Case of metastatic pulmonary carcinoma in optic disc diagnosed from results of biopsy performed during vitrectomy surgery

Abstract

There are few reports of secondary optic disc tumors and pathological biopsy findings are rare. When a milky white tumor is observed extending from the optic disc, a possible differential diagnosis is metastatic neoplasm.

Metastatic squamous cell carcinoma masquerading as acute retinal necrosis

“…MRI of the head and orbits showed heterogeneous thickening throughout the intraorbital optic nerve but was otherwise non-revealing for metastases. 13 …”

Metastatic squamous cell carcinoma masquerading as acute retinal necrosis

“…MRI of the head and orbits showed heterogeneous thickening throughout the intraorbital optic nerve but was otherwise non-revealing for metastases. 13 …”

Optic disc metastasis presenting as an initial sign of non-small-cell lung cancer: a case report

“…2 To our knowledge, metastatic tumors in the optic disc are extremely rare, and few case reports have been published. [3][4][5][6][7][8][9][10][11][12][13][14] Previously published studies on involving optic disc metastasis are listed in Table 1. Specifically, in these published cases, the diagnosis of optic disc metastasis was easily established because all patients already had a clear history of primary tumors (Table 1).…”

Vitreous Diagnosis in Neoplastic Diseases

“…Vitrectomy has helped to diagnose metastatic cutaneous melanoma in difficult cases like nonpigmented vitreous clumps [ 100 ] and thickened posterior vitreous membranes [ 101 ], and moreover can be therapeutic in these cases. Carcinomas also can metastasize directly in the vitreous or indirectly by means of vitreal seeds from an underlying choroidal, retinal, or optic nerve infiltration, and both vitrectomy or fine-needle aspiration cytology can help in the diagnosis [ 102 , 103 ].…”

Metastatic squamous cell carcinoma masquerading as acute retinal necrosis

“…MRI of the head and orbits showed heterogeneous thickening throughout the intraorbital optic nerve but was otherwise non-revealing for metastases. 13 …”

Optic disc metastasis presenting as an initial sign of non-small-cell lung cancer: a case report

“…2 To our knowledge, metastatic tumors in the optic disc are extremely rare, and few case reports have been published. [3][4][5][6][7][8][9][10][11][12][13][14] Previously published studies on involving optic disc metastasis are listed in Table 1. Specifically, in these published cases, the diagnosis of optic disc metastasis was easily established because all patients already had a clear history of primary tumors (Table 1).…”

Vitreous Diagnosis in Neoplastic Diseases

“…Vitrectomy has helped to diagnose metastatic cutaneous melanoma in difficult cases like nonpigmented vitreous clumps [ 100 ] and thickened posterior vitreous membranes [ 101 ], and moreover can be therapeutic in these cases. Carcinomas also can metastasize directly in the vitreous or indirectly by means of vitreal seeds from an underlying choroidal, retinal, or optic nerve infiltration, and both vitrectomy or fine-needle aspiration cytology can help in the diagnosis [ 102 , 103 ].…”

Metastatic squamous cell carcinoma masquerading as acute retinal necrosis

“…MRI of the head and orbits showed heterogeneous thickening throughout the intraorbital optic nerve but was otherwise non-revealing for metastases. 13 …”

Optic disc metastasis presenting as an initial sign of non-small-cell lung cancer: a case report

“…2 To our knowledge, metastatic tumors in the optic disc are extremely rare, and few case reports have been published. [3][4][5][6][7][8][9][10][11][12][13][14] Previously published studies on involving optic disc metastasis are listed in Table 1. Specifically, in these published cases, the diagnosis of optic disc metastasis was easily established because all patients already had a clear history of primary tumors (Table 1).…”

Vitreous Diagnosis in Neoplastic Diseases

“…Vitrectomy has helped to diagnose metastatic cutaneous melanoma in difficult cases like nonpigmented vitreous clumps [ 100 ] and thickened posterior vitreous membranes [ 101 ], and moreover can be therapeutic in these cases. Carcinomas also can metastasize directly in the vitreous or indirectly by means of vitreal seeds from an underlying choroidal, retinal, or optic nerve infiltration, and both vitrectomy or fine-needle aspiration cytology can help in the diagnosis [ 102 , 103 ].…”