Catheter-related infections in patients with haematological malignancies: novel preventive and therapeutic strategies

Zakhour, Ramia; Chaftari, Anne-Marie; Raad, Issam

doi:10.1016/s1473-3099(16)30213-4

Cited by 78 publications

(59 citation statements)

References 91 publications

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“…Although CoNS are a part of the normal flora of human skin and mucosa, they can cause serious infections, especially in immunocompromised individuals and neonates. In cases of hospital-acquired bloodstream infections, CoNS account for the largest number of cases (3,4). Out of the CoNS pathogens, Staphylococcus epidermidis is the most commonly isolated causative agent in CRBSI (5), and Staphylococcus haemolyticus is the second most common species isolated from human blood cultures (5,6).…”

mentioning

confidence: 99%

Efficient Killing of Planktonic and Biofilm-Embedded Coagulase-Negative Staphylococci by Bactericidal Protein P128

Poonacha¹,

Nair²,

Desai³

et al. 2017

Antimicrob Agents Chemother

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Coagulase-negative staphylococci (CoNS) are the major causative agents of foreign-body-related infections, including catheter-related bloodstream infections. Because of the involvement of biofilms, foreign-body-related infections are difficult to treat. P128, a chimeric recombinant phage-derived ectolysin, has been shown to possess bactericidal activity on strains of Staphylococcus aureus, including methicillinresistant S. aureus (MRSA). We tested the killing potential of P128 on three clinically significant species of CoNS, S. epidermidis, S. haemolyticus, and S. lugdunensis, under a variety of physiological conditions representing growing and nongrowing states. The MIC 90 and minimum bactericidal concentration at which 90% of strains tested are killed (MBC 90 ) of P128 on 62 clinical strains of CoNS were found to be 16 and 32 g/ml (0.58 and 1.16 M), respectively, demonstrating the bactericidal nature of P128 on CoNS strains. Serum showed a potentiating effect on P128 inhibition, as indicated by 4-to 32-fold lower MIC values observed in serum. P128 caused a rapid loss of viability in all CoNS strains tested. Persisters of CoNS that were enriched in the presence of vancomycin or daptomycin were killed by P128 at 1ϫ the MIC in a rapid manner. Low concentrations of P128 caused a 2-to 5-log reduction in CFU in stationary-phase or poorly metabolizing CoNS cultures. P128 at low concentrations eliminated CoNS biofilms in microtiter plates and on the surface of catheters. Combinations of P128 and standard-of-care (SoC) antibiotics were highly synergistic in inhibiting growth in preformed biofilms. Potent activity on planktonic cells, persisters, and biofilms of CoNS suggests that P128 is a promising candidate for the clinical development of treatments for foreign-body-related and other CoNS infections.

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mentioning

confidence: 99%

Efficient Killing of Planktonic and Biofilm-Embedded Coagulase-Negative Staphylococci by Bactericidal Protein P128

Poonacha¹,

Nair²,

Desai³

et al. 2017

Antimicrob Agents Chemother

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“…Catheters impregnated with M/R have been previously shown to confer antimicrobial activity in vascular catheters, such as CVCs and peripherally inserted central catheters (PICCs) (8)(9)(10)(11)(12). While CHD alone has not been assessed compared to M/R or M/R plus CHD, M/R-plus-CHD CVCs and PICCs have demonstrated superior inhibition of biofilm colonization in previous in vitro studies compared with chlorhexidine plus silver sulfadiazine (CHD/SS) and M/R catheters (13,19).…”

Section: Discussionmentioning

confidence: 99%

“…Biofilms formed on implanted foreign-body surfaces, such as PCN catheters, can be especially recalcitrant to systemic antibiotic treatments, since many antibiotics are unable to penetrate the protective exopolysaccharide matrix formed by microbial biofilms on plastic surfaces (7). Minocycline-rifampin (M/R)-impregnated central venous catheters (CVCs) have demonstrated reduction in catheter-related bloodstream infections for patients with indwelling CVCs for vascular access (8)(9)(10)(11)(12). Further, CVCs coated with M/R and chlorhexidine (CHD) have demonstrated enhanced effectiveness in vitro in completely preventing biofilm colonization of vascular catheters by resistant bacteria and fungal organisms (13,14).…”

mentioning

confidence: 99%

In Vitro Study of Antimicrobial Percutaneous Nephrostomy Catheters for Prevention of Renal Infections

