Cationic Polymers Enable Internalization of Negatively Charged Chemical Probes into Bacteria
Hannah K. Lembke,
Adeline Espinasse,
Mckenna G. Hanson
et al.
Abstract:The bacterial cell envelope provides a protective barrier that is challenging for small molecules and biomolecules to cross. Given the anionic nature of both Gram-positive and Gram-negative bacterial cell envelopes, negatively charged molecules are particularly difficult to deliver into these organisms. Many strategies have been employed to penetrate bacteria, ranging from reagents such as cell-penetrating peptides, enzymes, and metal-chelating compounds to physical perturbations. While cationic polymers are k… Show more
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