Case report: Subcutaneous metastasis from small cell carcinoma of the prostate

Kaplan, Mustafa; Atakan, İrfan Hüseyin; Bilgi, Selcuk; İnci, Osman

doi:10.1007/s11255-005-3620-8

Cited by 15 publications

(10 citation statements)

References 9 publications

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“…In addition, skin metastasis with NE differentiation is an extremely rare phenomenon. To date, only two cases of cutaneous metastasis from prostate adenocarcinoma showing NE differentiation have been reported …”

Section: Discussionmentioning

confidence: 99%

Cutaneous metastases from prostate cancer revealing neuroendocrine differentiation

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Cutaneous metastases from prostate cancer revealing neuroendocrine differentiation

et al. 2019

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“…208 Skin spread at other distant sites, such as neck 209 or eyelid, has also been reported. 210 The primary tumor is usually an adenocarcinoma, 2,211 but 1 case of transitional cell carcinoma, 212 a few cases of small cell carcinoma, 213,214 and a single case with signet-ring cells from mucinous prostatic adenocarcinoma 215 have been documented. Histopathologically, neoplastic deposits are usually in the dermis and consist of undifferentiated cells partially arranged in glands (small size, medium size, or cribriform) (Fig.…”

Section: Prostatic Carcinomasmentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

219

104

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Skin metastases occur in 0.6%-10.4% of all patients with cancer and represent 2% of all skin tumors. Skin metastases from visceral malignancies are important for dermatologists and dermatopathologists because of their variable clinical appearance and presentation, frequent delay and failure in their diagnosis, relative proportion of different internal malignancies metastasizing to the skin, and impact on morbidity, prognosis, and treatment. Another factor to take into account is that cutaneous metastasis may be the first sign of clinically silent visceral cancer. The relative frequencies of metastatic skin disease tend to correlate with the frequency of the different types of primary cancer in each sex. Thus, women with skin metastases have the following distribution in decreasing order of frequency of primary malignancies: breast, ovary, oral cavity, lung, and large intestine. In men, the distribution is as follows: lung, large intestine, oral cavity, kidney, breast, esophagus, pancreas, stomach, and liver. A wide morphologic spectrum of clinical appearances has been described in cutaneous metastases. This variable clinical morphology included nodules, papules, plaques, tumors, and ulcers. From a histopathologic point of view, there are 4 main morphologic patterns of cutaneous metastases involving the dermis, namely, nodular, infiltrative, diffuse, and intravascular. Generally, cutaneous metastases herald a poor prognosis. The average survival time of patients with skin metastases is a few months. In this article, we review the clinicopathologic and immunohistochemical characteristics of cutaneous metastases from internal malignancies, classify the most common cutaneous metastases, and identify studies that may assist in diagnosing the origin of a cutaneous metastasis.

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“…in 1977 [1]. Since then, several case reports have been published which together reached one consistent conclusion: poor survival [2–4].…”

Section: Introductionmentioning

confidence: 95%

Survival of patients with small cell carcinoma of the prostate during 1973–2003: a population‐based study

Deorah¹,

Rao²,

Raman³

et al. 2011

BJU International

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Study Type – Therapy (inception cohort) Level of Evidence 2a What's known on the subject? and What does the study add? Small cell carcinoma of the prostate is a lethal disease. Survival data is currently based on case reports and single institution case series which give limited information on its prognostic factors. In this large population‐based study, we provide more robust estimates of survival and have defined the prognostic factors. OBJECTIVE To describe the survival of patients with primary small cell carcinoma (SCC) of the prostate and assess prognostic factors based on a large population sample. PATIENTS AND METHODS A total of 241 cases of SCC of the prostate were reported to the Surveillance, Epidemiology, and End Results (SEER) registries from 1973 to 2003 of which 191 cases were included in our study. We used the Kaplan–Meier method for estimating survival, and Cox proportional hazard regression modelling to evaluate prognostic variables. RESULTS The overall age‐adjusted incidence rate was 0.278 per 1 000 000 (95% confidence interval, 0.239–0.323). In all, 60.5% presented as metastatic disease compared with 39.5% who presented as local/regional disease (P= 0.012). The 12, 24, 36, 48 and 60 months observed survival rates were 47.9%, 27.5%, 19%, 17% and 14.3% respectively. On univariate analyses, age <60, concomitant low‐grade prostatic adenocarcinoma, absence of metastasis, prostatectomy and radiation therapy were favourable prognostic factors. In multivariate regression modelling, age, pathology and stage were strong predictors of survival. CONCLUSIONS Using the SEER database, we present the largest study describing the epidemiology of primary SCC of the prostate. We found age, concomitant low‐grade prostatic adenocarcinoma, and stage of the disease to be the strongest predictors of survival for patients with prostatic SCC. Future studies evaluating a broader range of clinical and molecular markers are needed to refine the prognostic model of this relatively rare disease.

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Case report: Subcutaneous metastasis from small cell carcinoma of the prostate

Cited by 15 publications

References 9 publications

Cutaneous metastases from prostate cancer revealing neuroendocrine differentiation

Cutaneous metastases from prostate cancer revealing neuroendocrine differentiation

Cutaneous Metastases From Internal Malignancies

Survival of patients with small cell carcinoma of the prostate during 1973–2003: a population‐based study

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