Graham W. Burton, Janusz Daroszewski, James G. Nickerson, James B. Johnston, Trevor J. Mogg, Grigory B. Nikiforov
Abstract: Carotenoids are reported to have immunological effects independent of vitamin A activity. Although antioxidant activity has been suggested as a basis of action, the ability of carotenoids to autoxidize to numerous non-vitamin A products with immunological activity is an alternative yet to be fully explored. We have undertaken a systematic study of β-carotene autoxidation and tested the product mixture for immunological activity. Autoxidation proceeds predominantly by oxygen copolymerization, leading to a defi…
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