Cauda equina tumor with ependymal and paraganglionic differentiation

Caccamo, Darío V.; Ho, Khang-Loon; García, Julio Herrero

doi:10.1016/0046-8177(92)90356-8

Cited by 25 publications

(16 citation statements)

References 7 publications

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“…Histopathological similarity between PGs and ependymomas in the cauda equina region may lead to diagnostic confusion especially when a tumor shows both paraganglionic and ependymal differentiation (2) or when the lesion contains areas with ependymoma-like morphology but still revealing PG-like immunohistochemistry. The latter condition is quite rare and to our knowledge, only a few cases of PGs with ependymoma-like histology have been reported to date (17,19,20).…”

Section: Discussionmentioning

confidence: 99%

“…In this context, CD99 immunoreactivity in our case may in a way give a clue for the histogenesis of this rare morphology in PG. Another speculation on the histogenesis of this tumor was made as it might have originated from elements normally found in the cauda equina/filum terminale such as ependymal cells, ganglionic neurons and neuroblasts (2). These authors …”

Section: Discussionmentioning

confidence: 99%

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Cauda equina paraganglioma with ependymoma-like histology: a case presentation

Mıdı¹,

Yener²,

Sav³

et al. 2010

Turkish Neurosurgery

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Paraganglioma affecting the cauda equina region is very rare and can be misinterpreted as an ependymoma which is more common at this site. A 38-year-old woman with a paraganglioma in the cauda equina is presented. MRI revealed a well-circumscribed, intradural, extramedullary tumor nodule with the dimensions of 2.5x1x1 cm. The patient underwent L3 laminectomy and total excision of the tumor. The tumor was diagnosed as ependymoma and the patient was decided to undergo adjuvant radiotherapy. The patient applied to our medical center for a second opinion. Histopathologically, her tumor was found to be a paraganglioma with ependymal features. Therefore no adjuvant therapy was applied. There is no evidence of recurrence or metastases for 15 months after her operation. Paraganglioma in the cauda equina/ filum terminale is very rare and can be misdiagnosed as ependymoma especially when it exhibits ependymoma-like histology. This rare form of paraganglioma behaves like a WHO grade I tumor of CNS like classic paraganglioma. No recurrence or metastasis is expected when it is totally resected. Morphology can be misleading hence immunohistochemistry and/or ultrastructural study is necessary for correct diagnosis.KeywoRds: Paraganglioma, Ependymoma-like histology, Filum terminale, Immunohistochemistry, CD 99 ÖZKauda ekuina yerleşimli paraganglioma oldukça nadir olup, bu lokalizasyonda daha sık görülen ependimoma ile karışabilir. Bu çalışmada kauda ekuina yerleşimli, ependimoma benzeri histoloji gösteren paraganglioma olgusunu sunmayı amaçladık. 38 yaşındaki bayan hastaya, MR yöntemi ile saptanan 2,5x1x1 cm boyutlarda, intradural-ekstramedüller yerleşimli, iyi sınırlı kitle nedeniyle bir başka merkezde L3 laminektomi ve kitle eksizyonu uygulanmıştır. Burada tümor, ependimoma olarak rapor edilmiştir ve hastaya adjuvan radyoterapi verilmesi kararı alınmıştır. Hasta, tanı ve tedavisi konusunda ikinci bir görüş almak üzere merkezimize başvurmuştur. Merkezimizde yapılan patolojik inceleme ve immünohistokimyasal boyamalar sonucu, tümörün ependimoma benzeri histoloji gösteren paraganglioma olduğu rapor edilmiştir. Bunun üzerine hastanın ek tedavi almamasına karar verilmiştir. Hastanın, ameliyatından sonraki 15 aylık izlemi sonucunda nüks ya da metastaz bulgusu izlenmemektedir. Kauda ekuina/filum terminale yerleşimli paraganglioma oldukça nadir olup özellikle ependimoma-benzeri histoloji gösteren olan olgular, ependimoma ile karışabilmektedir. Bu tür olgularda klinik seyir, SSS tümörleri-WHO Sınıflamasında yeralan derece I tümörlerdeki gibi olup, tedavide kitlenin total eksizyonunun yapılması yeterlidir. Morfolojik bulgular yanıltıcı olabileceği için immünohistokimyasal ve/veya ultrastrüktürel yöntemler, kesin tanı için gereklidir.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cauda equina paraganglioma with ependymoma-like histology: a case presentation

Mıdı¹,

Yener²,

Sav³

et al. 2010

Turkish Neurosurgery

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“…However, Systemic paragangliomas may be multifocal, The association of spinal paraganglioma with brain tumors, spinal epidural haemangioma, syringomyelia, and intramedullary cysts are encountered ( 228,229,230,231), but these associations may be coincidental. Several autosomal dominant inherited syndromes predispose to paraganglioma or phaeochromocytomaas noted in von Hippel-Lindau disease (VHL); multiple endocrine neoplasia type 2 (RET mutations); neurofibromatosis type 1 (NF1).…”

Section: Genetics Susceptibilitymentioning

confidence: 99%

“…Chief cells are marked with Neuron-specific enolase (NSE), synaptophysin and chromogranin (228,229). Chromogranin A reactivity parallels the Grimelius (argyrophil) reaction (219,223,224).…”

Section: Immunohistochemistrymentioning

confidence: 99%

Neuronal and Mixed Neuronal-Glial Tumors of the Central Nervous System

Barbarawi¹,

Allouh²,

Qudsieh³

2012

Histopathology - Reviews and Recent Advances

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“…Furthermore, they exhibit ependymal characteristics (discussed previously) and may contain distinctive microtubular aggregates within their rough endoplasmic reticulum at the fine-structural level [48,49]. A unique tumor of the cauda equina with evidence of differentiation along ependymal and paraganglionic lines has been described [50].…”

Section: Myxopapillary Ependymomamentioning

confidence: 99%

Ependymal Tumors: A Review of Their Diagnostic Surgical Pathology

Rosenblum

1998

Pediatr Neurosurg

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Cauda equina tumor with ependymal and paraganglionic differentiation

Cited by 25 publications

References 7 publications

Cauda equina paraganglioma with ependymoma-like histology: a case presentation

Cauda equina paraganglioma with ependymoma-like histology: a case presentation

Neuronal and Mixed Neuronal-Glial Tumors of the Central Nervous System

Ependymal Tumors: A Review of Their Diagnostic Surgical Pathology

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