Case Report: Myelin Oligodendrocyte Glycoprotein Antibody-Associated Relapse With COVID-19

Woodhall, Mark; Mitchell, James; Gibbons, Emily; Healy, Sarah; Waters, Patrick; Huda, Saif

doi:10.3389/fneur.2020.598531

Cited by 32 publications

(46 citation statements)

References 9 publications

(9 reference statements)

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“…In our patient, and the three others reported with optic neuritis, [6][7][8] COVID-19 infection presumably triggered an autoimmune response and the production of MOG antibodies. It is unclear whether the patients already had a predisposition to MOG associated disease, as in the described relapse of MOG-AD in a patient during COVID-19, 29 or if the virus set a novel process in motion.…”

Section: Discussionmentioning

confidence: 99%

Optic Neuritis in a Patient with Seropositive Myelin Oligodendrocyte Glycoprotein Antibody During the Post-COVID-19 Period

Zoric¹,

Rajović-Mrkić²,

Čolak³

et al. 2021

IMCRJ

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Reports of neuro-ophthalmological manifestations and complications in patients with coronavirus disease 19 (COVID-19) are still scarce. The aim of this article is to present optic neuritis, as possible post-infectious manifestation of COVID-19. Four weeks after hospitalization for seropositive coronavirus disease 19 (COVID-19), presented as bilateral bronchopneumonia, with radiology and laboratory findings also pointed to high clinical suspicion to COVID-19, a 63-year-old man developed a headache and subacute and profound visual loss on his right eye. The disease presentation was the right eye papillitis. Inflammatory parameters were normal at the time of hospitalization, and IgM and IgG for SARS-CoV-2 were still positive. After corticosteroid pulse therapy, his vision improved significantly and on follow-up visits returned to normal. All laboratory and radiology findings were unremarkable, except for antibodies against SARS-CoV-2 and myelin oligodendrocyte glycoprotein (MOG). We discuss about capacity of SARS-CoV-2 to cause optic neuritis and possible significance of MOG antibodies in similar cases.

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Section: Discussionmentioning

confidence: 99%

Optic Neuritis in a Patient with Seropositive Myelin Oligodendrocyte Glycoprotein Antibody During the Post-COVID-19 Period

Zoric¹,

Rajović-Mrkić²,

Čolak³

et al. 2021

IMCRJ

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“…Importantly, this observation does not hold true for children where relapses can be seen irrespective of serostatus. MOG‐IgG serological reversion also remains a possibility as recently noted in a MOGAD relapse with COVID‐19 90 . On longitudinal MOG‐IgG testing, 1 study found that MOG‐IgG seroreversion occurred in 3% of cases 14 .…”

Section: Maintenance Therapiesmentioning

confidence: 83%

“…Whether negative seroversion should be defined as MOG‐IgG that is persistently undetectable or below an accepted cutoff remains unclear. The clinical relevance of this distinction was highlighted in a recent report of a MOGAD relapse with SARS‐CoV‐2 infection associated with MOG‐IgG serological reversion despite prior persistently subthreshold MOG‐IgG levels 90 …”

Section: Discussionmentioning

confidence: 99%

Treatment of myelin oligodendrocyte glycoprotein immunoglobulin G–associated disease

Healy

Elhadd

Gibbons

et al. 2021

Clinical & Exp Neuroim

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Myelin oligodendrocyte glycoprotein (MOG) immunoglobulin G (IgG)–associated disease (MOGAD) is increasingly recognized as a distinct nosological entity from aquaporin‐4 antibody IgG–positive neuromyelitis optica spectrum disorder (AQP4‐IgG NMOSD). The advent of highly specific MOG‐IgG cell‐based diagnostic assays have helped to refine our understanding of the clinical spectrum of MOGAD. To date, treatment approaches have been largely extrapolated from AQP4‐IgG NMOSD experience, but there is growing evidence of distinct differences in treatment response between these conditions. This review summarizes the current status and understanding of acute and chronic treatments for MOGAD. Timing and duration of treatment, pregnancy, and emerging therapies are also discussed.

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“…The MOG receptor is associated with MOG antibody disease (MOGAD) a neuro-inflammatory condition that may cause inflammation of the optic nerve, the spinal cord and brain. Recent research has shown that SARS-CoV2 does trigger a relapse of MOGAD (Woodhall, 2020).…”

Section: Resultsmentioning

confidence: 99%

“…Some of the detected interactions have already been experimentally confirmed in recent literature, others provide novel insights into the pathology of SARS-CoV2. Notably, the interaction with DPP4 has been suggested to cause a higher mortality rate of diabetics contracting SARS-CoV2 (Valencia, 2020) while the MOG receptor is associated with the MOG antibody disease which relapses in SARS-CoV2 patients (Woodhall, 2020).…”

Section: Introductionmentioning

confidence: 99%

Fast and accurate genome-wide predictions and structural modeling of protein-protein interactions using Galaxy

Guerler

Baker

Beek

et al. 2021

Preprint

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Protein-protein interactions play a crucial role in almost all cellular processes. Identifying interacting proteins reveals insight into living organisms and yields novel drug targets for disease treatment. Here, we present a publicly available, automated pipeline to predict genome-wide protein-protein interactions and produce high-quality multimeric structural models.Application of our method to the Human and Yeast genomes yield protein-protein interaction networks similar in quality to common experimental methods. We identified and modeled Human proteins likely to interact with the papain-like protease of SARS-CoV2’s non-structural protein 3 (Nsp3). We also produced models of SARS-CoV2’s spike protein (S) interacting with myelin-oligodendrocyte glycoprotein receptor (MOG) and dipeptidyl peptidase-4 (DPP4). The presented method is capable of confidently identifying interactions while providing high-quality multimeric structural models for experimental validation.The interactome modeling pipeline is available at usegalaxy.org.

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Case Report: Myelin Oligodendrocyte Glycoprotein Antibody-Associated Relapse With COVID-19

Cited by 32 publications

References 9 publications

Optic Neuritis in a Patient with Seropositive Myelin Oligodendrocyte Glycoprotein Antibody During the Post-COVID-19 Period

Optic Neuritis in a Patient with Seropositive Myelin Oligodendrocyte Glycoprotein Antibody During the Post-COVID-19 Period

Treatment of myelin oligodendrocyte glycoprotein immunoglobulin G–associated disease

Fast and accurate genome-wide predictions and structural modeling of protein-protein interactions using Galaxy

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