1977
DOI: 10.1161/01.str.8.3.341
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Abstract: The incidence of ischemia induced by carotid occlusion decreased from 44% to 26% in PCPA-treated animals, which also suggests that depletion of 5-HT available for neuronal release prior to the induction of ischemia may reduce stroke incidence by limiting impairment of collateral vasocapacitance. PCPA pretreatment did not influence the development of edema in the occluded hemisphere of ischemic animals once ischemia was established.

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Cited by 78 publications
(34 citation statements)
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References 22 publications
(21 reference statements)
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“…Serotonin has been reported to progressively decrease only in the occluded hemisphere of ischemic animals, and preischemic depletion of brain serotonin with p-chlorophenylalanine has been reported to decrease the incidence of ischemia (Welch et al, 1977). The improvement of photothrombotic cortical ischemia with fluoxetine and sertraline is also in accordance with the results of previous studies that have emphasized on serotonergic dysfunction as an etiology of aggression in patients with depression (Van Praag, 1998) or stroke (Kim et al, 2002).…”
Section: Discussionsupporting
confidence: 80%
“…Serotonin has been reported to progressively decrease only in the occluded hemisphere of ischemic animals, and preischemic depletion of brain serotonin with p-chlorophenylalanine has been reported to decrease the incidence of ischemia (Welch et al, 1977). The improvement of photothrombotic cortical ischemia with fluoxetine and sertraline is also in accordance with the results of previous studies that have emphasized on serotonergic dysfunction as an etiology of aggression in patients with depression (Van Praag, 1998) or stroke (Kim et al, 2002).…”
Section: Discussionsupporting
confidence: 80%
“…Conversely, Wein berger et al reported that alpha -methyl para tyrosine treatment protected against dopa mine, serotonin and glutamate terminal damage induced by cerebral ischemia (11). Welch et al found that p-chlorophenyl alanine treatment decreased the incidence of ischemia induced by unilateral carotid arteries occlusion (12). While there are inconsisten cies in all these data, nevertheless, the results suggest that monoamine neurotransmitters have an important role in the neuronal death induced by cerebral ischemia.…”
mentioning
confidence: 97%
“…In view of the interest in the possible effects of vasoactive substances released during an ischemic stroke 6 "' we believe our negative findings are of interest.…”
Section: Discussionmentioning
confidence: 80%
“…3 ' 4 Preliminary studies suggested little or no effect of ligation on the contractile response to norepinephrine (NOR) but an enhancing effect on the response to BaClj. 6 We have since completed a further study of this problem.…”
mentioning
confidence: 99%