Vargas-Cruz

Reitzel

Rosenblatt

et al. 2017

Antimicrob Agents Chemother

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Percutaneous nephrostomy (PCN) catheters are the primary method for draining ureters obstructed by malignancy and preventing a decline of renal function. However, PCN catheter-related infections, such as pyelonephritis and urosepsis, remain a significant concern. Currently, no antimicrobial PCN catheters are available for preventing infection complications. Vascular catheters impregnated with minocyclinerifampin (M/R) and M/R with chlorhexidine coating (M/R plus CHD) have previously demonstrated antimicrobial activity. Therefore, in this study, we examined whether these combinations could be applied to PCN catheters and effectively inhibit biofilm formation by common uropathogens. An in vitro biofilm colonization model was used to assess the antimicrobial efficacy of M/R and M/R-plus-CHD PCN catheters against nine common multidrug-resistant Gram-positive and Gram-negative uropathogens as well as Candida glabrata and Candida albicans. Experimental catheters were also assessed for durability of antimicrobial activity for up 3 weeks. PCN catheters coated with M/R plus CHD completely inhibited biofilm formation for up to 3 weeks for all the organisms tested. The reduction in colonization compared to uncoated PCN catheters was significant for all Gram-positive, Gram-negative, and fungal organisms (P Ͻ 0.05). M/R-plus-CHD PCN catheters also produced significant reductions in biofilm colonization relative to M/R PCN catheters for Enterobacter spp., Escherichia coli, Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, C. glabrata, and C. albicans (P Ͻ 0.05). M/R-plus-CHD PCN catheters proved to be highly efficacious in preventing biofilm colonization when exposed to multidrug-resistant pathogens common in PCN catheterassociated pyelonephritis. M/R-plus-CHD PCN catheters warrant evaluation in a clinical setting to assess their ability to prevent clinically relevant nephrostomy infections.

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“…Bu durum hastaları fırsatçı patojenlerinde kolaylıkla eklendiği enfeksiyoz tablolara açık hâle getirmektedir. Port kateterlerinin immünsuprese hastalarda, periferik venöz ve santral kataterlere göre daha düşük infeksiyon riski taşıdıkları literatürde gösterilmiştir [12,13] . Özer ve ark.…”

Section: Discussionunclassified

Vascular Port: Retrospective Evaluation

Akdemir¹,

Şahin²,

Aksoy³

et al. 2017

GKDA Derg

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ÖZ Amaç: Malignite tanısı alan hastalarda yineleyen intravenöz (IV) yollara ulaşımın zorluğu sık karşılaşılan bir sorundur. Çalışmamızın amacı, kemoterapi uygulanacak hastalardaki port kateter yerleştirme işlemleri-mizi retrospektif olarak değerlendirmektir. Gereç ve GiRiŞİmplante edilebilir port kateterlerinin tercih edilmesi birçok avantaj sağlamaktadır. Düşük infeksiyon riski, vücut yüzeyinde hastayı rahatsız eden bölüm-lerinin olmaması ve hastanın fiziksel aktivitesini kı-sıtlamaması bu avantajlar arasında sayılabilir. Kanser hastalarında özellikle uzun dönem kemoterapi uygu-

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Catheter-related infections in patients with haematological malignancies: novel preventive and therapeutic strategies

Cited by 78 publications

References 91 publications

Efficient Killing of Planktonic and Biofilm-Embedded Coagulase-Negative Staphylococci by Bactericidal Protein P128

Efficient Killing of Planktonic and Biofilm-Embedded Coagulase-Negative Staphylococci by Bactericidal Protein P128

In Vitro Study of Antimicrobial Percutaneous Nephrostomy Catheters for Prevention of Renal Infections

Vascular Port: Retrospective Evaluation

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