Catalytic rhodium (Rh)-based (mesoporous polydopamine) MPDA nanoparticles with enhanced phototherapeutic efficiency for overcoming tumor hypoxia

Abstract

<p>Rh NPs/Ce6 loaded mesoporous polydopamine (Ce6-Rh@MPDA) nanoparticles were developed to achieve photoacoustic/fluorescence imaging-guided photothermal and photodynamic therapy to eliminate tumors and improve hypoxia in tumor microenvironments.</p>

Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics

“…MPDA nanoformulations are also used to overcome multidrug resistance [ 142 ], intratumoral hypoxia [ 143 ], and the fluorescence quenching characteristics of drugs [ 144 ]. At present, a MPDA nanotherapy system is combined with hyperthermia therapy, chemotherapy, and multimodal imaging-guided therapy to control drug resistance in tumor cells.…”

Intervention of Polydopamine Assembly and Adhesion on Nanoscale Interfaces: State‐of‐the‐Art Designs and Biomedical Applications

“…Chlorin e6 (Ce6) was chosen as another favorable photosensitizer by virtue of its high efficiency of singlet oxygen ( 1 O 2 ) generation and good fluorescence imaging capacity in tumor phototherapy. [ 179 ] For example, a catalytic nanosystem (Ce6‐Rh@MPDA) was developed using MPDA to encapsulate catalase‐like rhodium (Rh) nanoparticles and photosensitizer Ce6 for photoacoustic/fluorescence dual imaging‐guided tumor therapy by Ding et al [ 180 ] Typically, Ce6‐Rh@MPDA could catalyze the in situ oxygen (O 2 ) production from tumor‐enriched H 2 O 2 to improve PDT efficiency, while the mesoporous structure of MPDA played a significant role via providing sufficient contact between catalytic active sites and reactants. In another similar work, Hu and coworkers demonstrated a multi‐functional nanoplatform based on MPDA‐loaded Pt/Ce6/DOX for PDT/PTT/chemotherapy.…”

Local delivery to malignant brain tumors: potential biomaterial-based therapeutic/adjuvant strategies

“…122 Catalase is a hemoprotein enzyme that is found in most cells and decomposes H 2 O 2 to oxygen and water. 111 It has therefore often been used with oxygen-generating biomaterials through conjugation with the carrier, 123 embedding within the carrier, 60,116 or being added to the surrounding medium, 125 though in principle, other catalytic agents such as potassium iodide, 126 platinum, 116,127,128 palladium, 128 rhodium, 129 hemin 130 and manganese dioxide 131 could also be utilized.…”