Case report: Castleman’s disease involving the renal sinus resembling renal cell carcinoma

Abstract

IntroductionCastleman's disease (CD) is a rare benign lymphoproliferative disease that frequently involves the mediastinal thorax and the neck lymph nodes. It rarely affects extrathoracic presentations, with even fewer presentations in the renal sinus.Patient concernsIn this report, we present a case of a 40-year-old woman with no significant past medical history who presented Castleman's disease arising in the renal sinus.Diagnosis and interventionsThe patient visited our hospital with the chief complaint of left renal sinus lesion after renal ultrasonography by regular physical examination. Subsequent abdominal computed tomography urography revealed a soft tissue mass with heterogeneous obvious enhancement in the sinus of the left kidney, which was suspected to be a renal malignant tumor. Hence, the patient underwent a left radical nephrectomy. Histological examination revealed hyperplastic lymphoid follicles in the renal sinus and was finally diagnosed as Castleman's disease of the hyaline vascular type.OutcomesFive days after the surgery procedure, the patient was discharged.ConclusionDue to the low incidence of Castleman's disease in renal sinus, there is a strong likelihood of missed diagnosis or misdiagnosis, and it is, therefore, important to be aware of the risk. Heightened awareness of this disease and its radiographic manifestations may prompt consideration of this diagnosis. Therefore, we explored the radiologic findings to find out some radiologic features suggesting this condition to help clinicians to schedule nephron-sparing surgery in the future.

Misdiagnosis of renal pelvic unicentric Castleman disease: a case report

“…This case report adds to the existing literature on the variable manifestations of Castleman disease and emphasizes the value of imaging and histopathological analysis in arriving at an accurate diagnosis. Since it is rare, few previously published studies reported cases of CD involving the renal sinus (Table 1) (8)(9)(10)(11)(12)(13)(14)(15). The presentation of the patients is unspecific in all of the reported cases.…”