Cationic micelle delivery of Trp2 peptide for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses

Zeng, Qin; Jiang, Hao; Wang, Ting; Zhang, Zhirong; Gong, Tao; Sun, Xun

doi:10.1016/j.jconrel.2014.12.024

Cited by 88 publications

(76 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IFNg/CD8 + T cells seem to activate Th1 response while IL-4 expressing CD4 + T cells seem to induce Th2 response (Doria-Rose & Haigwood, 2003). These results were consistent with a previous report that cationic micelles PSA could promote cytokines secretion as compared to peptide alone (Zeng et al, 2014). The PEI-25k/mGag group could also induce high secretion of pro-inflammatory cytokines in spleen supernatants.…”

Section: Discussionsupporting

confidence: 93%

“…PSA/mRNA nanoparticles PSA was synthesized by amide reaction and was reported previously by our group (Zeng et al, 2014). Briefly, stearic acid (71.2 mg) was dissolved in 10 mL DMSO, then, EDCI (57.5 mg) and NHS (34.5 mg) were added.…”

Section: In Vitro Mrna Transcriptionmentioning

confidence: 99%

“…We had previously reported that stearic acid and branched PEI-2k conjugates (PSA) could form self-assemble cationic micelles. The micelles were able to encapsulate tyrosine's-related protein to peptide and accumulate in the draining lymph nodes after subcutaneous injection (Zeng et al, 2014). The objective of the present work was to evaluate the capability of PSA cationic micelles for mRNA vaccines delivery.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Induction of HIV-1 gag specific immune responses by cationic micelles mediated delivery of gag mRNA

et al. 2015

Self Cite

View full text Add to dashboard Cite

In recent years, mRNA-based vaccines have emerged to be a great alternative to DNA-based vaccines due to the safety of not inserting into host genome. However, mRNA molecules are single-stranded nucleic acids that are vulnerable under RNase existing in human skin and tissues. In this study, a self-assembled cationic nanomicelles based on polyethyleneimine-stearic acid (PSA) copolymer were developed to delivery HIV-1 gag encoding mRNA to dendritic cells and BALB/c mice. We evaluated the transfection efficiency and cell uptake efficiency of naked EGFP mRNA, PSA, PEI-2k and PEI-25k nanoparticles format on DC2.4 cell lines. Immune responses after sub-cutaneous administration of gag mRNA to BALB/c mice were notably induced by PSA as compared with naked gag mRNA. We found the PSA/mRNA nanomicelles were potent systems that can effectively deliver mRNA and induce antigen-specific immune response, stimulating various new vaccine strategies using mRNA.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: In Vitro Mrna Transcriptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Induction of HIV-1 gag specific immune responses by cationic micelles mediated delivery of gag mRNA

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nevertheless, this charge effect may be counterbalanced by the appropriate adjustment of the particle size. For example, Zeng et al showed that 30 nm cationic micelles were able to self-drain to the closest lymph nodes [54]. Similarly, Kim et al have reported that both small cationic and anionic poly(γ-glutamic acid)-based nanosystems (30–60 nm) were able to self-drain to the closest lymph node [55].…”

Section: Access Of Nanostructures To Target Cellsmentioning

confidence: 99%

Modulating the immune system through nanotechnology

Dacoba

Ana

Torres

et al. 2017

Seminars in Immunology

100

View full text Add to dashboard Cite

Nowadays, nanotechnology-based modulation of the immune system is presented as a cutting-edge strategy, which may lead to significant improvements in the treatment of severe diseases. In particular, efforts have been focused on the development of nanotechnology-based vaccines, which could be used for immunization or generation of tolerance. In this review, we highlight how different immune responses can be elicited by tuning nanosystems properties. In addition, we discuss specific formulation approaches designed for the development of anti-infectious and anti-autoimmune vaccines, as well as those intended to prevent the formation of antibodies against biologicals.

show abstract

“…Furthermore, pH‐sensitive Schiff base bonds can be created in order to increase the cytosolic release of the antigen and enhance the cross‐presentation process . PEI is a cationic polymer that has been widely studied due to its capacity to be efficiently uptaken by cells and induce the cross‐presentation of the antigen on MHC class I molecules via both endosome escape and a lysosomal processing mechanism . Another interesting approach was demonstrated by Han et al: PLGA NPs coated with a polycation (protamine) enhanced their adjuvant ability, resulting in a strong antibody response to the encapsulated antigen, as a result of the increased cross‐presentation of encapsulated exogenous antigen .…”

Section: Cancer Immunotherapymentioning

confidence: 99%

Immunostimulation and Immunosuppression: Nanotechnology on the Brink

et al. 2018

View full text Add to dashboard Cite

Immunotherapy is revolutionizing current therapies in cancer and in autoimmune diseases, showing impressive results in clinical trials. Recently, the development of innovative nano‐biomaterials has been focusing on the interactions between such materials and the immune system, both in the adaptive and innate branches. Biomaterials can display immunostimulative, neutral, or immunosuppressive interactions. Nanoparticles displaying immunostimulative potential are employed in the formulation of cancer vaccines, while immunosuppressive materials are being researched for the development of vaccines able to induce tolerance in autoimmune diseases. Here, the properties influencing the immunomodulation effect of nanomaterials are analyzed, followed by a detailed review of the recent applications of nanomaterials for the delivery of antigens, adjuvants, chemotherapeutics, and immunomodulatory drugs.

show abstract

Cationic micelle delivery of Trp2 peptide for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses

Cited by 88 publications

References 39 publications

Induction of HIV-1 gag specific immune responses by cationic micelles mediated delivery of gag mRNA

Induction of HIV-1 gag specific immune responses by cationic micelles mediated delivery of gag mRNA

Modulating the immune system through nanotechnology

Immunostimulation and Immunosuppression: Nanotechnology on the Brink

Contact Info

Product

Resources

About