Case report: histopathology and molecular pathology analysis on enteric tissue of a COVID-19 patient

Feng, Yinchang; Zeng, Dong; Hu, Lvyin; Yang, Yuexiang; Song, Shu; Shi, Yuhan; Xu, Jingjing; Guo, Wang; Ling, Yun; Qi, Tangkai; Wu, Qifan; Li, Feng; Cheng, Jun; Lu, Hongzhou

doi:10.1186/s13000-021-01082-7

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…At the end, these sections were carried out for staining protocol with the help of dyes like hematoxylin and eosin (H&E) and seen under light microscopy. 36…”

Section: Histopathological Studymentioning

confidence: 99%

Toxicological effects of dimethlybenzeneanthracene in Balb C mice and pharmacological intervention by silk sericin–conjugated silver nanoparticles

Mumtaz,

Ali,

Pervaiz

et al. 2024

Science Progress

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Polycyclic aromatic hydrocarbons (PAHs) such as 7, 12-dimethylbenzneanthracene (DMBA), due to long-term bioaccumulation cause serious physiological processes and behavioral dysfunctions such as cancer, ageing, and hypertension. Silk sericin (SS) is instrumental in cancer applications due to presence of flavonoids and carotenoids which are natural pigments, present in the layer of sericin that has antioxidant and antityrosinase activity. It reduces oxidative stress and suppresses cancer cytokines while interacting with reactive oxygen species (ROS) to stand against lipid peroxidation. Recent research was focused to calculate the pharmacological intervention of sericin-conjugated silver nanoparticles (S-AgNO3 NPs) against DMBA-induced toxicity. For this purpose, SS protein was extracted from silkworm cocoons by degumming process and the prepared S-AgNO3 NPs via a green synthesis. In female albino mice, a total of 50 mg/kg oral administration of DMBA was used for the induction of toxicity which required almost 8 to 10 weeks approximately. After 60 days of experimentation, mice were dissected, blood samples were collected for further hematological and biochemical analysis and were euthanized via cervical dislocation. There was a significant rise in the level of red blood cells, platelets, lymphocytes, and hemoglobin at the highest applied concentration of sericin and its nanoparticles. Similarly, a reasonable decline was observed in the level of white blood cells, neutrophils, eosinophils, and monocytes as compared to the cancer-inducing group. The level of glutathione, lactate dehydrogenase, and alkaline phosphatase as well as immunoglobulins such as immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) were significantly reduced in all treatment groups as compared to the DMBA-induced group. Substantial effects were demonstrated in response to S-AgNO3 NPs II (T) at the highest concentrations (200 mg/kg, BW) as follows: glutathione (2.42 ± 0.26 μmol/L), lactate dehydrogenase (493.6 ± 5.78 U/L), alkaline phosphatase (158.4 ± 6.35 U/L), IgA (4.22 ± 0.19 g/L), IgG (70 ± 1.70 g/L), and IgM (4.76 ± 0.12). The histopathological study of the liver, kidneys, and brain revealed that the DMBA-induced group showed cytotoxic effects against all selected organs of mice that were recovered by treatment of selective compounds but highly effective recovery was seen in S-AgNO3 NPs II (T). These results concluded that silk S-AgNO3 NPs showed significant pharmacological potential against cancer-inducing toxicity.

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“…At the end, these sections were carried out for staining protocol with the help of dyes like hematoxylin and eosin (H&E) and seen under light microscopy. 36…”

Section: Histopathological Studymentioning

confidence: 99%

Toxicological effects of dimethlybenzeneanthracene in Balb C mice and pharmacological intervention by silk sericin–conjugated silver nanoparticles

Mumtaz,

Ali,

Pervaiz

et al. 2024

Science Progress

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“…Histopathology examination demonstrated excessive inflammatory response, intestinal mucosal erosions, and focal inflammatory necrosis with hemorrhage. Viral RNA was found by in situ hybridization in the intestinal tissue [67].…”

Section: Severe Acute Respiratory Syndrome Coronavirusmentioning

confidence: 99%

Viral Enteritis in Solid-Organ Transplantation

Abbas

Zimmer

Florescu

2021

Viruses

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Solid organ transplant recipients are at increased risk for infections due to chronic immunosuppression. Diarrhea is a commonly encountered problem post transplantation, with infectious causes of diarrhea being a frequent complication. Viral infections/enteritides in solid organ transplant recipients often result from frequently encountered pathogens in this population such as cytomegalovirus, adenovirus, and norovirus. However, several emerging viral pathogens are increasingly being recognized as more sensitive diagnostic techniques become available. Treatment is often limited to supportive care and reduction in immunosuppression, though antiviral therapies mayplay a role in the treatment in certain diseases. Viral enteritis is an important entity that contributes to morbidity and mortality in transplant recipients.

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