Causes and Phenotypes of Work-Related Asthma

Maestrelli, Piero; Henneberger, Paul K.; Tarlo, Susan M.; Mason, Paola; Boschetto, Pierà

doi:10.3390/ijerph17134713

Cited by 30 publications

(25 citation statements)

References 47 publications

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“…They can be categorized as sensitizers (e.g., flours, latex, diisocyanates) and irritants [4][5][6]. According to the causative substance and the pathogenic mechanism, occupational asthma is classified as sensitizer-induced asthma or irritant-induced asthma [4,7,8]. The first type involves an immunologic mechanism and appears after a latency period [8].…”

Section: Introductionmentioning

confidence: 99%

“…According to the causative substance and the pathogenic mechanism, occupational asthma is classified as sensitizer-induced asthma or irritant-induced asthma [4,7,8]. The first type involves an immunologic mechanism and appears after a latency period [8]. The second type corresponds to asthma caused by non-immunological irritant mechanisms, which have not been precisely identified yet.…”

Section: Introductionmentioning

confidence: 99%

“…The second type corresponds to asthma caused by non-immunological irritant mechanisms, which have not been precisely identified yet. Irritant-induced asthma appears after a single acute exposure to very high levels of irritants (reactive airway dysfunction syndrome (RADS), or Brooks' syndrome) or may occur with a delayed onset after repeated low-dose exposures to irritants [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort

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Iwatsubo

et al. 2021

IJERPH

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Solvents are used in many workplaces and may be airway irritants but few studies have examined their association with asthma. We studied this question in CONSTANCES (cohort of ‘CONSulTANts des Centres d’Examens de Santé’), a large French cohort. Current asthma and asthma symptom scores were defined by participant-reported respiratory symptoms, asthma medication or attacks, and the sum of 5 symptoms, in the past 12 months, respectively. Lifetime exposures to 5 organic solvents, paints and inks were assessed by questionnaire and a population-based Job-Exposure Matrix (JEM). Cross-sectional associations between exposures and outcomes were evaluated by gender using logistic and negative binomial regressions adjusted for age, smoking habits and body mass index. Analyses included 115,757 adults (54% women, mean age 47 years, 9% current asthma). Self-reported exposure to ≥1 solvent was significantly associated with current asthma in men and women, whereas using the JEM, a significant association was observed only in women. Significant associations between exposures to ≥1 solvent and asthma symptom score were observed for both self-report (mean score ratio, 95%CI, women: 1.36, 1.31–1.42; men: 1.34, 1.30–1.40) and JEM (women: 1.10, 1.07–1.15; men: 1.14, 1.09–1.18). Exposure to specific solvents was significantly associated with higher asthma symptom score. Occupational exposure to solvents should be systematically sought when caring for asthma.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort

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Letellier

Iwatsubo

et al. 2021

IJERPH

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“…No Quadro 1 encontram-se descritos os agentes sensibilizantes mais prevalentes, divididos segundo o peso molecular, e incluindo profissões e locais de trabalho nos quais são mais frequentemente encontrados. (20)(21)(22)(23)(24) Entre os agentes de alto peso molecular destacam-se as proteínas de origem vegetal e animal. Entre os agentes de baixo peso molecular incluem-se compostos orgânicos e inorgânicos que podem funcionar como haptenos, sendo que alguns deles têm seus mecanismos imunomediados por IgE, como sais de platina (catalisadores industriais), anidridos trimelítico e ftálico (presentes em tintas e selantes), persulfato (henna para cabelo), corantes reativos e, com menor frequência, di-isocianatos.…”

Section: Agentes Sensibilizantesunclassified

Work-related asthma

et al. 2021

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Work-related asthma (WRA) is highly prevalent in the adult population. WRA includes occupational asthma (OA), which is asthma caused by workplace exposures, and work-exacerbated asthma (WEA), also known as work-aggravated asthma, which is preexisting or concurrent asthma worsened by workplace conditions. In adults, the estimated prevalence of OA is 16.0%, whereas that of WEA is 21.5%. An increasing number of chemicals used in industrial production, households, and services are associated with the incidence of adult-onset asthma attributable to exposure to chemicals. This review article summarizes the different types of WRA and describes diagnostic procedures, treatment, prevention, and approaches to patient management. It is not always easy to distinguish between OA and WEA. It is important to establish a diagnosis (of sensitizer-/irritant-induced OA or WEA) in order to prevent worsening of symptoms, as well as to prevent other workers from being exposed, by providing early treatment and counseling on social security and work-related issues.

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“…2 Work-related asthma (WRA) covers conditions having symptoms and signs compatible with asthma and a relationship with exposures in the workplace. 3 It encompasses subtypes of sensitizer-and irritant-induced occupational asthma and work-exacerbated asthma. 4,5 Diagnostic tests aim to identify these WRA subtypes, but in practice doing so can be difficult.…”

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confidence: 99%