Carrier Medium Exchange through Ultrasonic Particle Switching in Microfluidic Channels

Petersson, Filip; Nilsson, Andréas; Jönsson, Henrik; Laurell, Thomas

doi:10.1021/ac048394q

Cited by 142 publications

(150 citation statements)

References 16 publications

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“…Particle medium exchange refers to the transfer of particles from one suspending medium to the other for their washing, coating or any other purposes [135]. As reviewed above, viscoelastic polymer solutions have been widely used to focus and separate PS particles of various sizes, shapes and properties (e.g., magnetization).…”

Section: Particle Medium Exchangementioning

confidence: 99%

Particle manipulations in non-Newtonian microfluidics: A review

Liu

et al. 2017

Journal of Colloid and Interface Science

235

192

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a b s t r a c tMicrofluidic devices have been widely used since 1990s for diverse manipulations of particles (a general term of beads, cells, vesicles, drops, etc.) in a variety of applications. Compared to the active manipulation via an externally imposed force field, the passive manipulation of particles exploits the flow-induced intrinsic lift and/or drag to control particle motion with several advantages. Along this direction, inertial microfluidics has received tremendous interest in the past decade due to its capability to handle a large volume of samples at a high throughput. This inertial lift-based approach in Newtonian fluids, however, becomes ineffective and even fails for small particles and/or at low flow rates. Recent studies have demonstrated the potential of elastic lift in non-Newtonian fluids for manipulating particles with a much smaller size and over a much wider range of flow rates. The aim of this article is to provide an overview of the various passive manipulations, including focusing, separation, washing and stretching, of particles that have thus far been demonstrated in non-Newtonian microfluidics.

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Section: Particle Medium Exchangementioning

confidence: 99%

Particle manipulations in non-Newtonian microfluidics: A review

Liu

et al. 2017

Journal of Colloid and Interface Science

235

192

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“…[11][12][13][14][15][16] Likewise, the development of continuous-flow-based separation and manipulation of particles and cells has progressed rapidly with the advent of precision microfabricated flow-through resonators operating in the laminar flow regime. [17][18][19][20][21][22][23][24][25][26] Both the area of acoustic trapping and continuous separation/manipulation show great promise for applications within flow cytometry, and much of the current technological development targets cell biology.…”

Section: Introductionmentioning

confidence: 99%

Measuring the local pressure amplitude in microchannel acoustophoresis

et al. 2010

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A new method is reported on how to measure the local pressure amplitude and the Q factor of ultrasound resonances in microfluidic chips designed for acoustophoresis of particle suspensions. The method relies on tracking individual polystyrene tracer microbeads in straight water-filled silicon/glass microchannels. The system is actuated by a PZT piezo transducer attached beneath the chip and driven by an applied ac voltage near its eigenfrequency of 2 MHz. For a given frequency a number of particle tracks are recorded by a CCD camera and fitted to a theoretical expression for the acoustophoretic motion of the microbeads. From the curve fits we obtain the acoustic energy density, and hence the pressure amplitude as well as the acoustophoretic force. By plotting the obtained energy densities as a function of applied frequency, we obtain Lorentzian line shapes, from which the resonance frequency and the Q factor for each resonance peak are derived. Typical measurements yield acoustic energy densities of the order of 10 J/m 3 , pressure amplitudes of 0.2 MPa, and Q factors around 500. The observed half wavelength of the transverse acoustic pressure wave is equal within 2% to the measured width w ¼ 377 mm of the channel.

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“…13 On the other hand, ACP offers an ability to create forces in a wider portion of the micro-channel with a lower selectivity, which makes ACP a good candidate for cell manipulation applications such as cell washing. 10,[14][15][16][17] Therefore, for the application of automated cell separation systems where cell washing and cell separation is performed on a single device, the use of ACP (in cell washing) with DEP (in cell separation) may be a subtle and promising solution with superior results compared to single mode of separation devices.…”

Section: Introductionmentioning

confidence: 99%

An integrated acoustic and dielectrophoretic particle manipulation in a microfluidic device for particle wash and separation fabricated by mechanical machining

et al. 2016

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In this study, acoustophoresis and dielectrophoresis are utilized in an integrated manner to combine the two different operations on a single polydimethylsiloxane (PDMS) chip in sequential manner, namely, particle wash (buffer exchange) and particle separation. In the washing step, particles are washed with buffer solution with low conductivity for dielectrophoretic based separation to avoid the adverse effects of Joule heating. Acoustic waves generated by piezoelectric material are utilized for washing, which creates standing waves along the whole width of the channel. Coupled electro-mechanical acoustic 3D multi-physics analysis showed that the position and orientation of the piezoelectric actuators are critical for successful operation. A unique mold is designed for the precise alignment of the piezoelectric materials and 3D side-wall electrodes for a highly reproducible fabrication. To achieve the throughput matching of acoustophoresis and dielectrophoresis in the integration, 3D side-wall electrodes are used. The integrated device is fabricated by PDMS molding. The mold of the integrated device is fabricated using high-precision mechanical machining. With a unique mold design, the placements of the two piezoelectric materials and the 3D sidewall electrodes are accomplished during the molding process. It is shown that the proposed device can handle the wash and dielectrophoretic separation successfully. V C 2016 AIP Publishing LLC.

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Carrier Medium Exchange through Ultrasonic Particle Switching in Microfluidic Channels

Cited by 142 publications

References 16 publications

Particle manipulations in non-Newtonian microfluidics: A review

Particle manipulations in non-Newtonian microfluidics: A review

Measuring the local pressure amplitude in microchannel acoustophoresis

An integrated acoustic and dielectrophoretic particle manipulation in a microfluidic device for particle wash and separation fabricated by mechanical machining

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