Carotid artery intimal-medial thickness distribution in general populations as evaluated by B-mode ultrasound. ARIC Investigators.

Howard, George; Sharrett, A. Richey; Heiss, Gerardo; Evans, G W; Chambless, Lloyd E.; Riley, Ward A.; Burke, Gregory L.

doi:10.1161/01.str.24.9.1297

Cited by 646 publications

(484 citation statements)

References 30 publications

Supporting

Mentioning

398

Contrasting

Unclassified

Order By: Relevance

“…This is supported by a low rate of current smoking, a mean SCORE risk of 3.6%, and a high proportion of diagnosed and treated hypertension at study inclusion. Furthermore, the low prevalence of high‐grade stenosis in our study corresponds with previous studies,4, 15, 16, 27 suggesting a similar rather than a greater atherosclerotic burden. Despite this, our results showed the presence of plaque in 9 of 10 participants.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Prevalence of Carotid Plaque in a 63‐ to 65‐Year‐Old Norwegian Cohort From the General Population: The ACE (Akershus Cardiac Examination) 1950 Study

Ihle‐Hansen

Vigen

Rønning

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundNew data on extracranial carotid atherosclerosis are needed, as improved ultrasound techniques may detect more atherosclerosis, the definition of plaque has changed over the years, and better cardiovascular risk control in the population may have changed patterns of carotid arterial wall disease and actual prevalence of established cardiovascular disease. We investigated the prevalence of atherosclerotic carotid plaques and carotid intima–media thickness (cIMT) and their relation to cardiovascular risk factors in a middle‐aged cohort from the general population.Methods and ResultsWe performed carotid ultrasound in 3683 participants who were born in 1950 and included in a population‐based Norwegian study. Carotid plaque and cIMT were assessed according to the Mannheim Carotid Intima–Media Thickness and Plaque Consensus, and a carotid plaque score was used to calculate atherosclerotic burden. The participants were aged 63 to 65 years, and 49% were women. The prevalence of established cardiovascular disease was low (10%), but 62% had hypertension, 53% had hypercholesterolemia, 11% had diabetes mellitus, and 23% were obese. Mean cIMT was 0.73±0.11 mm, and atherosclerotic carotid plaques were present in 87% of the participants (median plaque score: 2; interquartile range: 3). Most of the cardiovascular risk factors, with the exception of diabetes mellitus, obesity and waist–hip ratio, were independently associated with the plaque score. In contrast, only sex, hypertension, obesity, current smoking, and cerebrovascular disease were associated with cIMT.ConclusionsWe found very high prevalence of carotid plaque in this middle‐aged population, and our data support a greater association between cardiovascular risk factors and plaque burden, compared with cIMT.Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT01555411.

show abstract

Section: Discussionsupporting

confidence: 91%

“…Plaque burden increases with age 15, 16, 17. In previous studies, the prevalence of carotid plaques has varied significantly,3, 18, 19, 20, 21, 22, 23, 24 ranging from 25% to 93%.…”

Section: Discussionmentioning

confidence: 93%

Prevalence of Carotid Plaque in a 63‐ to 65‐Year‐Old Norwegian Cohort From the General Population: The ACE (Akershus Cardiac Examination) 1950 Study

Ihle‐Hansen

Vigen

Rønning

et al. 2018

JAHA

View full text Add to dashboard Cite

show abstract

“…Predicted LV mass was calculated using the formula described by de Simone et al 1 Carotid artery ultrasound Intima-media thickness (IMT) and the lumen diameter of the common carotid arteries were measured by ultrasound using the ACUSON 128XP/10c (Acuson Corporation, CA, USA) and a linear 7 MHz transducer. IMT of the right and left common carotid artery was measured in the 1 cm segment proximal to the dilation of the carotid bulb as described by Howard et al 13 The longitudinal Bmode image was accepted as valid when a double line representing lumen-intima and media-adventitia interfaces was visualized in the longest possible segment of both near and far walls. At end-diastole, IMT of the far walls of the left as well as of the right common carotid artery were measured at 10 points 1 mm apart using the leading-edge convention, and the mean value was calculated.…”

Section: Echocardiographymentioning

confidence: 99%

Is inappropriate left ventricular mass related to neurohormonal factors and/or arterial changes in hypertension? a LIFE substudy

et al. 2004

View full text Add to dashboard Cite

We investigated whether inappropriately high left ventricular (LV) mass, defined as observed LV mass exceeding the level of individual LV mass predicted from gender, height, and stroke work, may be associated with an imbalance between growth-promoting and growth-inhibitory factors and/or structural vascular changes. In 53 patients with hypertension and electrocardiographic LV hypertrophy, 24-h ambulatory blood pressure (BP); echocardiographic LV mass, stroke volume and stroke work; minimal forearm vascular resistance (MFVR); and intima-media cross-sectional area in common carotid arteries (IMA) were evaluated after 2 weeks of placebo treatment. Serum insulin, plasma epinephrine, norepinephrine, endothelin, angiotensin II, aldosterone, and brain natriuretic peptide (BNP) were also measured. High observed LV mass was related to high IMA (r ¼ 0.46, Po0.001), MFVR (in men: r ¼ 0.36, Po0.05), 24-h ambulatory systolic BP (r ¼ 0.30, P ¼ 0.06), and lower plasma angiotensin II (r ¼ À0.33, Po0.05), but not to other circulating growth factors. Stroke work was similarly related to IMA (r ¼ 0.42, Po0.01), MFVR (in men: r ¼ 0.41, Po0.05), and plasma angiotensin II (r ¼ À0.32, Po0.05). Inappropriate LV mass, identified by the ratio between observed LV mass and the value predicted for gender, height, and stroke work, was not significantly related to any of the arterial or neurohormonal variables. In this small series of older hypertensive patients, inappropriate LV mass was not significantly related to arterial changes or to measured circulating growth factors, although weak relations cannot be excluded. Alternatively, inappropriately high LV mass might be related to unmeasured factors such as local myocardial alterations in growth factors and/or genetic predisposition to develop excessive LV hypertrophy.

show abstract

“…8 CAIMT was measured bilaterally by ultrasonography at three locations in the common and internal carotid arteries. 9 Cross-sectional data on total daily sodium intake, excluding that from salt added during preparation or eating, was estimated from responses to the EPIC food frequency questionnaire. 10 Additional questions on the frequency (always, usually, sometimes, rarely, never) of addition of salt during preparation and at the table and the use of medications were also asked.…”

mentioning

confidence: 99%

The relation between diarrhoeal episodes in infancy and both blood pressure and sodium intake in later life: The Newcastle Thousand Families Study

et al. 2008

View full text Add to dashboard Cite

Carotid artery intimal-medial thickness distribution in general populations as evaluated by B-mode ultrasound. ARIC Investigators.

Abstract: Background and Purpose: B-mode ultrasound is a widely used technique for the clinical and epidemio-

Cited by 646 publications

References 30 publications

Prevalence of Carotid Plaque in a 63‐ to 65‐Year‐Old Norwegian Cohort From the General Population: The ACE (Akershus Cardiac Examination) 1950 Study

Prevalence of Carotid Plaque in a 63‐ to 65‐Year‐Old Norwegian Cohort From the General Population: The ACE (Akershus Cardiac Examination) 1950 Study

Is inappropriate left ventricular mass related to neurohormonal factors and/or arterial changes in hypertension? a LIFE substudy

The relation between diarrhoeal episodes in infancy and both blood pressure and sodium intake in later life: The Newcastle Thousand Families Study

Contact Info

Product

Resources

About