Catenation and encapsulation induce distinct reconstitutions within a dynamic library of mixed-ligand Zn₄L₆ cages

Abstract

Subcomponent self-assembly generates dynamic combinatorial libraries of Zn4L6 cages whose composition is strongly affected by catenation and encapsulation.

Quantified structural speciation in self-sorted CoII6L4 cage systems

“… 18 Modulating the binding strength of the templating guest can reorganise product mixtures to express specific products. 19 A template can also generate a set of well-defined structures, instead of a single product. 20 …”

“…We envisage applicability in the areas of asymmetric catalysis 6h , 25 and guest-specific receptor design. 19 , 26 …”

Integrative self-sorting of coordination cages based on ‘naked’ metal ions

“…Nitschke and co-workers reported the synthesis and self-sorting of two related tetrahedral cages, [Zn 4 1 6 ] 8+ and [Zn 4 17 6 ] 8+ , prepared by sub-component self-assembly of Zn II and NDI ( S1 ) or porphyrin-derived ( S17 ) subunits. 65 A study of the host–guest properties revealed that each cage can respond to a different stimulus; the electron-poor NDI units of [Zn 4 1 6 ] 8+ were found to thread up to two electron-rich crown-ether macrocycles, while [Zn 4 17 6 ] 8+ was found to accommodate a C 70 guest in its cavity ( Fig. 12a and b ).…”

Ion‐Mobility Mass Spectrometry for the Rapid Determination of the Topology of Interlocked and Knotted Molecules

“…[10,11] These analytical limitations become even more severe when the knotted or catenated structures are formed in complex mixtures of (quickly) interconverting dynamic combinatorial libraries, [12] in which multiple species coexist. [13] Ac hange of conditions,f or example,t emperature, pH, concentration, or solvent, may then lead to shifts of the equilibrium to other topologies. [2] Fore xample,P rakasam et al [14] observed at ransformation of at refoil knot into aH opf link, when the temperature was raised.…”