99%

Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application

Ubaid

Ilyas

Mir

et al. 2016

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effect of independent variables i.e. coconut oil (X 1 ), pistachio oil (X 2 ) and sodium lauryl sulphate (X 3 ) at various dependent variables i.e. flux (Y 1 ), lag time (Y 2 ), diffusion coefficient (Y 3 ), permeability coefficient (Y 4 ), and input rate (Y 5 ) of clotrimazole gel formulations. Ex vivo skin permeation study was performed through rat skin by using modified Franz diffusion cell system. Optimized formulation F8 exhibited highest flux 2.17 µg/cm 2 /min, permeability coefficient 0.0019 cm/min and input rate 1.543 µg/cm 2 /min, along with moderate lag time 77.27 min and diffusion coefficient 0.063 cm 2 /min, which is further supported by anti-fungal activity that exhibited more prominent zone of inhibition against Candida albicans, Aspergillus niger and Mucor. Thus, it can be concluded that permeation of clotrimazole gel was enhanced by various combination of coconut oil, pistachio oil and sodium lauryl sulphate but optimized formulation F8 containing 0.4 ml pistachio oil, 0.8 ml coconut oil and 0.04 g of SLS exhibited more pronounced and promising effect through rat skin.

show abstract

“…drugs like piroxicam [20] , carvedilol [21] , finasteride [22] and clotrimazole [23] . Also, ethosomes can be used to increase the bioavailability of natural products [24] .…”

Section: In Vitro Penetration and Bioavailability Of Novel Transdermamentioning

confidence: 99%

In vitro Penetration and Bioavailability of Novel Transdermal Quercetin-loaded Ethosomal Gel

Ramadon¹,

Anwar²,

Harahap³

2017

pharmaceutical-sciences

View full text Add to dashboard Cite

Quercetin has been widely used to treat many diseases because of its high antioxidant activity. However, it has low oral bioavailability and penetration through the skin. The aim of this research was to enhance penetration and bioavailability of quercetin using transdermal ethosomal gel. Three ethosomal formulae, E1 (1 %), E2 (1.5 %) and E3 (2 %) with different concentration of quercetin were prepared using thin-film hydration method. Their physical properties were characterized, and then a selected ethosomal formula was incorporated into a gel dosage form. Two gels, one ethosomal and the other non-ethosomal were prepared. In vitro penetration using Franz diffusion cells and bioavailability study in Sprague Dawley male rats were carried out. Results showed that E2 was the chosen formula to be incorporated into the gel dosage form. According to the in vitro penetration study, the diffusion flux of quercetin from the ethosomal and non-ethosomal gels were 343.35±17.69 ng/cm 2 /h and 120.68±11.92 ng/cm 2 /h, respectively (P<0.05). In the bioavailability study, ethosomal gel showed higher maximum concentration (C max ) and area under curve (AUC 0-t ) when compared to non-ethosomal gel and oral suspension. C max from the ethosomal gel, nonethosomal gel, and oral suspension were 413.49±28.64, 189.46±49.68, and 61.92±14.31 ng/ml, respectively (P<0.05). AUC 0-t from the ethosomal gel, non-ethosomal gel, and oral suspension were 4035.15±560.60, 584.87±265.46, and 431.21±239.85, respectively (P<0.05). In conclusion, ethosomal gel could increase penetration and bioavailability of quercetin compared to non-ethosomal gel.

show abstract

Cavamax W7 Composite Ethosomal Gel of Clotrimazole for Improved Topical Delivery: Development and Comparison with Ethosomal Gel

Cited by 79 publications

References 24 publications

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application

In vitro Penetration and Bioavailability of Novel Transdermal Quercetin-loaded Ethosomal Gel

Contact Info

Product

Resources

About