Castleman disease mimicked pancreatic carcinoma: report of two cases

Abstract

Castleman disease (CD) is an uncommon benign lymphoproliferative disorder, which usually presents as solitary or multiple masses in the mediastinum. Peripancreatic CD was rarely reported. Herein, we report two cases of unicentric peripancreatic CD from our center. A 43-year-old man and a 58-year-old woman were detected to have a pancreatic mass in the routine medical examinations. Both of them were asymptomatic. The computed tomography and ultrasonographic examination revealed a mild enhancing solitary mass at the pancreatic head/neck. No definite preoperative diagnosis was established and Whipple operations were originally planned. The intraoperative frozen section diagnosis of both patients revealed lymphoproliferation. Then the local excisions of mass were performed. Histological examination revealed features of CD of hyaline-vascular type. No recurrence was found during the follow-up period. CD should be included in the differential diagnosis of pancreatic tumors. Local excision is a suitable surgical choice.

Retroperitoneal unicentric Castleman’s disease: A case report

“…Clinical manifestations of CD are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms [8]. The HV variety of CD is more common (90%) and is usually asymptomatic and presents as a localized disease [9], [10]. Abdominal and retroperitoneal locations may present with symptoms due to mass effect on adjacent organs as anorexia, weight loss, vomiting, urinary retention, and abdominal pain [11].…”

Unicentric Castleman’s Disease Masquerading Pancreatic Neoplasm

“…It remains usually asymptomatic [11, 12]. Abdominal and retroperitoneal locations may present with symptoms of mass effect on adjacent organs, for example, anorexia, weight loss, vomiting, urinary retention, and abdominal pain.…”

Castleman's disease presenting in the lungs: A report of two cases

“…CD has two clinical subtypes: Multicentric and unicentric (localized) (6). The unicentric variant of CD is the most common type and is localized to a single lymph node chain or area (5). In adults, 90% of localized CD cases are HV-type and predominantly occur in young adults (3).…”