2019
DOI: 10.3390/pharmaceutics11020050
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Abstract: Cationic niosomes have become important non-viral vehicles for transporting a good number of small drug molecules and macromolecules. Growing interest shown by these colloidal nanoparticles in therapy is determined by their structural similarities to liposomes. Cationic niosomes are usually obtained from the self-assembly of non-ionic surfactant molecules. This process can be governed not only by the nature of such surfactants but also by others factors like the presence of additives, formulation preparation a… Show more

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Cited by 64 publications
(60 citation statements)
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References 129 publications
(175 reference statements)
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“…Cationic niosomes are selfassembled vesicular nanovehicles, similar to liposomes, with encouraging properties for gene delivery applications. To mention a few, the chemical structure of niosomes makes it possible to provide more stable and less cytotoxic formulations at a low cost [13]. The amphiphilic nature of nonionic surfactants enable niosomes to trap both hydrophobic and hydrophilic compounds [14].The cationic part here is the hydrochloride salt of the cationic lipid 2,3-di (tetradecyloxy) propan-1-amine (D).…”
Section: Introductionmentioning
confidence: 99%
“…Cationic niosomes are selfassembled vesicular nanovehicles, similar to liposomes, with encouraging properties for gene delivery applications. To mention a few, the chemical structure of niosomes makes it possible to provide more stable and less cytotoxic formulations at a low cost [13]. The amphiphilic nature of nonionic surfactants enable niosomes to trap both hydrophobic and hydrophilic compounds [14].The cationic part here is the hydrochloride salt of the cationic lipid 2,3-di (tetradecyloxy) propan-1-amine (D).…”
Section: Introductionmentioning
confidence: 99%
“…Once niosomes have been prepared using any of the previously above-mentioned techniques, the corresponding nioplexes can be obtained after the addition of a solution of the pertinent genetic material to the colloidal suspension of niosomes ( Figure 3). Due to the electrostatic interactions between the positively charged amine groups of the cationic lipids incorporated into the niosome vesicles and the negatively charged phosphate groups of the genetic material, nioplexes can be easily obtained at different cationic lipid/genetic material ratios [76]. In the case the obtained niosomes are not going to be used soon, they can be stored at 4 • C during several weeks, without affecting the main physicochemical parameters that influence the gene delivery process [9].…”
Section: Niosome Preparation Methodsmentioning
confidence: 99%
“…Compared to liposome counterparts, niosomes are recognized for their higher chemical and storage stability, due to the presence of non-ionic surfactants in their structure [75]. In addition, niosomes can be easily prepared at a low cost, and they are less toxic than liposomes due to the presence of non-ionic surfactants [76,77]. All these characteristics justify the research on niosomes as an interesting platform for gene delivery applications.…”
Section: Niosome Nanoparticles For Gene Deliverymentioning
confidence: 99%
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“…Recently, cationic gemini surfactants have attracted special attention as efficient transfection agents in vitro and promising alternatives to viral vectors in gene therapy [4][5][6]. Successful gene therapy crucially depends on the development of effective vectors, especially for the safe introduction of the selected gene into living cells.…”
Section: Introductionmentioning
confidence: 99%