2013
DOI: 10.1007/s12031-013-0069-6
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Carvacrol (CAR), a naturally occurring phenolic monoterpene, has been demonstrated to possess various biological actions. The present study was designed to investigate the neuroprotective effect of CAR on diabetes-associated cognitive deficit (DACD) in a rat model of diabetes and exploring its potential molecular mechanism. Diabetic rats were treated with CAR by the doses of 25, 50, and 100 mg/kg for 7 weeks. Morris water maze was used for behavioral evaluation of memory. Cytoplasmic and nuclear fractions of c… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

4
27
1

Year Published

2014
2014
2024
2024

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 56 publications
(32 citation statements)
references
References 34 publications
4
27
1
Order By: Relevance
“…In the present study, carvacrol improved glucose level and MDA by improving level of antioxidants. Similarly, Deng et al reported that the use of carvacrol could prevent increased oxidative stress, also TNF-α andNF-κB signaling in diabetic rats [30][31][32]. As mentioned earlier that diabetes is related with inflammation and thus our result shows that carvacrol decreases inflammation in diabetic rat model.…”
Section: Discussionsupporting
confidence: 82%
“…In the present study, carvacrol improved glucose level and MDA by improving level of antioxidants. Similarly, Deng et al reported that the use of carvacrol could prevent increased oxidative stress, also TNF-α andNF-κB signaling in diabetic rats [30][31][32]. As mentioned earlier that diabetes is related with inflammation and thus our result shows that carvacrol decreases inflammation in diabetic rat model.…”
Section: Discussionsupporting
confidence: 82%
“…Our results illustrated that naringin significantly inhibited the oxidative stresses (decreased SOD and increased MDA content) to improve cognition in diabetic rats. Additionally, in human diabetes, inflammatory cytokines could cause serious neuronal damages in the hippocampus, be involved in the occurrence of neurodegenerative diseases, and be negatively correlated with cognitive deficits (25-26). In the current research, the activities of major inflammatory cytokines including TNF-α, IL-1β, and IL-6 were all augmented in the diabetic rat hippocampus, and naringin treatment significantly inhibited the proinflammatory response, to improve the cognitive decline in DACD.…”
Section: Discussionmentioning
confidence: 99%
“…Cumulative evidence demonstrated that the marked release of inflammatory mediators were observed in diabetes-induced cognitive decline of rats [13,16]. Indeed, TNF-α was shown to inhibit the development of long term potentiation in the dentate gyrus subregion of the rat hippocampus [26].…”
Section: Discussionmentioning
confidence: 99%
“…Treatment with antioxidants has been shown to protect neurons against diabetes-induced excitotoxicity and neurodegenerative conditions [15]. Additionally, diabetes is also accompanied with the marked release of inflammatory cytokines [13,16]. A recent report demonstrated that the activated nuclear transcription factor κB (NF-κB) signaling pathway led to diabetes-induced cognitive impairment [17].…”
Section: Introductionmentioning
confidence: 99%