Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso

Zoure, Abdou Azaque; Amegnona, Lanyo Jospin; Zongo, Nayi; Kiendrebeogo, Isabelle Touwendpoulimdé; Sorgho, Pegdwendé Abel; Zongo, Fabienne Ingrid; Yonli, Albert Théophane; Sombié, Herman Karim; Bambara, Augustin Tozoula; Sawadogo, Alphonse; Ouedraogo, Marie Nabonswindé Lamoussa; Traoré, Lassina; Zongo, Sidnooma Véronique; Lallogo, Doriane Tatiana; Bazié, Bapio Valery Jean Télesphore Elvira; Zohoncon, Théodora Mahoukèdè; Dijgma, Florencia W.; Simporé, Jacques

doi:10.1515/biol-2021-0113

Cited by 6 publications

(6 citation statements)

References 46 publications

(59 reference statements)

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“…These results contrasted with observations in other diseases (e.g., breast cancer); HLA-DRB1*11 showed no association, while the deletion of this allele correlated with obesity. 19 Lymph nodes are crucial for several biological processes, including the development of metastasis and immune modulation. 26 Lymph-node invasion is a prognostic factor for many cancers such as CRC 27 and pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

“…CC is one of the most common malignancies worldwide. 1 Previous studies have highlighted the link between HLA class II gene polymorphisms and several diseases including type I diabetes 14 and aplastic anemia, 15 as well as several cancers including nasopharyngeal carcinoma, 16 glioblastoma, 17 CRC, 8,18 breast cancer, 19 and cervical cancer. 20 To the best of our knowledge, the association of DRB1 and DQB1 alleles/haplotypes with CC is not yet investigated.…”

Section: Discussionmentioning

confidence: 99%

“…These results contrasted with observations in other diseases (e.g., breast cancer); HLA-DRB1*11 showed no association, while the deletion of this allele correlated with obesity. 19…”

Section: Discussionmentioning

confidence: 99%

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HLA class II polymorphisms as prognostic biomarkers for right and left-sided colon cancer

Attia,

Lagha,

Mezlini

et al. 2024

Int J Biol Markers

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Background Colon cancer (CC) is one of the most common malignancies worldwide. Characterization of new prognostic biomarkers for right-sided CC (RCC) and left-sided CC (LCC) may contribute to improving early detection. An association of human leukocyte antigens class II (HLA-II) with the predisposition to CC was suggested. Aim of the study We evaluated the association of DRB1 and DQB1 with the risk of LCC and RCC. Patients and methods Our study comprised 93 CC patients and 100 healthy controls. Genotyping of HLA class II alleles were performed by the Polymerase Chain Reaction Sequence-Specific Primers (PCR-SSP). Results DRB1*03 was positively associated with CC. In contrast, DRB1*11, DRB1*13, DQB1*03, and DQB1*05 were negatively linked to CC. Haplotype analysis revealed that DRB1*04-DQB1*04 and DRB1*09-DQB1*02 were positive, while DRB1*01-DQB1*05, DRB1*04-DQB1*03, DRB1*07-DQB1*02, DRB1*11-DQB1*03, DRB1*11-DQB1*05, and DRB1*13-DQB1*06 were negatively associated with CC. For sigmoid CC, DRB1*13, DRB1*11, and DQB1*05 were negative, while DRB1*04-DQB1*02, and DRB1*07-DQB1*03 were positively associated. DRB1*03 and DRB1*04-DQB1*04 were positive, while DRB1*11 and DQB1*03 were negatively linked to RCC. According to the LCC, DRB1*07, DRB1*11, DQB1*03, DQB1*05, and DRB1*07-DQB1*02 were negative. In contrast, DRB1*09-DQB1*02 was positively associated with LCC. Stratified analysis revealed that DRB1*11 is associated with higher risk of metastasis in CC and sigmoid CC, and tolerance to treatment in RCC. DQB1*03 was associated with lymph-node invasion in CC. Conclusion DRB1 and DQB1 polymorphisms could be used as future biomarkers for the early detection of subjects at a higher risk of developing RCC and LCC, metastasis in sigmoid CC, and tolerance to treatment in RCC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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HLA class II polymorphisms as prognostic biomarkers for right and left-sided colon cancer

Attia,

Lagha,

Mezlini

et al. 2024

Int J Biol Markers

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“…Kagone et al 3 found a protective role of a variant of the DC‐SIGN promoter and of genetic resistance to HIV‐1 in serodiscordant couples in Burkina Faso; Compaoré et al (2016) 27 found that certain variants of APOBEC3G would protect against HIV‐1 infection 4,28,29 . Sorgho et al (2018−2019) showed that certain variants of KIR genes were associated with protection against HBV and HIV‐1 infection 4,29 and Zoure et al 30 found that HLA‐DRB1*11 allele deletion was associate with obesity/overweight, which is a risk for cancer development 30 in the same country.…”

