Causes of deaths in an oncologic intensive care unit: A clinical and pathological study of 34 autopsies

Premortem clinical diagnoses and postmortem autopsy findings: discrepancies in critically ill cancer patients

“…Opportunistic infections accounted for the majority (67%) of class I discrepancies. In contrast to previous studies that showed a predominance of fungal infections in immunocompromised patients [ 1 , 23 ], the opportunistic infections in our study were represented by various pathogens (viral, fungal, and parasitic) (Table 2 ). We ascribe these findings to the increasing exposure of our patients to broad-spectrum antimicrobials that effect the terminal flora and promote the emergence of more virulent and resistant nosocomial infections [ 26 , 27 ].…”

“…We ascribe these findings to the increasing exposure of our patients to broad-spectrum antimicrobials that effect the terminal flora and promote the emergence of more virulent and resistant nosocomial infections [ 26 , 27 ]. Our findings reinforce the difficulty of diagnosing different infectious entities such as nosocomial pneumonia and fungal and viral infections in critically ill patients [ 23 , 24 ]. We suggest that novel microbiologic identification with non-culture techniques, including serologic tests, immunohistologic methods, polymerase chain reaction, and molecular-probing technologies, be introduced to aid in the rapid diagnosis of these virulent infections [ 28 , 29 ].…”

Premortem clinical diagnoses and postmortem autopsy findings: discrepancies in critically ill cancer patients

“…Opportunistic infections accounted for the majority (67%) of class I discrepancies. In contrast to previous studies that showed a predominance of fungal infections in immunocompromised patients [ 1 , 23 ], the opportunistic infections in our study were represented by various pathogens (viral, fungal, and parasitic) (Table 2 ). We ascribe these findings to the increasing exposure of our patients to broad-spectrum antimicrobials that effect the terminal flora and promote the emergence of more virulent and resistant nosocomial infections [ 26 , 27 ].…”

“…We ascribe these findings to the increasing exposure of our patients to broad-spectrum antimicrobials that effect the terminal flora and promote the emergence of more virulent and resistant nosocomial infections [ 26 , 27 ]. Our findings reinforce the difficulty of diagnosing different infectious entities such as nosocomial pneumonia and fungal and viral infections in critically ill patients [ 23 , 24 ]. We suggest that novel microbiologic identification with non-culture techniques, including serologic tests, immunohistologic methods, polymerase chain reaction, and molecular-probing technologies, be introduced to aid in the rapid diagnosis of these virulent infections [ 28 , 29 ].…”

Alterações histopatológicas pulmonares em pacientes com insuficiência respiratória aguda: um estudo em autopsias

“…(9) We also found that ARF was more common in patients 50 years of age or older. As described by other authors, (8,11,(13)(14)(15)(16)(17)(18) infections were another common complication of ARF in our study. Our study specifically showed that patients who developed ARF had underlying diseases such as AIDS (31.4%), sepsis (11.7%), cirrhosis (11.5%), pulmonary thromboembolism (5.7%), AMI (5.5%), cerebrovascular accident (4.6%), tuberculosis (3.6%), cancer (2.3%), chronic kidney failure (1.9%) and leukemia (0.2%).…”

Can low autopsy rates be increased? Yes, we can! Should postmortem examinations in oncology be performed? Yes, we should! A postmortem analysis of oncological cases

“…Regarding clinical autopsies, there are only few studies dealing with postmortem examinations in oncological cases and most of them only included cancer patients who died at an intensive care unit. Major discrepancy rates of 21-59% were reported in this collective [12,25] which is more or less comparable to the rates of our study. At the end of a cancer patient's life, the extent to which diagnostic procedures are used might be smaller compared to other collectives.…”

Premortem clinical diagnoses and postmortem autopsy findings: discrepancies in critically ill cancer patients

“…Opportunistic infections accounted for the majority (67%) of class I discrepancies. In contrast to previous studies that showed a predominance of fungal infections in immunocompromised patients [ 1 , 23 ], the opportunistic infections in our study were represented by various pathogens (viral, fungal, and parasitic) (Table 2 ). We ascribe these findings to the increasing exposure of our patients to broad-spectrum antimicrobials that effect the terminal flora and promote the emergence of more virulent and resistant nosocomial infections [ 26 , 27 ].…”

