Carpal Tunnel Syndrome with Paracoccidioidomycosis

Paracoccidioidomycosis: epidemiological, clinical, diagnostic and treatment up-dating

“…Equally atypical, but not anecdotal, is the report of carpal tunnel syndrome due to PCM. 46 The authors report a male patient with a history of serologically negative rheumatoid arthritis, in treatment with methotrexate, chloroquine and sporadic intra-articular corticoid infiltrations that evolved to tenosynovitis and carpal tunnel syndrome. Investigation revealed important demyelination of the median nerve and partial denervation of the abductor pollicis brevis muscle, consistent with carpal tunnel syndrome associated to tenosynovitis and specific paracoccidioidomycosis osteoarthritis, besides lung PCM.…”

“…Investigation revealed important demyelination of the median nerve and partial denervation of the abductor pollicis brevis muscle, consistent with carpal tunnel syndrome associated to tenosynovitis and specific paracoccidioidomycosis osteoarthritis, besides lung PCM. 46 Treatment involved surgery and combination of sulfamethoxazole plus trimethoprim, with complete cure.…”

Pulmonary paracoccidioidomycosis: a case report of reactivation in a patient receiving biological therapy

“…The association between PCM and the use of immunosuppressive drugs has already been described in the literature, but until now, there have been no reports on disease reactivation after infliximab administration. Most of the 11 cases previously described were in men aged older than 40 years with pulmonary involvement (Table 1) 4,[8][9][10] .…”

“…Despite the few reports describing the association between biological therapy and reactivation of PCM, none of them described a correlation between the use of infliximab to reactivation of the disease 4,[8][9][10] . Thus, this report presents a case of pulmonary PCM reactivation in a patient receiving infliximab therapy.…”