Carotid-Artery Intima and Media Thickness as a Risk Factor for Myocardial Infarction and Stroke in Older Adults

O’Leary, Daniel H.; Polak, Joseph F.; Kronmal, Richard A.; Manolio, Teri A.; Burke, Gregory L.; Wolfson, Sidney K.

doi:10.1056/nejm199901073400103

Cited by 4,253 publications

(3,065 citation statements)

References 38 publications

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“…IMT was defined as the distance from the leading edge of the first echogenic line to that of the second as previously described. 12 The first line represents the lumen-intima interface, and the second line represents the collagen-containing upper layer of the adventitia. The carotid artery was scanned bilaterally in longitudinal and transverse planes.…”

Section: Measurement Of Carotid Imtmentioning

confidence: 99%

“…13,14 Mean-IMT was measured at the site of max-IMT and at two other points, 1 cm upstream and 1 cm downstream from this site, and these determinations were averaged. 12,14 All measurements were performed by a single expert sonographer who was blinded to the patient's clinical details. The reproducibility of the IMT was evaluated by taking two measurements 2 weeks apart on six volunteers, obtaining an intraclass correlation of 0.98.…”

Section: Measurement Of Carotid Imtmentioning

confidence: 99%

“…An increase in carotid arterial intima-media thickness (IMT) is an established marker of early atherosclerosis and is predictive of future cardiovascular and stroke events. 11,12 In the present study, we investigated the association between circulating omentin levels and carotid IMT in apparently healthy Japanese males.…”

Section: Introductionmentioning

confidence: 99%

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Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

et al. 2011

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Obesity is causally linked with the development of atherosclerosis. Omentin is an adipocytokine whose concentrations are reduced in obese individuals. Here we examined the relationship between plasma omentin levels and carotid intima-media thickness (IMT), a marker of early atherosclerosis, in apparently healthy Japanese men. Participants were 100 Japanese men who underwent a medical checkup. Maximal IMT (max-IMT) and mean-IMT in common carotid artery were measured by highresolution carotid ultrasound system. Plasma omentin concentrations were determined by enzyme-linked immunosorbent assay. Circulating omentin levels correlated negatively with body mass index, waist circumference, fasting glucose, creatinine, max-IMT and mean-IMT, and positively with estimated glomerular filtration rates (eGFR). Single regression analysis demonstrated that max-IMT associated with age, eGFR and omentin levels, and that mean-IMT associated with age, fasting glucose, eGFR and omentin levels. Multiple regression analysis revealed that omentin levels, together with age, correlated with max-IMT and mean-IMT. Our data document that circulating omentin levels independently and negatively associate with carotid IMT in this population, suggesting that measurement of omentin may be useful for assessment of carotid IMT.

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Section: Measurement Of Carotid Imtmentioning

confidence: 99%

Section: Measurement Of Carotid Imtmentioning

confidence: 99%

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Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

et al. 2011

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“…14 High-resolution ultrasound has been used for many years to assess carotid artery intima-media thickness (IMT) in adults. 15 Carotid IMT is associated with coronary atherosclerosis and future risk of stroke and myocardial infarction, 16 and provides a noninvasively obtainable measure of the total atherosclerotic burden.…”

Section: Early Atherosclerosismentioning

confidence: 99%

Endothelial dysfunction and arterial abnormalities in childhood obesity

Skilton

Celermajer

2006

Int J Obes

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“…Noninvasive ultrasonographic assessment of carotid intima‐media thickness and total plaque area are associated with future risk of ischemic stroke and myocardial infarction 8, 9. However, ultrasound provides limited information regarding morphological plaque characteristics indicative of plaque vulnerability (ie, presence of a large lipid‐rich necrotic core, a thin inflamed fibrous cap, and intraplaque hemorrhage) 10, 11.…”

Section: Introductionmentioning

confidence: 99%

Negative Carotid Artery Remodeling in Early Type 2 Diabetes Mellitus and Increased Carotid Plaque Vulnerability in Obesity as Assessed by Magnetic Resonance Imaging

Laugesen

Høyem

Thrysøe

et al. 2018

JAHA

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BackgroundIschemic stroke from carotid plaque embolism remains a major cause of morbidity in patients with type 2 diabetes mellitus (T2DM). However, the effect of early T2DM and obesity on carotid remodeling and plaque burden remains elusive. We assessed carotid remodeling and plaque composition by carotid magnetic resonance imaging in patients with short‐duration T2DM compared with a sex‐ and age‐matched control group.Methods and ResultsOne hundred patients with T2DM (duration <5 years) and 100 sex‐ and age‐matched controls underwent bilateral carotid artery magnetic resonance imaging in a 1.5‐T magnetic resonance imaging scanner. Plaque burden was quantified by normalized wall index, maximum wall thickness, maximum wall area, and minimum lumen size. Plaque morphology was quantified by calcified plaque volume, necrotic core volume, and loose matrix volume. Magnetic resonance imaging data were available for 149 and 177 carotid arteries from T2DM patients and controls, respectively. Adjusted for age and sex, T2DM was associated with increased plaque burden indicated by a higher normalized wall index (ratio 1.03 [95% confidence interval, 1.002; 1.06], P=0.03), and negative remodeling indicated by a lower minimum lumen area (ratio 0.81 [0.74; 0.89], P<0.001), and lower maximum wall area (ratio 0.94 [0.88; 1.00], P=0.048) compared with controls. In both T2DM and controls, body mass index ≥30.0 kg/m2 was associated with an 80% increase in total calcified plaque volume, and a 44% increase in necrotic core volume compared with body mass index <25.0 kg/m2.ConclusionsShort‐duration T2DM was associated with increased carotid plaque burden and negative remodeling. Obesity was associated with increased carotid artery necrotic core volume and calcification independently of diabetes mellitus status.Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT00674271.

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Carotid-Artery Intima and Media Thickness as a Risk Factor for Myocardial Infarction and Stroke in Older Adults

Abstract: Increases in the thickness of the intima and media of the carotid artery, as measured noninvasively by ultrasonography, are directly associated with an increased risk of myocardial infarction and stroke in older adults without a history of cardiovascular disease.

Cited by 4,253 publications

References 38 publications

Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

Endothelial dysfunction and arterial abnormalities in childhood obesity

Negative Carotid Artery Remodeling in Early Type 2 Diabetes Mellitus and Increased Carotid Plaque Vulnerability in Obesity as Assessed by Magnetic Resonance Imaging

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