Section: Discussionmentioning

confidence: 99%

KIR2DL5B and HLA DRB1*12 alleles seems to be associated with protection against HIV‐1 in serodiscordant couples in Burkina Faso

LALLOGO

Djigma

Sorgho³

et al. 2022

Journal of Medical Virology

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The human immunodeficiency virus (HIV) belongs to the Retroviridae family and remains a public health problem in sub-Saharan Africa. Recent reports from WHO have shown that 33 million people died from HIV infections. HIV is one of the most serious fatal human diseases of the 20th and 21st centuries. However, variations in genetic and immunological factors are associated with protection against HIV infection in uninfected people exposed to HIV. This is the case with naturals killers which play an important role in the progression or regression of HIV infection. The objective of this study is to characterize certain HLA (human leukocyte antigen) class II genes and KIR genes in HIV-1 serodiscordant couples in Burkina Faso. This study was carried out at Burkina Faso among nineteen (19) HIV-1 serodiscordant couples.Classical multiplex PCR (SSP-PCR) was used to characterize the presence or absence of the KIR genes and certain class II HLAs (DRB1*11 and DRB1*12). The characterization of the KIR and HLA genes DRB1*11, DRB1*12 in this study demonstrated that the inhibitor KIR2DL5B, would confer protection against HIV-1 infection in seronegative partners (odd ratio [OR] = 0.13 [0.02−0.72] and p = 0.029), and the HLA DRB1*12 allele was associated with protection against HIV-1 infection in seronegative partners (OR = 0.16 [0.03−0.77] and p = 0.038). AA and Bx haplotypes were not found to be associated with HIV-1 infection in serodiscordant couples. This study confirms the involvement of the KIR genes in viral pathologies such as HIV-1 infection. Future larger-scale studies may provide a better understanding of the molecular mechanism by which the KIR haplotype and combination of KIR/HLA are associated with protection against HIV infection.

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“…In addition, the average age of primiparity was very close to 24.04 years and the average number of children per woman was 2.39 children. These trends of late primiparity and low parity could partly explain the increase in breast cancer incidence in Burkina Faso ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Screening of BRCA1 (c.5177_5180delGAAA rs80357867 and c.4986+6T>C rs80358086) and the BRCA2 (c.6445_6446delAT rs80359592) genes for breast cancer prevention in Burkina Faso

Kiendrebeogo¹,

Zoure

Zongo³

et al. 2022

Ethiop J Health Sci

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BACKGROUND: The objective of this study is to search for mutations in the BRCA1 (c.5177_5180delGAAA and c.4986+6T>C) and BRCA2 genes (c.6445_6446delAT) in a population of women diagnosed with breast cancer.METHODS: This is a case-control study that involved 140 participants, including 70 patients with histologically diagnosed breast cancer and 70 healthy women without breast cancer. Mutations in the BRCA1 (rs80357867, rs80358086) and BRCA2 (rs80359592) genes were tested by real-time PCR. The 95% confidence interval Odds Ratio (OR) was used to estimate the associations between specific genotypes and breast cancer.RESULTS: The study revealed that no mutations were detected for rs80359592. Similarly, no reference allele (TTTC/TTTC) of rs80357867 was found in this study. However, the homozygous double mutant (-/) genotype of this rs80357867 was observed in 11.43% and 1.43% of patients and controls respectively, while 88.57% of patients and 98.57% of controls had a heterozygous deletion (TTTC/-). Concerning rs80358086, 8.57% of the patients had a heterozygous mutation (A/G) with no significantly risk association with occurrence of breast cancer (OR = 6.46; 95% CI: 0.75-55.21; p = 0.11). In addition, this heterozygous mutation was significantly associated with a family history of breast cancer (OR=128; 95% CI: 9.46-1730.93) and breast cancer risk in nonmultiparous women (OR=6; 95% CI: 1-35.90; p= 0.05) but no association with overweight/obesity (OR=1.66; 95% CI: 0.18-15.35; p=1).CONCLUSION: This study shows high frequencies of heterozygous mutation of rs80357867 and rs80358086 from patients. In Burkina Faso, these results could help with early diagnosis of breast cancer in patients.

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Carriage of HLA-DRB111 and 112 alleles and risk factors in patients with breast cancer in Burkina Faso

Cited by 6 publications

References 46 publications

HLA class II polymorphisms as prognostic biomarkers for right and left-sided colon cancer

HLA class II polymorphisms as prognostic biomarkers for right and left-sided colon cancer

KIR2DL5B and HLA DRB1*12 alleles seems to be associated with protection against HIV‐1 in serodiscordant couples in Burkina Faso

Screening of BRCA1 (c.5177_5180delGAAA rs80357867 and c.4986+6T>C rs80358086) and the BRCA2 (c.6445_6446delAT rs80359592) genes for breast cancer prevention in Burkina Faso

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