Carvone and Perillaldehyde Interfere with the Serum-Induced Formation of Filamentous Structures inCandidaalbicansat Substantially Lower Concentrations than Those Causing Significant Inhibition of Growth

McGeady, Paul; Wansley, Daniel; Logan, David A.

doi:10.1021/np010621l

Cited by 55 publications

(32 citation statements)

References 11 publications

(13 reference statements)

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“…143 A similar observation is reported from perillaldehyde (79) and carvone (83), which both inhibit the transformation of Candida to the filamentous form at concentrations far lower than the growth inhibitory concentration. 190 Sesquiterpene inhibitors can be attributed to the compound groups of hydrocarbons (90,91), alcohols (92-96, 100, 103), bisabolan type compounds (100-103), phenols (98-101), dialdehydes (105)(106)(107), and lactones (108)(109)(110)(111)(112) having an exocyclic double bound as shown in Figure 3. A difference in the mechanisms of antimicrobial and mutagenic activity has been demonstrated by the example of dialdehydes, 191 of which polygodial (107) turned out to be as an antifungal, nonmutagenic compound.…”

Section: E Vapor Phase Activity Testsmentioning

confidence: 99%

Anticandidal low molecular compounds from higher plants with special reference to compounds from essential oils

Pauli

2005

Medicinal Research Reviews

104

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The most active low molecular weight compounds from higher plants against Candida species are compiled from a database of antimicrobials (Amicbase) to find out new hints on their mechanism of action. The selected compounds possess strong inhibitory activities in vitro against Candida species either in the agar diffusion test, bioautography, agar dilution test, serial dilution test, or activity in the vapour phase. The test conditions are listed thoroughly and aspects of the different methods and recent developments in the testing of anticandidal drugs are discussed. The anticandidal spectra of drugs, antiseptics, and disinfectants licensed on the major markets are given for comparison of activities with compounds from natural sources. So far known mechanisms of action are described and some new structure-activity relationships are deduced from relationships between biological activities and chemical and physical parameters. Main specific targets of natural anticandidals are the ergosterol pathway, respiratory chain, and chitin biosynthesis.

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Section: E Vapor Phase Activity Testsmentioning

confidence: 99%

Anticandidal low molecular compounds from higher plants with special reference to compounds from essential oils

Pauli

2005

Medicinal Research Reviews

104

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“…Several categories of natural products and synthetic chemicals have been screened and evaluated for their efficacy against C. albicans adhesion and morphological transition in recent years. Carvone and perillaldehyde were found to inhibit the formation of C. albicans filamentous structures (McGeady et al ., 2002). Quorum sensing molecules such as farnesoic acid and cis ‐2‐dodecenoic acid (BDSF) inhibit C. albicans hyphae formation and appear to play a key role in regulating the C. albicans morphological transition (Oh et al ., 2001; Kim et al ., 2002; Boon et al ., 2008; Deng et al ., 2010).…”

Section: Introductionmentioning

confidence: 99%

(1‐aryloxy‐2‐hydroxypropyl)‐phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition

Zhao

Huang

Sun

et al. 2018

Microbial Biotechnology

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SummaryClinical treatment of Candida albicans infections has become more difficult due to the limited development of antifungal agents and the rapid emergence of drug resistance. In this study, we demonstrate the synthesis of a series of piperazine derivatives and the evaluation of their inhibitory activity against C. albicans virulence. Thirty‐four (1‐aryloxy‐2‐hydroxypropyl)‐phenylpiperazine derivatives, including 25 new compounds, were synthesized and assessed for their efficacy against the physiology and pathogenesis of C. albicans. Several compounds strongly inhibited the morphological transition and virulence of C. albicans cells, although they did not influence the growth rate of the fungal pathogen. A leading novel compound, (1‐(4‐ethoxyphenyl)‐4‐(1‐biphenylol‐2‐hydroxypropyl)‐piperazine), significantly attenuated C. albicans virulence by interfering with the process of hyphal development, but it showed no cytotoxicity against human cells at a micromolar level. These findings suggest that (1‐aryloxy‐2‐hydroxypropyl)‐phenylpiperazine derivatives could potentially be developed as novel therapeutic agents for the clinical treatment of C. albicans infections by interfering with morphological transition and virulence.

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“…It is well known that Candida infections are usually difficult to eradicate completely in patients receiving antifungal agents continuously for long periods of time [20] [21]. Furthermore, it has been reported that C. parapsilosis, C. tropicalis, and C. glabrata infections have become more common in recent years [22].…”

mentioning

confidence: 99%

Anticandidal Activity of the Essential Oil of Nepeta transcaucasicaGrossh.

İşcan

Köse

Demirci

et al. 2011

Chemistry & Biodiversity

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Hydrodistallation of the aerial parts of Nepeta transcaucasica Grossh. (Lamiaceae), collected in Ağrı, Doğubayazıt Province, afforded an essential oil that was characterized by GC and GC/MS analyses. Twenty-seven compounds, representing 97.69% of the total oil composition, were identified, and 4aα,7α,7aβ-nepetalactone (1; 39%), 4aα,7α,7aα-nepetalactone (2; 28%), and germacrene D (3; 15%) constituted the major components. The anticandidal effects of the oil were evaluated against seven Candida strains by using the broth microdilution method. The oil showed good inhibitory effects against C. glabrata and C. tropicalis at minimal inhibitory concentrations (MICs) of 0.09 and 0.375 mg/ml, respectively.

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Carvone and Perillaldehyde Interfere with the Serum-Induced Formation of Filamentous Structures inCandidaalbicansat Substantially Lower Concentrations than Those Causing Significant Inhibition of Growth

Cited by 55 publications

References 11 publications

Anticandidal low molecular compounds from higher plants with special reference to compounds from essential oils

Anticandidal low molecular compounds from higher plants with special reference to compounds from essential oils

(1‐aryloxy‐2‐hydroxypropyl)‐phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition

Anticandidal Activity of the Essential Oil of Nepeta transcaucasicaGrossh.

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