Causal relationship between folic acid and prostate cancer risk: Insights from Mendelian randomization analysis
Xiaoxiao Guo,
Fengbo Zhang,
Gangyue Hao
Abstract:ObjectiveFolic acid is a commonly used dietary supplement of trace element, but it may increase the risk of prostate cancer (PCa). The aim of this study was to investigate the causal relationship between PCa and folic acid supplementation, as well as dietary folate equivalents, using Mendelian randomization (MR) analysis.MethodsThe Genome‐Wide Association Study (GWAS) data of folic acid supplementation and dietary folate equivalents were selected from UK Biobank. Meta‐analysis of GWASs of PCa was obtained from… Show more
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