Carpal Tunnel Syndrome Due to Hydroxyapatite Crystal Deposition Disease

Suresh, S. S.; Raniga, Sameer; Shanmugam, Vijay; George, Mina; Zaki, Hosam

doi:10.1007/s12593-012-0076-9

Cited by 4 publications

(5 citation statements)

References 16 publications

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“…To our best knowledge, this is the first report describing a case of HADD-associated carpal tunnel syndrome with intraosseous invasion of HA depots at the wrist. Carpal tunnel syndrome is either caused by a volume increase of its content or by a decrease of the tunnel volume itself [ 15 ]. In rare cases, crystal deposition diseases like calcium pyrophosphate deposition disease (CPPD), gout and HADD may become space-occupying in the carpal tunnel, particularly when liquified crystals leak from the tendon into peritendinous soft tissues causing flexor tenosynovitis [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Carpal tunnel syndrome is either caused by a volume increase of its content or by a decrease of the tunnel volume itself [ 15 ]. In rare cases, crystal deposition diseases like calcium pyrophosphate deposition disease (CPPD), gout and HADD may become space-occupying in the carpal tunnel, particularly when liquified crystals leak from the tendon into peritendinous soft tissues causing flexor tenosynovitis [ 15 , 16 ]. In the acute inflammatory phase, the median nerve is compressed with sensory symptoms being triggered [ 7 , 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

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Hydroxyapatite deposition disease of the wrist with intraosseous migration to the lunate bone

et al. 2021

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Hydroxyapatite deposition disease (HADD) is a mostly uniarticular, self-limiting condition caused by deposition of hydroxyapatite (HA) crystals in tendons or in the peritendinous soft tissues. Commonly, the glenohumeral joint is affected. More rarely, the HA depot can be cause of a carpal tunnel syndrome due to an acute inflammatory reaction and space-occupying soft tissue oedema. We report a case of acute HA depot located at the volar site of the right wrist with affection of the deep flexor tendons and intraosseous migration into the lunate bone in a 50-year-old female. There are two main goals of this case report: First, to remind the diagnosis of HADD as a cause of wrist pain and also of carpal tunnel syndrome, as this entity being often misdiagnosed clinically, and second, to report a rare case of intraosseous migration of HA crystals into the lunate bone.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hydroxyapatite deposition disease of the wrist with intraosseous migration to the lunate bone

et al. 2021

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Section: Introductionmentioning

confidence: 99%

“…Hydroxyapatite (HA), as an inorganic mineral, is the main component of natural bone inorganic salts, and an indispensable inorganic component of the human skeleton ( 4 ). Research demonstrates that 50% of the human skeleton is comprised of homogeneous inorganic HA ( 4 ). The physicochemical properties, chemical composition and crystal structure of HA are very similar to human bone and are highly safe for humans.…”

Section: Introductionmentioning

confidence: 99%

Osteogenic ability using porous hydroxyapatite scaffold‑based delivery of human placenta‑derived mesenchymal stem cells

et al. 2021

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Previous preliminary studies have suggested that hydroxyapatite with a grooved structure (HAG) scaffold has good osteogenic potential. This type of scaffold may aid osteogenesis during the repair of large maxillofacial bony defects. The ectopic osteogenic effect and underlying mechanism were further studied using porous HAG scaffold-based delivery of human placenta-derived mesenchymal stem cells (hPMSCs). A total of 18 dogs were randomly allocated into a HAG scaffold group and a HAG scaffold-based hPMSC (HAG/hPMSC) group, and three scaffolds were implanted into the dorsal muscle of each dog. Samples were taken for subsequent analysis and tested 4, 8 and 12 weeks following heterotopic implantation. H&E staining was used to study the osteogenic effect in dog dorsal muscles, and RNA sequencing (RNA-seq) was used for exploring the underlying osteogenic mechanism. The osteogenic ability and effector of the HAG/hPMSC group were significantly greater than those of the HAG scaffold group at 4 weeks after implantation. After 12 weeks, a mature bone plate structure was seen in the HAG/hPMSC group. RNA-seq demonstrated that various osteogenesis-related pathways participated at different stages of metabolism, and that the expression of collagen-1 and runt-related transcription factor 2 increased with implantation time. The present study preliminarily focused on the ectopic osteogenic effect of the porous HAG scaffold-based delivery of hPMSCs in vivo , which may be helpful for the improved application of HAG scaffolds in the future.

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“… 1 , 2 , 3 , 4 Acute deposition of hydroxyapatite crystals has also been implicated in acute CTS, along with tumoral calcium pyrophosphate dihydrate (CPPD) causing compression of the median and ulnar nerves. 5 , 6 , 7 Here, we present an uncommon case of new onset of pseudogout, presenting in the hand as both acute carpal tunnel syndrome and acute Guyon canal syndrome. The patient provided written informed consent for the use of deidentified health information and images for research and educational purposes.…”

mentioning

confidence: 96%

Pseudogout: A Rare Cause of Acute Carpal Tunnel Syndrome and Acute Guyon Canal Syndrome

Rackard

Lujan-Hernandez

Vanguri

et al. 2022

Journal of Hand Surgery Global Online

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Carpal Tunnel Syndrome Due to Hydroxyapatite Crystal Deposition Disease

Cited by 4 publications

References 16 publications

Hydroxyapatite deposition disease of the wrist with intraosseous migration to the lunate bone

Hydroxyapatite deposition disease of the wrist with intraosseous migration to the lunate bone

Osteogenic ability using porous hydroxyapatite scaffold‑based delivery of human placenta‑derived mesenchymal stem cells

Pseudogout: A Rare Cause of Acute Carpal Tunnel Syndrome and Acute Guyon Canal Syndrome

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