Catechol-functionalized hydrogels: biomimetic design, adhesion mechanism, and biomedical applications

Zhang, Wei; Wang, Ruixing; Sun, ZhengMing; Zhu, Xiangwei; Zhen, Qiang; Zhang, Tengfei; Cholewinski, Aleksander; Yang, Fut K.; Zhao, Boxin; Pinnaratip, Rattapol; Forooshani, Pegah Kord; Lee, Bruce P.

doi:10.1039/c9cs00285e

Cited by 599 publications

(532 citation statements)

References 249 publications

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“…At the same time, the hydrogel preparation method is simple and easy to operate during the preparation process, and has long-term stability, which greatly expands the application of hydrogels in underwater or humid environments, especially in the potential of body fluids or blood environments [ 95 ]. Zhang et al [ 96 ] summarized the technical difficulties in the underwater adhesion of hydrogel materials, focused on the relevant parameters that characterize the underwater mechanical properties of hydrogels, and established the experimental design and evaluation methods for hydrogel materials based on this, and summarized the unique properties, synthesis method, and preparation process of the biomimetic viscous hydrogel, and proposed new insights into the underwater adhesion mechanism.…”

Section: Resultsmentioning

confidence: 99%

Applications of Hydrogel with Special Physical Properties in Bone and Cartilage Regeneration

Lin

Yin

et al. 2021

Materials

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Hydrogel is a polymer matrix containing a large amount of water. It is similar to extracellular matrix components. It comes into contact with blood, body fluids, and human tissues without affecting the metabolism of organisms. It can be applied to bone and cartilage tissues. This article introduces the high-strength polymer hydrogel and its modification methods to adapt to the field of bone and cartilage tissue engineering. From the perspective of the mechanical properties of hydrogels, the mechanical strength of hydrogels has experienced from the weak-strength traditional hydrogels to the high-strength hydrogels, then the injectable hydrogels were invented and realized the purpose of good fluidity before the use of hydrogels and high strength in the later period. In addition, specific methods to give special physical properties to the hydrogel used in the field of bone and cartilage tissue engineering will also be discussed, such as 3D printing, integrated repair of bone and cartilage tissue, bone vascularization, and osteogenesis hydrogels that regulate cell growth, antibacterial properties, and repeatable viscosity in humid environments. Finally, we explain the main reasons and contradictions in current applications, look forward to the research prospects in the field of bone and cartilage tissue engineering, and emphasize the importance of conducting research in this field to promote medical progress.

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Section: Resultsmentioning

confidence: 99%

Applications of Hydrogel with Special Physical Properties in Bone and Cartilage Regeneration

Lin

Yin

et al. 2021

Materials

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“…As the promising drug carriers, hydrogels have been experiencing fast development in recent years (Lai and He, 2016 ; Oliva et al, 2017 ). With the retained large amounts of water and excellent biocompatibility, hydrogels demonstrated useful tool for targeted drug delivery and controlled drug release (Li and Mooney, 2016 ; Lei et al, 2018 ; Huang et al, 2020 ; Zhang et al, 2020a ). According to the cross-linking methods, hydrogels can be formed through non-covalent physical interactions or covalent chemical bonds (Goujon et al, 2017 ; Gu et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Dynamic Hydrogels Based on Double Imine Connections and Application for Delivery of Fluorouracil

Zhang

Pham

et al. 2020

Front. Chem.

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Dynamic hydrogels have been prepared by cross-linking of O -carboxymethyl chitosan ( O -CMCS) with reversibly connected imino-PEGylated dynamers. The double imine chitosan/dynamer and dynamer bonds and were used to provide tighter structures and adaptive drug release behaviors of the hydrogels. The structural and physical properties of the resulted hydrogels were examined, showing good thermal stability and higher swelling behaviors (up to 3,000%). When hydrogels with various composition ratios were further applied for delivery of anti-cancer drug fluorouracil (5-FU), high drug encapsulation rates were recorded, up to 97%. The release profile of 5-FU showed fast rate at the beginning, followed by slow increase to the maximum amount within 12 h, demonstrating potential as drug carriers for efficient drug delivery.

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“…This initiates a polymerization reaction, which makes catecholfunctionalized polymers suitable for oxidation-mediated hydrogel crosslinking. [94] Seminal work from Lee et al showed the gelation of dopamine-functionalized, multiarm PEG upon the addition of an oxidizing agent, sodium periodate. [95] Similarly, the addition of sodium periodate was able to induce the gelation of catechol-terminated poly(p-phenylene oxide)/ PEG, [96] gelatin, [97] recombinant fp-1 mussel adhesive protein, [98] and HA.…”

Section: Change In Oxidation Statementioning

confidence: 99%

Tailoring Gelation Mechanisms for Advanced Hydrogel Applications

Nele

Wojciechowski

Armstrong

et al. 2020

Adv Funct Materials

191

100

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Hydrogels are one of the most commonly explored classes of biomaterials. Their chemical and structural versatility has enabled their use across a wide range of applications, including tissue engineering, drug delivery, and cell culture. Hydrogels form upon a sol-gel transition, which can be elicited by different triggers designed to enable precise control over hydrogelation kinetics and hydrogel structure. The chosen hydrogelation trigger and chemistry can have a profound effect on the success of the targeted application. In this Progress Report, a critical overview of recent advances in hydrogel design is presented, with a focus on the available strategies used to trigger the formation of hydrogel networks (e.g., temperature, light, ultrasound). These triggers are presented within a new classification system, and their suitability for six key hydrogel-based applications is assessed. This Progress Report is intended to guide trigger selection for new hydrogel applications and inspire the rational design of new hydrogelation trigger mechanisms.

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Catechol-functionalized hydrogels: biomimetic design, adhesion mechanism, and biomedical applications

Abstract: This review presents insights into the fundamental challenges of wet adhesion, and the applications of catechol-functionalized hydrogels in diverse areas.

Cited by 599 publications

References 249 publications

Applications of Hydrogel with Special Physical Properties in Bone and Cartilage Regeneration

Applications of Hydrogel with Special Physical Properties in Bone and Cartilage Regeneration

Dynamic Hydrogels Based on Double Imine Connections and Application for Delivery of Fluorouracil

Tailoring Gelation Mechanisms for Advanced Hydrogel Applications

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