Cassane Diterpenes from Caesalpinia bonduc

Cassane-type Diterpenes from the Seeds of Caesalpinia minax with Their Antineoplastic Activity

“…From the biological results, it can be concluded that the presence of an α,β-unsaturated γ-lactone in 1-3 and 6 may enhance the cytotoxic activity. It has previously been reported that some cassane diterpenes with structures similar to the ones of the compounds isolated in this study showed moderate cytotoxicity against several cancer cell lines [11].…”

“…Its seeds, known as "kushilian", have long been used in Chinese traditional medicine for treating anemopyretic colds, dysentery, itching of the skin and sores [3][4][5][6]. Recent studies indicate that the genus Caesalpinia is a rich source of cassane diterpenes and that most of the diterpenes display significant biological activities such as antimalarial [7], antibacterial [8], antihelmintic [9], antiproliferative and antineoplastic [10][11][12][13]. In order to find new antitumor agents from this plant, we examined the CHCl 3 extract of its seeds and isolated five new cassane-type diterpenes, named neocaesalpin AA (1), neocaesalpin AB (2), neocaesalpin AC (3), neocaesalpin AD (4) and neocaesalpin AE (5), together with three known diterpenes (6-8) (l " Fig.…”

In vitro biological activities of niloticane, a new bioactive cassane diterpene from the bark of Acacia nilotica subsp. kraussiana

“…1. Several cassane diterpenes have been isolated from plants belonging to the Fabaceae, especially from the genus Caesalpinia (Matsuno et al, 2009;Van Kiem et al, 2005;Yadav et al, 2009). The isolation of cassane diterpenoids from Acacia jacquemontii have been previously reported by Joshi et al (1979) and four new diterpene derivatives from the roots of Acacia farnesiana were also recently described by Lin et al (2009).…”

Chemical Constituents of Plants from the Genus Caesalpinia

“…Antiproliferative Activity. Compounds 97, 98, and 101 -103 were isolated from different parts of C. bonduc [25] [32]. Compounds 97 and 98 were found to inhibit MCF-7 breast cancer cell lines with IC 50 values of 12.8 and 6.1 mm, respectively, along with the inhibition of endometrial and cervical cancer cell lines.…”