Catechin and caffeine content of tea (Camellia sinensis L.) leaf significantly differ with seasonal variation: A study on popular cultivars in North East India

Deka, Himangshu; Barman, T.S.; Dutta, Jintu; Devi, Arundhuti; Tamuly, Pradip; Paul, Ranjit Kumar; Karak, Tanmoy

doi:10.1016/j.jfca.2020.103684

Cited by 28 publications

(31 citation statements)

References 40 publications

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“…26 Tocklai Tea Research Institute (TTRI), India has developed 35 vegetative propagated tea cultivars and these cultivars are being extensively used by the tea industry in NE India as planting material for black tea production. 4 The biochemical characterization of young fresh leaves of these cultivars coupled with their variation with the season had been reported in earlier studies. 4,29 However, reports on black tea processing from the young leaves of these cultivars are very scanty.…”

Section: Introductionmentioning

confidence: 80%

“…4 The biochemical characterization of young fresh leaves of these cultivars coupled with their variation with the season had been reported in earlier studies. 4,29 However, reports on black tea processing from the young leaves of these cultivars are very scanty. Therefore, to enlighten the black tea processing from the biochemical aspect, this investigation aims to determine the changes in catechin, caffeine, and total polyphenol (TP) content with the formation of theaavins, and the variation of antioxidant activity at different stages of black tea processing.…”

Section: Introductionmentioning

confidence: 80%

“…The meteorological data of the estate during 2017 and the origin of the cultivars can be obtained from our recent work. 4 Black tea processing and sample preparation The CTC black tea was processed using the environmentcontrolled manufacturing (ECM) unit obtained from Teacra, United Kingdom. For the rst step of CTC black tea processing i.e.…”

Section: Tea Leaf Samplingmentioning

confidence: 99%

“…affect the content of non-volatile compounds in young shoots used for tea processing. 4,5 Compounds contributing to the quality of tea infusion vary between harvest period and cultivar. 4,6 Catechins, the major quality phenolic compounds in tea, represent 10 to 25% of fresh leaf dry weight.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 Compounds contributing to the quality of tea infusion vary between harvest period and cultivar. 4,6 Catechins, the major quality phenolic compounds in tea, represent 10 to 25% of fresh leaf dry weight. 7,8 The principal catechins contributing 50 to 80% to total catechin (TC) are (+)-catechin, (À)-epigallocatechin (EGC), (À)-epicatechin (EC), (À)-epigallocatechin gallate (EGCG) and (À)-epicatechin gallate (ECG) 9,10 (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Changes in major catechins, caffeine, and antioxidant activity during CTC processing of black tea from North East India

et al. 2021

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Section: Introductionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 80%

Section: Tea Leaf Samplingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Changes in major catechins, caffeine, and antioxidant activity during CTC processing of black tea from North East India

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Combination of HPLC–orbitrap‐MS/MS and network pharmacology to identify the anti‐inflammatory phytochemicals in the coffee leaf extracts

Mei

Chen

2023

Food Frontiers

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In this study, we investigated the phytochemical compositions and the associated anti‐inflammatory activity of coffee leaf fractions prepared by sequential solvent extraction using high‐performance liquid chromatography–orbitrap‐tandem mass spectrometry (HPLC–orbitrap‐MS/MS) combined with network pharmacology. The results showed that the ethyl acetate fraction (EAC‐L) had the highest nitric oxide (NO), ABTS, and DPPH free radical scavenging abilities due to the higher concentrations of mangiferin, rutin, 3,5‐dicaffeoylquinic acid (3,5‐diCQA), and 4,5‐diCQA. The extraction solvents had the greatest impact on the anti‐inflammatory activity of coffee leaf fractions, whereas the processing method had the most significant effect on the antioxidant activity of these fractions. Untargeted metabolomics analysis using HPLC–orbitrap‐MS/MS indicated that palmitic acid, 3,4‐dihydroxybenzaldehyde, and caffeic acid may be involved in the anti‐inflammatory activity of EAC‐L fraction obtained from fresh coffee leaves. On the other hand, processed coffee leaf fraction exhibited anti‐inflammatory activity that was attributed to the presence of 9S,13R‐12‐oxophytodienoic acid, pinocembrin, and quercetin, which have high degree values associated with the inflammation network. Gene ontology and Kyoto encyclopedia of genes and genomes enrichment of network pharmacology analysis showed that these 35 differential compounds in the coffee leaf fractions affect cell transcription, apoptosis, phosphorylation, NO synthesis, phosphatidylinositide 3‐kinases‐protein kinase B (PI3K‐Akt) signaling pathway, focal adhesion, hypoxia‐inducible factor‐1, hepatitis, cancer, and so on. This result indicated that coffee leaf extract may also function as an inhibitor for inflammation‐related cancers. The findings of our research are valuable in guiding the extraction of anti‐inflammatory components from coffee leaves.

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Evaluation of tea (Camellia sinensis L.) phytochemicals as multi-disease modulators, a multidimensional in silico strategy with the combinations of network pharmacology, pharmacophore analysis, statistics and molecular docking

Nag

2022

Mol Divers

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Tea ( Camellia sinensis L.) is considered as to be one of the most consumed beverages globally and a reservoir of phytochemicals with immense health benefits. Despite numerous advantages, tea compounds lack a robust multi-disease target study. In this work, we presented a unique in silico approach consisting of molecular docking, multivariate statistics, pharmacophore analysis, and network pharmacology approaches. Eight tea phytochemicals were identified through literature mining, namely gallic acid, catechin, epigallocatechin gallate, epicatechin, epicatechin gallate (ECG), quercetin, kaempferol, and ellagic acid, based on their richness in tea leaves. Further, exploration of databases revealed 30 target proteins related to the pharmacological properties of tea compounds and multiple associated diseases. Molecular docking experiment with eight tea compounds and all 30 proteins revealed that except gallic acid all other seven phytochemicals had potential inhibitory activities against these targets. The docking experiment was validated by comparing the binding affinities (Kcal mol −1 ) of the compounds with known drug molecules for the respective proteins. Further, with the aid of the application of statistical tools (principal component analysis and clustering), we identified two major clusters of phytochemicals based on their chemical properties and docking scores (Kcal mol −1 ). Pharmacophore analysis of these clusters revealed the functional descriptors of phytochemicals, related to the ligand–protein docking interactions. Tripartite network was constructed based on the docking scores, and it consisted of seven tea phytochemicals (gallic acid was excluded) targeting five proteins and ten associated diseases. Epicatechin gallate (ECG)-hepatocyte growth factor receptor (PDB id 1FYR) complex was found to be highest in docking performance (10 kcal mol −1 ). Finally, molecular dynamic simulation showed that ECG-1FYR could make a stable complex in the near-native physiological condition. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s11030-022-10437-1.

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Catechin and caffeine content of tea (Camellia sinensis L.) leaf significantly differ with seasonal variation: A study on popular cultivars in North East India

Cited by 28 publications

References 40 publications

Changes in major catechins, caffeine, and antioxidant activity during CTC processing of black tea from North East India

Changes in major catechins, caffeine, and antioxidant activity during CTC processing of black tea from North East India

Combination of HPLC–orbitrap‐MS/MS and network pharmacology to identify the anti‐inflammatory phytochemicals in the coffee leaf extracts

Evaluation of tea (Camellia sinensis L.) phytochemicals as multi-disease modulators, a multidimensional in silico strategy with the combinations of network pharmacology, pharmacophore analysis, statistics and molecular docking

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