“…We ascribe these findings to the increasing exposure of our patients to broad-spectrum antimicrobials that effect the terminal flora and promote the emergence of more virulent and resistant nosocomial infections [ 26 , 27 ]. Our findings reinforce the difficulty of diagnosing different infectious entities such as nosocomial pneumonia and fungal and viral infections in critically ill patients [ 23 , 24 ]. We suggest that novel microbiologic identification with non-culture techniques, including serologic tests, immunohistologic methods, polymerase chain reaction, and molecular-probing technologies, be introduced to aid in the rapid diagnosis of these virulent infections [ 28 , 29 ].…”

Alterações histopatológicas pulmonares em pacientes com insuficiência respiratória aguda: um estudo em autopsias

“…(9) We also found that ARF was more common in patients 50 years of age or older. As described by other authors, (8,11,(13)(14)(15)(16)(17)(18) infections were another common complication of ARF in our study. Our study specifically showed that patients who developed ARF had underlying diseases such as AIDS (31.4%), sepsis (11.7%), cirrhosis (11.5%), pulmonary thromboembolism (5.7%), AMI (5.5%), cerebrovascular accident (4.6%), tuberculosis (3.6%), cancer (2.3%), chronic kidney failure (1.9%) and leukemia (0.2%).…”

Can low autopsy rates be increased? Yes, we can! Should postmortem examinations in oncology be performed? Yes, we should! A postmortem analysis of oncological cases

“…Regarding clinical autopsies, there are only few studies dealing with postmortem examinations in oncological cases and most of them only included cancer patients who died at an intensive care unit. Major discrepancy rates of 21-59% were reported in this collective [12,25] which is more or less comparable to the rates of our study. At the end of a cancer patient's life, the extent to which diagnostic procedures are used might be smaller compared to other collectives.…”

Premortem clinical diagnoses and postmortem autopsy findings: discrepancies in critically ill cancer patients

“…Opportunistic infections accounted for the majority (67%) of class I discrepancies. In contrast to previous studies that showed a predominance of fungal infections in immunocompromised patients [ 1 , 23 ], the opportunistic infections in our study were represented by various pathogens (viral, fungal, and parasitic) (Table 2 ). We ascribe these findings to the increasing exposure of our patients to broad-spectrum antimicrobials that effect the terminal flora and promote the emergence of more virulent and resistant nosocomial infections [ 26 , 27 ].…”

“…We ascribe these findings to the increasing exposure of our patients to broad-spectrum antimicrobials that effect the terminal flora and promote the emergence of more virulent and resistant nosocomial infections [ 26 , 27 ]. Our findings reinforce the difficulty of diagnosing different infectious entities such as nosocomial pneumonia and fungal and viral infections in critically ill patients [ 23 , 24 ]. We suggest that novel microbiologic identification with non-culture techniques, including serologic tests, immunohistologic methods, polymerase chain reaction, and molecular-probing technologies, be introduced to aid in the rapid diagnosis of these virulent infections [ 28 , 29 ].…”

Alterações histopatológicas pulmonares em pacientes com insuficiência respiratória aguda: um estudo em autopsias

“…(9) We also found that ARF was more common in patients 50 years of age or older. As described by other authors, (8,11,(13)(14)(15)(16)(17)(18) infections were another common complication of ARF in our study. Our study specifically showed that patients who developed ARF had underlying diseases such as AIDS (31.4%), sepsis (11.7%), cirrhosis (11.5%), pulmonary thromboembolism (5.7%), AMI (5.5%), cerebrovascular accident (4.6%), tuberculosis (3.6%), cancer (2.3%), chronic kidney failure (1.9%) and leukemia (0.2%).…”

Can low autopsy rates be increased? Yes, we can! Should postmortem examinations in oncology be performed? Yes, we should! A postmortem analysis of oncological cases

“…Regarding clinical autopsies, there are only few studies dealing with postmortem examinations in oncological cases and most of them only included cancer patients who died at an intensive care unit. Major discrepancy rates of 21-59% were reported in this collective [12,25] which is more or less comparable to the rates of our study. At the end of a cancer patient's life, the extent to which diagnostic procedures are used might be smaller compared to other collectives.…”