Cascading network failure across the Alzheimer’s disease spectrum

Abstract

Subsystems within the default mode network are differentially affected in Alzheimer’s disease. Jones et al. present an in-depth analysis of changes within these subsystems and relate them to biomarker profiles across the Alzheimer’s disease spectrum. Results support a cascading network failure model of Alzheimer’s disease.

Differentiation of Alzheimer's disease based on local and global parameters in personalized Virtual Brain models

“…This suggests that the effects of excitation and inhibition are not straightforward and often unpredictable in a complex system like the brain. The positive cognition correlate of excitation that we found is in contrast with our findings in the Limbic SubNet (where cognition correlated negatively with excitation), as well as with the damaging effects of over-excitation that have consistently been reported ( Busche and Konnerth, 2015 ; Celone et al, 2006 ; Dickerson et al, 2005 ; Gleichmann et al, 2011 ; Gleichmann and Mattson, 2010 ; Jones et al, 2016 ; Sperling et al, 2010 ). Interestingly, similar unpredictability of excitation on function in AD has been reported previously ( de Haan et al, 2017 ).…”

Differentiation of Alzheimer's disease based on local and global parameters in personalized Virtual Brain models

“…This suggests that the effects of excitation and inhibition are not straightforward and often unpredictable in a complex system like the brain. The positive cognition correlate of excitation that we found is in contrast with our findings in the Limbic SubNet (where cognition correlated negatively with excitation), as well as with the damaging effects of over-excitation that have consistently been reported ( Busche and Konnerth, 2015 ; Celone et al, 2006 ; Dickerson et al, 2005 ; Gleichmann et al, 2011 ; Gleichmann and Mattson, 2010 ; Jones et al, 2016 ; Sperling et al, 2010 ). Interestingly, similar unpredictability of excitation on function in AD has been reported previously ( de Haan et al, 2017 ).…”

Dysfunction of the episodic memory network in the Alzheimer’s disease cascade

“…4A). This is in contrast to studies suggesting that episodic memory circuitry dysfunction may appear as one of the earliest symptoms in the cascade 46 .…”

Precuneus Failures in Subjects of the PSEN1 E280A Family at Risk of Developing Alzheimer’s Disease Detected Using Quantitative Electroencephalography

“…Our results are not only in agreement with previous results in E280a carriers, but also in concordance with those findings that had been reported the posterior regions of the DMN as the firsts region with altered activity previous to the clinical symptoms [58].…”

Differentiation of Alzheimer's disease based on local and global parameters in personalized Virtual Brain models

“…This suggests that the effects of excitation and inhibition are not straightforward and often unpredictable in a complex system like the brain. The positive cognition correlate of excitation that we found is in contrast with our findings in the Limbic SubNet (where cognition correlated negatively with excitation), as well as with the damaging effects of over-excitation that have consistently been reported ( Busche and Konnerth, 2015 ; Celone et al, 2006 ; Dickerson et al, 2005 ; Gleichmann et al, 2011 ; Gleichmann and Mattson, 2010 ; Jones et al, 2016 ; Sperling et al, 2010 ). Interestingly, similar unpredictability of excitation on function in AD has been reported previously ( de Haan et al, 2017 ).…”

Dysfunction of the episodic memory network in the Alzheimer’s disease cascade

“…4A). This is in contrast to studies suggesting that episodic memory circuitry dysfunction may appear as one of the earliest symptoms in the cascade 46 .…”

Precuneus Failures in Subjects of the PSEN1 E280A Family at Risk of Developing Alzheimer’s Disease Detected Using Quantitative Electroencephalography

“…Our results are not only in agreement with previous results in E280a carriers, but also in concordance with those findings that had been reported the posterior regions of the DMN as the firsts region with altered activity previous to the clinical symptoms [58].…”

Differentiation of Alzheimer's disease based on local and global parameters in personalized Virtual Brain models

“…This suggests that the effects of excitation and inhibition are not straightforward and often unpredictable in a complex system like the brain. The positive cognition correlate of excitation that we found is in contrast with our findings in the Limbic SubNet (where cognition correlated negatively with excitation), as well as with the damaging effects of over-excitation that have consistently been reported ( Busche and Konnerth, 2015 ; Celone et al, 2006 ; Dickerson et al, 2005 ; Gleichmann et al, 2011 ; Gleichmann and Mattson, 2010 ; Jones et al, 2016 ; Sperling et al, 2010 ). Interestingly, similar unpredictability of excitation on function in AD has been reported previously ( de Haan et al, 2017 ).…”

Dysfunction of the episodic memory network in the Alzheimer’s disease cascade

“…4A). This is in contrast to studies suggesting that episodic memory circuitry dysfunction may appear as one of the earliest symptoms in the cascade 46 .…”

Precuneus Failures in Subjects of the PSEN1 E280A Family at Risk of Developing Alzheimer’s Disease Detected Using Quantitative Electroencephalography

“…Our results are not only in agreement with previous results in E280a carriers, but also in concordance with those findings that had been reported the posterior regions of the DMN as the firsts region with altered activity previous to the clinical symptoms [58].…”