Cashew Nut Shell Oil for Hyposensitization Against Rhus Dermatitis

Kligman, Albert M.

doi:10.1001/archderm.1958.01560090075016

Cited by 34 publications

(4 citation statements)

References 5 publications

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“…Severe systemic contact dermatitis has been described in rhus-sensitive patients who had ea ten cashew nuts [ 45]. This reaction was explained by an allergen in cashew nut shells, which cross-reacts with urishiol in poison ivy [46]. Systemic contact dermatitis has been seen in patients sensitive to balsam of Peru (Myroxylon Pereirae) which contains naturally occurring fiavours.…”

Section: Other Contact Allergensmentioning

confidence: 99%

Systemic Contact Dermatitis

Menné¹,

Veien²

2001

Textbook of Contact Dermatitis

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Section: Other Contact Allergensmentioning

confidence: 99%

Systemic Contact Dermatitis

Menné¹,

Veien²

2001

Textbook of Contact Dermatitis

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“…No exact numerical results are given. Cashew nut shell oil was tested as a possible cheap alternative to Rhus oleoresin [112] Epstein et al…”

Section: Clinical Trials Of Immunotherapy With Haptensmentioning

confidence: 99%

Immunotherapy of Allergic Contact Dermatitis

Śpiewak

2011

Immunotherapy

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The term 'immunotherapy' refers to treating diseases by inducing, enhancing or suppressing immune responses. As allergy is an excessive, detrimental immune reaction to otherwise harmless environmental substances, immunotherapy of allergic disease is aimed at the induction of tolerance toward sensitizing antigens. This article focuses on the historical developments, present state and future outlook for immunotherapy with haptens as a therapeutic modality for allergic contact dermatitis. Inspired by the effectiveness of immunotherapy in respiratory allergies, attempts were undertaken at curing allergic contact dermatitis by means of controlled administration of the sensitizing haptens. Animal and human experiments confirmed that tolerance to haptens can be induced most effectively when the induction of tolerance precedes attempted sensitization. In real life, however, therapy is sought by people who are already sensitized and an effective reversal of hypersensitivity seems more difficult to achieve. Decades of research on Rhus hypersensitivity led to a conclusion that immunotherapy can suppress Rhus dermatitis, however, only to a limited degree, for a short period of time, and at a high risk of side effects, which makes this method therapeutically unprofitable. Methodological problems with most available studies of immunotherapy of contact allergy to nickel make any definite conclusions impossible at this stage.

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“…After a note by R. Dakin in 1829, the first attempts in this direction were attributed to Schamberg in 1919 [385]. Other authors have then carried out oral or parenteral hyposensitization with varied results and sometimes severe side-effects, with reports of fatal renal complications [386][387][388]. Oral desensitization with daily intake of leaf extract in water has been reported as being beneficial on skin lesion and patch test results [389].…”

Section: Hyposensitizationmentioning

confidence: 99%