Cat-scratch disease. Histopathologic changes in the skin

Johnson, W. T.

doi:10.1001/archderm.100.2.148

Cited by 14 publications

(6 citation statements)

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“…Although biopsy confirmation of CSD has been rarely required (especially in lieu of a reliable serologic test-see below), a constant pathologic hallmark of CSD-affected tissues has been granuloma formation. With hematoxylin and eosin stains, the primary inoculation lesion of CSD reveals small areas of frank necrosis surrounded by concentric layers of histiocytes, lymphocytes, and nucleated giant cells (9). Affected lymph nodes are characterized by necrotizing granulomas ringed by lymphocytic infiltrates and multinucleated giant cells.…”

Section: Clinical Features Of Csdmentioning

confidence: 99%

Unraveling Mysteries Associated with Cat-Scratch Disease, Bacillary Angiomatosis, and Related Syndromes

Regnery¹,

Tappero²

1995

Emerg. Infect. Dis.

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The search for the infectious agents responsible for cat-scratch disease, bacillary angiomatosis, and related syndromes has a long and often circuitous history. Recognition of the etiologic agents and a new understanding of the fundamental features of the epidemiology and natural history of modern day Bartonella (formerly Rochalimaea)-associated diseases culminate a multipartite story that combines clinical medicine, traditional microbiology, and novel technological approaches to solve a long-standing enigma.

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Section: Clinical Features Of Csdmentioning

confidence: 99%

Unraveling Mysteries Associated with Cat-Scratch Disease, Bacillary Angiomatosis, and Related Syndromes

Regnery¹,

Tappero²

1995

Emerg. Infect. Dis.

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“…Despite the unknown etiology, a clinical diagnosis of CSD was based on the presence of three of four criteria: (a) history of animal (usually cat) contact, with the presence of a scratch or an inoculation lesion of the skin, eye, or mucous membrane (14); (b) a positive CSD skin test; (c) regional lymphadenopathy with normal laboratory results for other causes of lymphadenopathy; and (d) characteristic histopathologic changes consistent with CSD in a biopsied lymph node (15), as described by Campbell (16). It should be noted that similar histopathologic changes may also be found in biopsies of inoculation lesions of the skin or conjunctiva (17), and sites of intradermal CSD skin test (17,18).…”

mentioning

confidence: 70%

“…Characteristic (but not pathognomonic) histopathologic changes consistent with CSD generally are noted in a biopsied lymph node (15,16) or inoculation lesion (15,17). Biopsy may be advised early when the index of suspicion is high but the skin test is negative for CSD (29).…”

Section: Diagnostic Workupmentioning

confidence: 99%

Cat–scratch Disease: A Review of the Literature

Shinall

1990

Pediatric Dermatology

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Cat-scratch disease (CSD) is a common cause of chronic lymphadenopathy (especially regional) that primarily affects children and adolescents. The clinical diagnosis of CSD is based on the presence of three of four criteria, which may include a positive CSD skin test. Usually a benign, self-limiting disease, CSD may sometimes have atypical manifestations and serious complications, particularly in immunocompromised hosts. Cat-scratch disease is now known to be caused by a small, gram-negative, pleomorphic bacterium. Antibiotics are dramatically effective against CSD in immunocompromised patients, but are not [corrected] of proven benefit in typical cases. Most patients recover with only symptomatic treatment. This article reviews the history of CSD research, clinical features of typical and atypical CSD, and current topics of interest in CSD research, especially in the areas of diagnosis and treatment.

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“…Biopsies of skin lesions also have received little attention. Johnson and Helwig (1969) reported that histopa thologic changes in the skin lesions in this disease were equivalent to those in the lymph nodes which consisted of a central acellular zone of necrosis surrounded by histiocytes, giant cells, and a mantle of lymphocytes. In the present review, there was one report in addition to the present one concerned with histology of the skin lesions.…”

Section: Discussionmentioning

confidence: 92%