Case Report: Pulmonary Sporotrichosis with Massive Hemoptysis

Haponik, Edward F.; Hill, Michael K.; Craighead, Claude C.

doi:10.1097/00000441-198904000-00011

Cited by 13 publications

(5 citation statements)

References 23 publications

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“…Pulmonary disease from inhalation of conidia is rare and characterized by cough, low-grade fever, weight loss, mediastinal lymphadenitis, cavitation mimicking tuberculosis, fibrosis, and rarely massive hemoptysis [ 46 , 47 ]. Apical lesions resembling pulmonary tuberculosis may occur in 85% of these cases [ 1 ].…”

Section: Clinical Presentationsmentioning

confidence: 99%

“…Although treatment is prolonged and expensive, complete recovery without scarring is expected in cutaneous sporotrichosis following appropriate therapy. However, compromised pulmonary functions in pulmonary disease, severe disability from chronic osteoarticular sporotrichosis, or occasional scarring may result [ 36 , 47 , 66 ]. Patients with immunosuppression usually require life-long suppressive therapy.…”

Section: Treatment Optionsmentioning

confidence: 99%

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Sporotrichosis: An Overview and Therapeutic Options

Mahajan¹

2014

Dermatology Research and Practice

190

194

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Sporotrichosis is a chronic granulomatous mycotic infection caused by Sporothrix schenckii, a common saprophyte of soil, decaying wood, hay, and sphagnum moss, that is endemic in tropical/subtropical areas. The recent phylogenetic studies have delineated the geographic distribution of multiple distinct Sporothrix species causing sporotrichosis. It characteristically involves the skin and subcutaneous tissue following traumatic inoculation of the pathogen. After a variable incubation period, progressively enlarging papulo-nodule at the inoculation site develops that may ulcerate (fixed cutaneous sporotrichosis) or multiple nodules appear proximally along lymphatics (lymphocutaneous sporotrichosis). Osteoarticular sporotrichosis or primary pulmonary sporotrichosis are rare and occur from direct inoculation or inhalation of conidia, respectively. Disseminated cutaneous sporotrichosis or involvement of multiple visceral organs, particularly the central nervous system, occurs most commonly in persons with immunosuppression. Saturated solution of potassium iodide remains a first line treatment choice for uncomplicated cutaneous sporotrichosis in resource poor countries but itraconazole is currently used/recommended for the treatment of all forms of sporotrichosis. Terbinafine has been observed to be effective in the treatment of cutaneous sporotrichosis. Amphotericin B is used initially for the treatment of severe, systemic disease, during pregnancy and in immunosuppressed patients until recovery, then followed by itraconazole for the rest of the therapy.

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Section: Clinical Presentationsmentioning

confidence: 99%

Section: Treatment Optionsmentioning

confidence: 99%

Sporotrichosis: An Overview and Therapeutic Options

Mahajan¹

2014

Dermatology Research and Practice

190

194

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“…Pulmonary disease is rare. Patients usually present with a cough, low‐grade fever and weight loss, and massive haemoptysis, which can be fatal 13 . Eighty‐five per cent have a lesion in an upper lobe of the lung, and X‐ray appearances may mimic tuberculosis.…”

Section: Extracuticular Sporotrichosismentioning

confidence: 99%

Sporotrichosis

Morris‐Jones

2002

Clinical and Experimental Dermatology

122

118

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Sporotrichosis is a cutaneous fungal infection with a global distribution. The disease has several clinical forms, primarily cutaneous with associated lymphadenopathy. However, dissemination to osteoarticular structures and viscera may occur, both in healthy and immunosuppressed individuals; such disseminated forms usually follow spread after inhalation of fungal spores. Cutaneous infection is usually associated with trauma during the course of outdoor work, and treatment is required for the majority of patients. Potassium iodide (the treatment of choice in endemic areas) is an effective and inexpensive therapy; however, its adverse effects and complicated dosage regimen often weigh against its use in developed countries, where itraconazole is the antimycotic of choice.

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“…As características radiológicas da forma pulmonar primária da esporotricose são: infiltrado apical unilateral ou bilateral, com consolidação e, principalmente, lesões cavitárias crónicas. O aspecto tomográfico pode sugerir infiltrado em vidro fosco, associado a consolidação e presença de cavidades em ápices, indistinguível da tuberculose 12,13,15,16,17 . O quadro radiológico da forma pulmonar associada a doença disseminada revela adenopatia mediastinal e hilar difusa, infiltrado intersticial e alveolar, podendo haver fibrose associada, sendo difícil a sua diferenciação da sarcoidose 10,11 .…”

Section: Discussionunclassified

“…O diagnóstico diferencial das lesões cutâneas é feito com: infecções por Nocardia brasiliensis, micobacterioses atípicas, leixemaniose e tularemia 8,20,21,22 . Deve -se considerar principalmente a tuberculose como diagnóstico diferencial das lesões pulmonares, incluindo também sarcoidose, histoplasmose e neoplasia pulmonar 8,16,23 . O diagnóstico da esporotricose fundamenta-se na:…”

Section: Discussionunclassified