Cationic antimicrobial copolymer poly (methylmethacrylate‐co‐PHMG) decontaminates water

Aviv, Oren; Ratner, S. B.; Amir, Nir; Laout, Natalia; Basu, Arijit; Shadmon, Hodaya; Beyth, Nurit; Domb, Abraham J.

doi:10.1002/pat.3770

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…We explain this by the fact that TBD catalyst is covalently connected to the network during the polymerization. It is well-known that -NH- groups of TBD can react with epoxy, in addition, the strong basicity of the guanidine group is not only helpful to the opening of epoxy groups, but also can act with acid 48 , 49 .…”

Section: Resultsmentioning

confidence: 99%

Solvent-assisted programming of flat polymer sheets into reconfigurable and self-healing 3D structures

et al. 2018

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It is extremely challenging, yet critically desirable to convert 2D plastic films into 3D structures without any assisting equipment. Taking the advantage of solvent-induced bond-exchange reaction and elastic-plastic transition, shape programming of flat vitrimer polymer sheets offers a new way to obtain 3D structures or topologies, which are hard for traditional molding to achieve. Here we show that such programming can be achieved with a pipette, a hair dryer, and a bottle of solvent. The polymer used here is very similar to the commercial epoxy, except that a small percentage of a specific catalyst is involved to facilitate the bond-exchange reaction. The programmed 3D structures can later be erased, reprogrammed, welded with others, and healed again and again, using the same solvent-assisted technique. The 3D structures can also be recycled by hot-pressing into new sheets, which can still be repeatedly programmed.

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Section: Resultsmentioning

confidence: 99%

Solvent-assisted programming of flat polymer sheets into reconfigurable and self-healing 3D structures

et al. 2018

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“…The derivatives of guanidine monomers such as polyhexamethylene guanidine (PHMG) and polyhexamethylene biguanidine (PHMB) are applied in interfacial polymerisation reactions with trimesoyl chloride (TMC) on the polysulfone surface, which leads to the formation of ultrafiltration membranes, exhibiting antibacterial activity against S. aureus and E. coli [ 39 ]. Copolymers MMA and PHMG—i.e., poly(MMA-co-PHMG)—are efficient in fighting tap water E. coli and heterotrophic-plate-count bacteria [ 40 ]. Besides the abovementioned synthetic polymers containing nitrogen atoms, the linear quaternary ammonium polymers (QACs) constitute an important group of antibacterial compounds.…”

Section: Methods Of Obtaining Polymers With Antibacterial Propertiesmentioning

confidence: 99%

Preparation and Functionalization of Polymers with Antibacterial Properties—Review of the Recent Developments

Parcheta

Sobiesiak

2023

Materials

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The presence of antibiotic-resistant bacteria in our environment is a matter of growing concern. Consumption of contaminated drinking water or contaminated fruit or vegetables can provoke ailments and even diseases, mainly in the digestive system. In this work, we present the latest data on the ability to remove bacteria from potable water and wastewater. The article discusses the mechanisms of the antibacterial activity of polymers, consisting of the electrostatic interaction between bacterial cells and the surface of natural and synthetic polymers functionalized with metal cations (polydopamine modified with silver nanoparticles, starch modified with quaternary ammonium or halogenated benzene). The synergistic effect of polymers (N-alkylaminated chitosan, silver doped polyoxometalate, modified poly(aspartic acid)) with antibiotics has also been described, allowing for precise targeting of drugs to infected cells as a preventive measure against the excessive spread of antibiotics, leading to drug resistance among bacteria. Cationic polymers, polymers obtained from essential oils (EOs), or natural polymers modified with organic acids are promising materials in the removal of harmful bacteria. Antimicrobial polymers are successfully used as biocides due to their acceptable toxicity, low production costs, chemical stability, and high adsorption capacity thanks to multi-point attachment to microorganisms. New achievements in the field of polymer surface modification in order to impart antimicrobial properties were summarized.

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“…[18][19][20] Especially, polyhexamethylguanidine (PHMG) has been recognized as a kind of macromolecular antibacterial agent with broad spectrum sterilization effect, high stability, and low-cost. [21] Obviously, PHMG and its derivatives have been widely applied in various fields, such as food processing [22] and transportation, [23] farm disinfection, [24] sewage purification, [25] and so on. The cationic groups of PHMG could adsorb to the surface of bacteria, so as to inhibit the division function of bacteria and viruses, so that bacteria and viruses lose reproductive ability.…”

Section: Introductionmentioning

confidence: 99%

Anchoring Guanidine Polymer onto Sesbania Gum to Endow Excellent Antibacterial Function

Lan

Chu

et al. 2023

Macro Chemistry & Physics

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Infectious diseases caused by pathogenic bacteria invasion have become a serious threat to human life and health. In this study, polyhexamethylguanidine (PHMG) is anchored onto sesbania gum (SG) by an oxidation reaction coupled with the Schiff base reaction to endow antibacterial function. By the assistance of the oxidation reaction using sodium periodate (NaIO 4 ) as an oxidizing agent, the oxidized SG (OSG) forms and contributes to the generation of a platform with active sites for further antibacterial modification with PHMG. Then PHMG as antibacterial ingredient covalently bind on OSG, which helps to achieve SG-PHMG. After the colony counting method and inhibition zone test, SG-PHMG shows excellent antibacterial ability against 10 8 CFU mL −1 of Escherichia coli (E. coli). More interestingly, the grafting of PHMG makes SG more hydrophilic, and allows SG-PHMG fully contact with bacteria, as a result showing excellent antibacterial activity. It is believed that this strategy has great potential for the antibacterial-associated applications.

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Cationic antimicrobial copolymer poly (methylmethacrylate‐co‐PHMG) decontaminates water

Cited by 8 publications

References 15 publications

Solvent-assisted programming of flat polymer sheets into reconfigurable and self-healing 3D structures

Solvent-assisted programming of flat polymer sheets into reconfigurable and self-healing 3D structures

Preparation and Functionalization of Polymers with Antibacterial Properties—Review of the Recent Developments

Anchoring Guanidine Polymer onto Sesbania Gum to Endow Excellent Antibacterial Function

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