Case report: Strategies for improving outcomes in patients with primary ovarian small-cell neuroendocrine carcinoma

Li, Yingying; Wu, Yueling; Zhang, Ying; Li, Xiaofang

doi:10.3389/fonc.2022.954289

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…SCNECOP mainly affects postmenopausal women 63 and has a median survival of 2 years due to its aggressive biology and high relapse rate 59,88 …”

Section: Pulmonary Typementioning

confidence: 99%

Small‐cell neuroendocrine carcinoma of the female genital tract: A comprehensive overview

Saraei,

Heshmati,

Hosseini

2024

J Neuroendocrinology

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Small‐cell neuroendocrine carcinomas (SCNECs) of the female genital tract are rare and aggressive tumors that are characterized by a high rate of recurrence and poor prognosis. They can arise from various sites within the female genital tract, including the cervix, endometrium, ovary, fallopian tube, vagina, and vulva. They are composed of cells with neuroendocrine features, such as the ability to produce and secrete hormones and peptides, and a high mitotic rate. Immunohistochemical staining for neuroendocrine markers, such as chromogranin A, synaptophysin, and CD56, can aid in the diagnosis of these tumors. This article provides an overview of the epidemiology, etiology, and risk factors associated with these tumors, as well as their clinical presentation, cellular characteristics, diagnosis, and finally the current treatment options for SCNECs, including surgery, chemotherapy, and radiation therapy, alone or in combination.

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“…SCNECOP mainly affects postmenopausal women 63 and has a median survival of 2 years due to its aggressive biology and high relapse rate 59,88 …”

Section: Pulmonary Typementioning

confidence: 99%

Small‐cell neuroendocrine carcinoma of the female genital tract: A comprehensive overview

Saraei,

Heshmati,

Hosseini

2024

J Neuroendocrinology

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Clinical analysis of 12 cases of ovarian neuroendocrine carcinoma

Xing,

Zhang,

Liu

et al. 2024

World J Clin Cases

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BACKGROUND Neuroendocrine neoplasms of the female genital tract are rare. AIM To enhance our clinical understanding of neuroendocrine carcinoma (NEC) of the ovary. METHODS A retrospective review was conducted on 12 patients diagnosed with NEC of the ovary, analyzing clinicopathological characteristics, treatment modalities, and survival status. RESULTS The median age at diagnosis was 34.5 years (range: 20 to 62 years). Among the 12 cases, 9 were small cell carcinoma of the ovary and 3 were large cell NEC. Five cases were stage I tumors, one case was stage IV, and six cases were stage III. Eleven patients underwent surgery as part of their treatment. All patients received adjuvant chemotherapy. Among the 12 patients, one patient received radiotherapy, and one patient with a BRCA2 mutation was administered PARP inhibitor maintenance after chemotherapy. The median progression-free survival was 13 months, and the median overall survival was 19.5 months. Four cases remained disease-free, while eight cases experienced tumor recurrence, including three cases that resulted in death due to disease recurrence. CONCLUSION NEC of the ovary is a rare condition that is more common in women of childbearing age and is associated with aggressive behavior and poor clinical outcomes. Surgical resection remains the mainstay of treatment, with some patients benefiting from adjuvant chemoradiation therapy.

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Case report: Strategies for improving outcomes in patients with primary ovarian small-cell neuroendocrine carcinoma

Cited by 2 publications

References 11 publications

Small‐cell neuroendocrine carcinoma of the female genital tract: A comprehensive overview

Small‐cell neuroendocrine carcinoma of the female genital tract: A comprehensive overview

Clinical analysis of 12 cases of ovarian neuroendocrine carcinoma

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