Case of human Dirofilaria repens infection manifested by cutaneous larva migrans syndrome

Antolová, Daniela; Miterpáková, Martina; Paraličová, Zuzana

doi:10.1007/s00436-015-4499-7

Cited by 20 publications

(12 citation statements)

References 22 publications

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“…Dirofilarial infections are relatively often accompanied with the parasite subcutaneous migration, and even cutaneous larva migrans syndrome was recorded in Slovak patient recently (6). Herein we present a rare and remarkable case of ocular dirofilariasis manifested by foregoing subcutaneous migration accompanied by severe headache symptoms.…”

Section: Dirofilariasis; Dirofilaria Repens;mentioning

confidence: 87%

“…The helminths occur in the form of a cystic lesion or are directly visible (3,11), with one, exceptionally two individuals detected (12). Despite of ocular dirofilariasis represents still less common form of the infection in comparison with subcutaneous form, during the last two decades progressive increase of its incidence has been reported in various European countries including Serbia, Greece, Belgium or Denmark (6,11,13,14).…”

Section: Discussionmentioning

confidence: 99%

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Ocular Dirofilariasis after Clinically Manifested Subcutaneous Migration of the Parasite: A Case Report

Ondriska

Boldiš

Stanislavová

et al. 2020

IJPA

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Dirofilaria repens is the causative agent of human subcutaneous or, less often, ocular dirofilariasis. The work presents a rare case of ocular dirofilariasis manifested by previous subcutaneous migration accompanied by severe headache symptoms. In February 2017, a 58-yr-old man from Trnava region, western Slovakia, noticed red and itchy stripes on his left leg. Inflamed but painless stripes disappeared and showed up again every 5–7 days, migrating gradually towards the head. Approximately one month after the first skin´s alterations, strong pain in the left temple, with the swelling of the left face and the enlargement of mandibular lymph nodes appeared. Several days later, the patient felt excruciating pain of the right eyeball accompanied by strong nausea and subsequent vomiting. Ocular examination revealed the presence of a live worm in the subconjunctival space and morphological and molecular analyses of extracted helminth confirmed D. repens as etiological agent of the infection. According to clinical manifestation of the infection, it could be supposed that ocular form of the disease was the result of the migration of a parasite through the subcutaneous tissues. Moreover, a rare phenomenon of lymphadenitis of underlying lymph nodes and the swelling of left face accompanied the migration.

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Section: Dirofilariasis; Dirofilaria Repens;mentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Ocular Dirofilariasis after Clinically Manifested Subcutaneous Migration of the Parasite: A Case Report

Ondriska

Boldiš

Stanislavová

et al. 2020

IJPA

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“…A study of 74 cases of creeping dermatitis in Paris mainly found hookworm-related cutaneous larva migrans (HrCLM), very few cases of gnathostomiasis, loiasis, and cutaneous pili migrans, whereas there were no cases of dirofilariasis [20]. In Europe, three cases of human dirofilariasis have been reported in the literature with a creeping dermatitis episode: one in France with facial lesions [8], another in Italy with abdominal lesions [9], and the last one in Slovakia with cervical lesions [1]. All the cases developed in a subcutaneous nodule.…”

Section: Discussionmentioning

confidence: 99%

Oral migration of Dirofilaria repens after creeping dermatitis

et al. 2020

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We report an autochthonous case of oral dirofilariasis in a 46-year-old female patient exposed in South-Eastern France. The patient first presented eyelid creeping dermatitis of one-week duration, then a sub-mucosal nodule appeared in the cheek. The entire nodule was removed surgically. Histologically, the nodule appeared as inflammatory tissue in which a worm was seen. The molecular analysis, based on cox1 and 12S sequences, identified Dirofilaria repens. Ivermectin treatment was given prior to diagnosis, while taking into consideration the most common causes of creeping dermatitis, but treatment was ineffective. The oral form of dirofilariasis is uncommon and could lead to diagnostic wandering.

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“…Only one report of circulating microfilaria in a human exists in medical literature [7] and a case report showing the present of microfilaria in a nodule examinated by fine needle aspiration [8].…”

Section: Discussionmentioning

confidence: 99%

Human Dirofilariasis Presenting as Scrotal Mass

Chiaramonte¹

2017

JURNOA

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Surgery Unit complaining a painless nodule on his left hemi scrotum (ASM). He had neither pathological history nor was in contact with dogs or other animals and never visited other countries.The physical examination revealed no pathological findings except for a single painless hard nodule of 1 cm at the apex of the scrotum with any connection to the testis. The skin over the nodule was normal without any signs of inflammation and the inguinal lymph nodes were not palpable Routine laboratory tests of the blood showed no abnormal values for the age. Tumors markers as βHCG and α-fetoprotein were within normal range.Suspecting an extra-testicular neoplasm an ultrasound scan with high-resolution linear probe 10 -12 MHz of the nodule was performed. It showed the presence of an anechoic cystic formation without any vascularization in its contest or vascular pole at the color-doppler integration. Within a cyst mass a tubular coiled structure with parallel echogenic wall in continuous movements was found: to identify the species of worm specialist opinion was requested.The characteristic pattern movements of the nematode (filaria dance sign-FDS) led to diagnosis of human subcutaneous dirofiliasis (HSD). Testicular tissue was normal.(FIGURE 1).The surgery was performed under general anesthesia with minor surgery approach by a transversal scrotal incision of less than 1 cm over the nodule. The mass wasn't in connection with testicular or funicular structures. It was isolated from the dartos without any damage to the capsule and was enucleated intact (FIGURE 2).The hystopathological examination showed a simil-cystic structure with granulomatous inflammatory wall with a high number of eosinophils and a tubular structure of 10 cm of length inside moving when placed in physiological solution (FIGURE 3).The diagnosis of infection from Dirofilariarepens was based on the morphological characteristic of the worm that displayed the tipical features of a female. AbstractA large spectrum of pathology may present in children as an asymptomatic scrotal mass (ASM) ranging from congenital to neoplastic lesions.We observed a 11 months old child referred to us for suspicion of neoplasm presenting with an asymptomatic scrotal mass.High frequency scrotal sonography enabled diagnosis of nematode infection (Dirofilaria repens): viability of the adult worms was assessed by looking for the animated documentation of filarial dance sign (FDS).Differentiation from malignancy allowed an appropriate management consisting in minor surgery.Human Subcutaneous Dirofilariasis (HSD) is an endemic zoonosis spread throughout the world, with dogs and cats being the definitive host for this parasite. Human infections caused by Dirofilaria repens have been reported in Eastern Europe, Mediterranean area, central and Southern Asia, transmitted by various species of mosquitoes and usually presented as subcutaneous nodule.Extra-testicular pathologies are encountered relatively infrequently but awareness of different possible etiology avoids unnecessary extensive s...

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Case of human Dirofilaria repens infection manifested by cutaneous larva migrans syndrome

Cited by 20 publications

References 22 publications

Ocular Dirofilariasis after Clinically Manifested Subcutaneous Migration of the Parasite: A Case Report

Ocular Dirofilariasis after Clinically Manifested Subcutaneous Migration of the Parasite: A Case Report

Oral migration of Dirofilaria repens after creeping dermatitis

Human Dirofilariasis Presenting as Scrotal Mass

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